TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.529 | Formula: C18H32O5Si
H donors: 0 H acceptors: 0 LogP: 4.48 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: C[C@H]1[C@H](O[C@H]2[C@@]34[C@H]1CC[C@H]([C@@H]4CC[C@](O2)(OO3)C)C)O[Si](C)(C)C
InChi: 1S/C18H32O5Si/c1-11-7-8-14-12(2)15(21-24(4,5)6)19-16-18(14)13(11)9-10-17(3,20-16)22-23-18/h11-16H,7-10H2,1-6H3/t11-,12-,13+,14+,15-,16-,17-,18-/m1/s1
InChiKey: JUFSDODNZWADPX-VMAIWCPRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.00483598	0.0518694	0.0518694
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0148042	0.300864	0.300864
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.00483598	0.0518694	0.0672618
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Loa Loa (eye worm)	hypothetical protein	0.00601515	0.0813237	0.106283
Loa Loa (eye worm)	hypothetical protein	0.00409786	0.0334319	0.0368784
Trypanosoma cruzi	Aminopeptidase M1, putative	0.00339613	0.0159036	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0030791	0.00798432	0.00798432
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.00409786	0.0334319	0.0368784
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Loa Loa (eye worm)	aminopeptidase N	0.00339613	0.0159036	0.0114765
Loa Loa (eye worm)	hypothetical protein	0.0148042	0.300864	0.424438
Trypanosoma brucei	Aminopeptidase M1, putative	0.00339613	0.0159036	0.5
Loa Loa (eye worm)	peptidase family M13 containing protein	0.00585131	0.0772311	0.100352
Schistosoma mansoni	memapsin-2 (A01 family)	0.0427933	1	1
Loa Loa (eye worm)	hypothetical protein	0.00409786	0.0334319	0.0368784
Schistosoma mansoni	opsin-like receptor	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	nAChR subunit	0.00350879	0.0187176	0.0187176
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.00339613	0.0159036	0.0121377
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0030791	0.00798432	0.00798432
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.00760665	0.121078	0.163894
Brugia malayi	Peptidase family M13 containing protein	0.00731296	0.113741	0.153262
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0152841	0.312851	0.441811
Echinococcus multilocularis	endothelin converting enzyme 1	0.00731296	0.113741	0.162092
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.00760665	0.121078	0.173336
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0080822	0.132956	0.181108
Onchocerca volvulus		0.00350879	0.0187176	0.0164508
Brugia malayi	Cation transporter family protein	0.0148042	0.300864	0.424438
Loa Loa (eye worm)	hypothetical protein	0.00525941	0.0624462	0.0789256
Onchocerca volvulus		0.00760665	0.121078	0.173336
Echinococcus granulosus	glycine receptor subunit alpha 1	0.00760665	0.121078	0.173336
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.00339613	0.0159036	0.0121377
Schistosoma mansoni	neurotransmitter gated ion channel	0.00350879	0.0187176	0.0187176
Echinococcus granulosus	glycine receptor subunit alpha 1	0.00760665	0.121078	0.173336
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.00760665	0.121078	0.163894
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.00339613	0.0159036	0.5
Loa Loa (eye worm)	hypothetical protein	0.00585131	0.0772311	0.100352
Schistosoma mansoni	neurotransmitter gated ion channel	0.00409786	0.0334319	0.0334319
Loa Loa (eye worm)	peptidase family M13 containing protein	0.00585131	0.0772311	0.100352
Brugia malayi	hypothetical protein	0.00339613	0.0159036	0.0114765
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.00760665	0.121078	0.173336
Loa Loa (eye worm)	peptidase family M1 containing protein	0.00926255	0.16244	0.223836
Schistosoma mansoni	neuropeptide receptor	0.0030791	0.00798432	0.00798432
Onchocerca volvulus		0.00525941	0.0624462	0.0834727
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	neurotransmitter gated ion channel	0.00350879	0.0187176	0.0187176
Schistosoma mansoni	protein kinase	0.0051696	0.0602029	0.0602029
Brugia malayi	Peptidase family M1 containing protein	0.00339613	0.0159036	0.0114765
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0291992	0.660436	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	nAChR subunit	0.00760665	0.121078	0.121078
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.00760665	0.121078	0.173336
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.00339613	0.0159036	0.0121377
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.030704	0.698025	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.00339613	0.0159036	0.0121377
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.00760665	0.121078	0.163894
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.00339613	0.0159036	0.0121377
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Loa Loa (eye worm)	hypothetical protein	0.0148042	0.300864	0.424438
Loa Loa (eye worm)	hypothetical protein	0.00601515	0.0813237	0.106283
Loa Loa (eye worm)	hypothetical protein	0.00806851	0.132614	0.180613
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0051696	0.0602029	0.0756747
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0291992	0.660436	1
Loa Loa (eye worm)	hypothetical protein	0.00731296	0.113741	0.153262
