Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0064 | 0.3864 | 0.3796 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.1071 | 0.2772 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3594 | 0.3522 |
Brugia malayi | RNA binding protein | 0.0064 | 0.3864 | 0.3796 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.214 | 0.214 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.1071 | 0.2772 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.1071 | 0.1071 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3864 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.1071 | 0.181 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.1071 | 0.181 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0454 | 0.0454 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3864 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 0.1071 | 0.2772 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0454 | 0.1175 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.3864 | 0.3864 |
Onchocerca volvulus | 0.0027 | 0.1071 | 0.5 | |
Schistosoma mansoni | lamin | 0.0027 | 0.1071 | 0.181 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0454 | 0.1175 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0454 | 0.1175 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0454 | 0.0348 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.3864 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.011 | 0.011 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3594 | 0.3594 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0454 | 0.0454 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.1071 | 0.0972 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.1071 | 0.2772 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0454 | 0.0348 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3864 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.3864 | 0.3796 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.3864 | 0.3864 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3594 | 0.3522 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.1071 | 0.1071 |
Onchocerca volvulus | 0.0027 | 0.1071 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.3864 | 0.3864 |
Echinococcus multilocularis | lamin | 0.0027 | 0.1071 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3864 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3864 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.1071 | 0.2772 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0454 | 0.1175 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1033 | 0.1033 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.3864 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.1071 | 0.0972 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.214 | 0.2053 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0454 | 0.1175 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.214 | 0.4945 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0454 | 0.1175 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3594 | 0.3594 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.