Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endothelin converting enzyme 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.7992 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.3858 | 0.3858 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4134 | 0.4134 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0128 | 1 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0128 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0128 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0128 | 1 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.0128 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0128 | 1 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.3858 | 0.3858 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.7992 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3858 | 0.3858 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3858 | 0.3858 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4134 | 0.4134 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3858 | 0.3858 |
Entamoeba histolytica | histone deacetylase, putative | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.7992 | 0.7992 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3858 | 0.3858 |
Leishmania major | histone deacetylase, putative | 0.0128 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 3 | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4134 | 0.4134 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0128 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.7992 | 0.7992 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4134 | 0.4134 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0128 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.7992 | 0.7962 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0128 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 1 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0128 | 1 | 1 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0128 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4134 | 0.4134 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4134 | 0.4134 |
Schistosoma mansoni | histone deacetylase | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.7992 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.7992 | 0.7992 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | In vitro inhibition of phosphoramidon-sensitive membrane bound zinc metalloprotease Endothelin-converting enzyme from partially purified guinea pig lungs | ChEMBL. | No reference |
IC50 (binding) | > 10000 nM | In vitro inhibition of phosphoramidon-sensitive membrane bound zinc metalloprotease Endothelin-converting enzyme from partially purified guinea pig lungs | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.