Loa Loa (eye worm)	hypothetical protein	0.00601515	0.0813237	0.106283
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.00760665	0.121078	0.163894
Echinococcus multilocularis	inhibitor of apoptosis protein	0.00525941	0.0624462	0.0834727
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.00483598	0.0518694	0.0672618
Schistosoma mansoni	apoptosis regulator bax	0.0080822	0.132956	0.132956
Loa Loa (eye worm)	hypothetical protein	0.00731296	0.113741	0.153262
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0030791	0.00798432	0.00798432
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.00409786	0.0334319	0.0368784
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.00760665	0.121078	0.163894
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.00339613	0.0159036	0.0159036
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.00760665	0.121078	0.173336
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.00760665	0.121078	0.121078
Onchocerca volvulus		0.00350879	0.0187176	0.0164508
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	hypothetical protein	0.00601515	0.0813237	0.106283
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	nAChR subunit	0.00760665	0.121078	0.121078
Loa Loa (eye worm)	hypothetical protein	0.0112954	0.213218	0.297423
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.00760665	0.121078	0.173336
Schistosoma mansoni	neuropeptide f receptor 76f	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Schistosoma mansoni	neuropeptide receptor	0.0030791	0.00798432	0.00798432
Onchocerca volvulus		0.0148042	0.300864	0.448891
Loa Loa (eye worm)	hypothetical protein	0.00409786	0.0334319	0.0368784
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	hypothetical protein	0.0080822	0.132956	0.132956
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Echinococcus granulosus	atrial natriuretic peptide receptor	0.00451318	0.043806	0.0549033
Brugia malayi	Latrophilin receptor protein 2	0.00483598	0.0518694	0.0635978
Loa Loa (eye worm)	apoptosis regulator protein	0.0080822	0.132956	0.181108
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	ACC-1 protein	0.00760665	0.121078	0.163894
Brugia malayi	Cation transporter family protein	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.00350879	0.0187176	0.0155546
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.00339613	0.0159036	0.0121377
Schistosoma mansoni	histamine h1 receptor	0.0030791	0.00798432	0.00798432
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.00525941	0.0624462	0.0834727
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0051696	0.0602029	0.0800344
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.00350879	0.0187176	0.0164508
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0030791	0.00798432	0.00798432
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.00339613	0.0159036	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104481	0.192054	0.266752
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.00483598	0.0518694	0.0672618
Loa Loa (eye worm)	hypothetical protein	0.00409786	0.0334319	0.0368784
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.00339613	0.0159036	0.5
Schistosoma mansoni	hypothetical protein	0.0104481	0.192054	0.192054
Onchocerca volvulus	Deterin homolog	0.00525941	0.0624462	0.0834727
Echinococcus multilocularis	aminopeptidase N	0.0114646	0.217446	0.321038
Schistosoma mansoni	opsin-like receptor	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	hypothetical protein	0.00409786	0.0334319	0.0368784
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.00525941	0.0624462	0.0789256
Loa Loa (eye worm)	hypothetical protein	0.00585131	0.0772311	0.100352
Schistosoma mansoni	acetylcholine receptor subunit beta	0.00350879	0.0187176	0.0187176
Mycobacterium ulcerans	adenylylate/guanylate cyclase	0.00394348	0.0295756	0.139742
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.00760665	0.121078	0.163894
Trypanosoma brucei	Aminopeptidase M1, putative	0.00339613	0.0159036	0.5
Onchocerca volvulus		0.00409786	0.0334319	0.039003
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.00760665	0.121078	0.163894
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.00339613	0.0159036	0.0121377
Schistosoma mansoni	opsin-like receptor	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	nAChR subunit	0.00760665	0.121078	0.121078
Onchocerca volvulus	Putative nachr subunit	0.0291992	0.660436	1
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	nAChR subunit	0.00760665	0.121078	0.121078
Onchocerca volvulus		0.0045535	0.0448134	0.0564472
Schistosoma mansoni	nAChR subunit	0.00760665	0.121078	0.121078
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.00483598	0.0518694	0.0672618
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.00760665	0.121078	0.173336
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.00409786	0.0334319	0.0334319
Echinococcus multilocularis	nAChR subunit	0.00760665	0.121078	0.173336
Schistosoma mansoni	growth hormone secretagogue receptor	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	amine GPCR	0.0030791	0.00798432	0.00798432
