Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | carbonic anhydrase, putative | 0.1078 | 0.7322 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0856 | 0.5725 | 0.7819 |
Schistosoma mansoni | hypothetical protein | 0.0318 | 0.1859 | 0.2539 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0084 | 0.018 | 0.0239 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0045 | 0.0061 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0045 | 0.0061 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.074 | 0.4892 | 0.5187 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0318 | 0.1859 | 0.2539 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0856 | 0.5725 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0318 | 0.1859 | 0.3193 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0622 | 0.4043 | 0.7062 |
Trichomonas vaginalis | conserved hypothetical protein | 0.145 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0318 | 0.1859 | 0.3193 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0084 | 0.018 | 0.0239 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0318 | 0.1859 | 0.3193 |
Echinococcus multilocularis | tumor protein p63 | 0.0404 | 0.2477 | 0.4282 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0719 | 0.474 | 0.8266 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0719 | 0.474 | 0.8266 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0206 | 0.1059 | 0.1786 |
Plasmodium falciparum | carbonic anhydrase | 0.0318 | 0.1859 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0318 | 0.1859 | 0.2539 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0318 | 0.1859 | 0.3193 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0141 | 0.059 | 0.0959 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0318 | 0.1859 | 0.3247 |
Echinococcus granulosus | tumor protein p63 | 0.0404 | 0.2477 | 0.4282 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0856 | 0.5725 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0856 | 0.5725 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0045 | 0.0061 |
Echinococcus multilocularis | carbonic anhydrase | 0.0318 | 0.1859 | 0.3193 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0065 | 0.0045 | 0.0078 |
Schistosoma mansoni | carbonic anhydrase | 0.1078 | 0.7322 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.145 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0856 | 0.5725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.059 | 0.103 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0856 | 0.5725 | 0.7819 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0856 | 0.5725 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0206 | 0.1059 | 0.1786 |
Echinococcus multilocularis | carbonic anhydrase | 0.0318 | 0.1859 | 0.3193 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0856 | 0.5725 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0318 | 0.1859 | 0.2539 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.1859 | 0.3247 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1078 | 0.7322 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0045 | 0.0061 |
Echinococcus granulosus | carbonic anhydrase | 0.0318 | 0.1859 | 0.3193 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.1859 | 0.3247 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0045 | 0.0078 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0318 | 0.1859 | 0.3193 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0622 | 0.4043 | 0.7062 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.1859 | 0.3247 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1112 | 0.757 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0318 | 0.1859 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0719 | 0.474 | 0.6474 |
Schistosoma mansoni | carbonic anhydrase | 0.0318 | 0.1859 | 0.2539 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0856 | 0.5725 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0318 | 0.1859 | 0.3193 |
Echinococcus granulosus | carbonic anhydrase II | 0.0856 | 0.5725 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1078 | 0.7322 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0622 | 0.4043 | 0.7039 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0856 | 0.5725 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1059 | 0.185 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0206 | 0.1059 | 0.185 |
Echinococcus multilocularis | carbonic anhydrase | 0.0318 | 0.1859 | 0.3193 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0318 | 0.1859 | 0.3193 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.059 | 0.0805 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -3.91 % | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei strain 90-13 assessed as inhibition of parasite growth at 10 ug/ml after 72 hrs by resazurin reduction test | ChEMBL. | 24530491 |
Inhibition (functional) | = 35.82 % | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei strain 90-13 assessed as inhibition of parasite growth at 1 ug/ml after 72 hrs by resazurin reduction test | ChEMBL. | 24530491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.