Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0188 | 0.1919 | 0.2759 |
Echinococcus granulosus | FTZ F1 alpha | 0.0398 | 0.5242 | 0.7816 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.2275 | 0.0492 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0188 | 0.1919 | 0.0054 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0188 | 0.1919 | 0.353 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0188 | 0.1919 | 0.0054 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0192 | 0.1982 | 0.3652 |
Schistosoma mansoni | nuclear receptor | 0.0188 | 0.1919 | 0.353 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5242 | 0.4144 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0192 | 0.1982 | 1 |
Brugia malayi | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Onchocerca volvulus | 0.0398 | 0.5242 | 0.4967 | |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | nuclear receptor RXR | 0.0188 | 0.1919 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.2275 | 0.0492 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.2275 | 0.0492 |
Schistosoma mansoni | zinc finger protein | 0.0188 | 0.1919 | 0.353 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0398 | 0.5242 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0188 | 0.1919 | 0.0054 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0398 | 0.5242 | 0.7816 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0398 | 0.5242 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0398 | 0.5242 | 0.7816 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.021 | 0.2275 | 0.0492 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0398 | 0.5242 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0398 | 0.5242 | 0.4144 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0398 | 0.5242 | 0.7816 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | tailless protein | 0.0188 | 0.1919 | 0.0054 |
Schistosoma mansoni | coup transcription factor | 0.0398 | 0.5242 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0398 | 0.5242 | 0.7816 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0073 | 0.0106 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0073 | 0.0106 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0401 | 0.5287 | 0.4198 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.2319 | 0.0546 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.2479 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0398 | 0.5242 | 0.4144 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0398 | 0.5242 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0398 | 0.5242 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0188 | 0.1919 | 0.2759 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0398 | 0.5242 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0398 | 0.5242 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0139 | 0.1145 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0188 | 0.1919 | 0.0054 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0398 | 0.5242 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0119 | 0.0828 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0398 | 0.5242 | 0.4144 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0398 | 0.5242 | 0.4967 |
Brugia malayi | hypothetical protein | 0.021 | 0.2275 | 0.0492 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | nuclear receptor NHR-67 | 0.0188 | 0.1919 | 0.0054 |
Brugia malayi | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0398 | 0.5242 | 0.4144 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.021 | 0.2275 | 0.4223 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0073 | 0.0106 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Brugia malayi | hypothetical protein | 0.021 | 0.2275 | 0.0492 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0398 | 0.5242 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0188 | 0.1919 | 0.0054 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | DR-78 | 0.0188 | 0.1919 | 0.0054 |
Schistosoma mansoni | thyroid hormone receptor | 0.0398 | 0.5242 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Schistosoma mansoni | nuclear receptor | 0.0188 | 0.1919 | 0.353 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0398 | 0.5242 | 0.7816 |
Loa Loa (eye worm) | steroid hormone receptor | 0.07 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0188 | 0.1919 | 0.353 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0192 | 0.1982 | 0.2855 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0192 | 0.1982 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0489 | 0.6677 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0188 | 0.1919 | 0.353 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0188 | 0.1919 | 0.0054 |
Brugia malayi | nuclear receptor NHR-88 | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.021 | 0.2275 | 0.0492 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0398 | 0.5242 | 0.7816 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0398 | 0.5242 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0398 | 0.5242 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.021 | 0.2275 | 0.3301 |
Schistosoma mansoni | thyroid hormone receptor | 0.0398 | 0.5242 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0188 | 0.1919 | 0.353 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0398 | 0.5242 | 0.4144 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0188 | 0.1919 | 0.2759 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0188 | 0.1919 | 0.2759 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0398 | 0.5242 | 0.4144 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0139 | 0.1145 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0398 | 0.5242 | 0.4144 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0398 | 0.5242 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0398 | 0.5242 | 0.7816 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.5242 | 0.4144 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0073 | 0.0106 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0398 | 0.5242 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0188 | 0.1919 | 0.2759 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.021 | 0.2275 | 0.4223 |
Brugia malayi | nuclear hormone receptor | 0.0398 | 0.5242 | 0.4144 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0612 | 0.861 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0188 | 0.1919 | 0.353 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0192 | 0.1982 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0188 | 0.1919 | 0.353 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0188 | 0.1919 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1919 | 0.0054 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0398 | 0.5242 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0398 | 0.5242 | 0.4144 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.021 | 0.2275 | 0.4223 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0398 | 0.5242 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0073 | 0.0106 | 0.5 |
Brugia malayi | conserved hypotetical protein | 0.0188 | 0.1919 | 0.0054 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0188 | 0.1919 | 0.353 |
Brugia malayi | nuclear receptor RXR | 0.021 | 0.2275 | 0.0492 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.021 | 0.2275 | 0.0492 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0188 | 0.1919 | 0.353 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0398 | 0.5242 | 0.4144 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | ecdysone receptor | 0.0188 | 0.1919 | 0.0054 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0398 | 0.5242 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0192 | 0.1982 | 0.3652 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0188 | 0.1919 | 0.353 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0398 | 0.5242 | 0.4144 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0398 | 0.5242 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0398 | 0.5242 | 0.7816 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0188 | 0.1919 | 0.353 |
Brugia malayi | nuclear hormone receptor | 0.0401 | 0.5287 | 0.4198 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0188 | 0.1919 | 0.0054 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0398 | 0.5242 | 0.4144 |
Schistosoma mansoni | nuclear hormone receptor | 0.0188 | 0.1919 | 0.353 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0398 | 0.5242 | 0.4144 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0398 | 0.5242 | 0.4967 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.2275 | 0.0492 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0398 | 0.5242 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0398 | 0.5242 | 0.4144 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0188 | 0.1919 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.2275 | 0.0492 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0073 | 0.0106 | 0.5 |
Chlamydia trachomatis | biotin carboxylase | 0.0066 | 0 | 0.5 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0192 | 0.1982 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0398 | 0.5242 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.