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0291992	0.660436	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.00350879	0.0187176	0.0155546
Onchocerca volvulus		0.00409786	0.0334319	0.039003
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Loa Loa (eye worm)	hypothetical protein	0.00409786	0.0334319	0.0368784
Brugia malayi	latrophilin 2 splice variant baaae	0.0104481	0.192054	0.266752
Loa Loa (eye worm)	hypothetical protein	0.0102706	0.187621	0.260327
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Entamoeba histolytica	hypothetical protein	0.00409786	0.0334319	1
Schistosoma mansoni	acetylcholine receptor-related	0.00350879	0.0187176	0.0187176
Trypanosoma cruzi	aminopeptidase, putative	0.00339613	0.0159036	0.5
Brugia malayi	hypothetical protein	0.00350879	0.0187176	0.0155546
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.00760665	0.121078	0.163894
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.00731296	0.113741	0.113741
Schistosoma mansoni	hypothetical protein	0.00483598	0.0518694	0.0518694
Toxoplasma gondii	PAN domain-containing protein	0.0290735	0.657297	1
Echinococcus granulosus	nAChR subunit	0.00409786	0.0334319	0.039003
Schistosoma mansoni	nAChR subunit	0.00350879	0.0187176	0.0187176
Brugia malayi	Peptidase family M1 containing protein	0.0114646	0.217446	0.30355
Schistosoma mansoni	hypothetical protein	0.0030791	0.00798432	0.00798432
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.00760665	0.121078	0.163894
Schistosoma mansoni	hypothetical protein	0.0080822	0.132956	0.132956
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.00350879	0.0187176	0.0155546
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.00760665	0.121078	0.163894
Brugia malayi	Cation transporter family protein	0.00760665	0.121078	0.163894
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0037995	0.0259791	0.0259791
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0080822	0.132956	0.191542
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0080822	0.132956	0.191542
Echinococcus granulosus	GPCR family 2	0.00483598	0.0518694	0.0672618
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.00350879	0.0187176	0.0155546
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.00731296	0.113741	0.153262
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.00760665	0.121078	0.163894
Schistosoma mansoni	biogenic amine receptor	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	hypothetical protein	0.00525941	0.0624462	0.0789256
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	hypothetical protein	0.0080822	0.132956	0.181108
Echinococcus multilocularis	glycine receptor subunit beta	0.00760665	0.121078	0.173336
Schistosoma mansoni	biogenic amine receptor	0.0030791	0.00798432	0.00798432
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.00339613	0.0159036	0.0121377
Echinococcus granulosus	receptor type guanylyl cyclase	0.0051696	0.0602029	0.0800344
Brugia malayi	excitatory GABA receptor EXP-1A	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.00339613	0.0159036	0.5
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.00350879	0.0187176	0.0164508
Loa Loa (eye worm)	acetylcholine receptor protein	0.00350879	0.0187176	0.0155546
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Brugia malayi	hypothetical protein	0.00350879	0.0187176	0.0155546
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.00760665	0.121078	0.173336
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.00760665	0.121078	0.173336
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0030791	0.00798432	0.00798432
Echinococcus granulosus	glycine receptor subunit alpha 1	0.00760665	0.121078	0.173336
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.00451318	0.043806	0.0549033
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0291992	0.660436	0.945527
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	LGC-31 protein	0.00760665	0.121078	0.163894
Loa Loa (eye worm)	hypothetical protein	0.00483598	0.0518694	0.0635978
Schistosoma mansoni	amine GPCR	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	hypothetical protein	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0030791	0.00798432	0.00798432
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.00350879	0.0187176	0.0164508
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0080822	0.132956	0.191542
Schistosoma mansoni	nAChR subunit	0.00760665	0.121078	0.121078
Schistosoma mansoni	neuropeptide receptor	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.00760665	0.121078	0.121078
Schistosoma mansoni	amine GPCR	0.0030791	0.00798432	0.00798432
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.00350879	0.0187176	0.0164508
Loa Loa (eye worm)	ACC-1 protein	0.00760665	0.121078	0.163894
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.00760665	0.121078	0.163894
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.00760665	0.121078	0.121078
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	neuropeptide F-like receptor	0.0030791	0.00798432	0.00798432
Echinococcus granulosus	glycine receptor subunit beta	0.00760665	0.121078	0.173336
Schistosoma mansoni	hypothetical protein	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0030791	0.00798432	0.00798432
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.00731296	0.113741	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0030791	0.00798432	0.00798432
Echinococcus granulosus	inhibitor of apoptosis protein	0.00525941	0.0624462	0.0834727
Loa Loa (eye worm)	hypothetical protein	0.00585131	0.0772311	0.100352
Brugia malayi	hypothetical protein	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.00409786	0.0334319	0.0334319
Loa Loa (eye worm)	hypothetical protein	0.0152841	0.312851	0.441811
Loa Loa (eye worm)	hypothetical protein	0.00601515	0.0813237	0.106283
Echinococcus granulosus	nAChR subunit	0.00760665	0.121078	0.173336
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0291992	0.660436	1
Loa Loa (eye worm)	hypothetical protein	0.00601515	0.0813237	0.106283
Schistosoma mansoni	neuropeptide F-like receptor	0.0030791	0.00798432	0.00798432
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0051696	0.0602029	0.0800344
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.00760665	0.121078	0.163894
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.00525941	0.0624462	0.0834727
Onchocerca volvulus		0.0114646	0.217446	0.321038
Schistosoma mansoni	nAChR subunit	0.00760665	0.121078	0.121078
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0080822	0.132956	0.132956
Schistosoma mansoni	biogenic amine receptor	0.0030791	0.00798432	0.00798432
Onchocerca volvulus		0.00760665	0.121078	0.173336
Echinococcus multilocularis	nAChR subunit	0.00409786	0.0334319	0.039003
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.00525941	0.0624462	0.0624462
Onchocerca volvulus		0.0148042	0.300864	0.448891
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.00760665	0.121078	0.173336
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.00760665	0.121078	0.163894
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.00350879	0.0187176	0.0155546
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.00409786	0.0334319	0.0368784
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	amine GPCR	0.0030791	0.00798432	0.00798432
Onchocerca volvulus		0.00350879	0.0187176	0.0164508
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0030791	0.00798432	0.00798432
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.00525941	0.0624462	0.0789256
Loa Loa (eye worm)	GABA receptor subunit	0.00409786	0.0334319	0.0368784
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.00409786	0.0334319	0.0368784
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0030791	0.00798432	0.00798432
Echinococcus multilocularis	glycine receptor subunit beta	0.00760665	0.121078	0.173336
Loa Loa (eye worm)	hypothetical protein	0.0045535	0.0448134	0.0533723
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Brugia malayi	Receptor family ligand binding region containing protein	0.0051696	0.0602029	0.0756747
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0030791	0.00798432	0.00798432
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0291992	0.660436	1
Onchocerca volvulus		0.00339613	0.0159036	0.0121377
Loa Loa (eye worm)	hypothetical protein	0.00585131	0.0772311	0.100352
Onchocerca volvulus		0.00760665	0.121078	0.173336
Echinococcus granulosus	glycine receptor subunit beta	0.00760665	0.121078	0.173336
Echinococcus multilocularis	GPCR, family 2	0.00483598	0.0518694	0.0672618
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.00339613	0.0159036	0.5
Schistosoma mansoni	inhibitor of apoptosis protein	0.00525941	0.0624462	0.0624462
Brugia malayi	Calcitonin receptor-like protein seb-1	0.030704	0.698025	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	hypothetical protein	0.00731296	0.113741	0.153262
Mycobacterium leprae	probable zinc metalloprotease	0.00731296	0.113741	0.5
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0291992	0.660436	1
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.00350879	0.0187176	0.0164508
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.00760665	0.121078	0.121078
Schistosoma mansoni	neuropeptide receptor	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Schistosoma mansoni	adenoreceptor	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	hypothetical protein	0.00483598	0.0518694	0.0518694
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0030791	0.00798432	0.00798432
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0080822	0.132956	0.191542
Schistosoma mansoni	hypothetical protein	0.0080822	0.132956	0.132956
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0051696	0.0602029	0.0756747
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.00760665	0.121078	0.173336
Echinococcus granulosus	endothelin converting enzyme 1	0.00731296	0.113741	0.162092
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.00760665	0.121078	0.173336
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0030791	0.00798432	0.00798432
Toxoplasma gondii	PAN domain-containing protein	0.0290735	0.657297	1
Mycobacterium ulcerans	zinc metalloprotease	0.00731296	0.113741	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.00483598	0.0518694	0.0635978
Schistosoma mansoni	amine GPCR	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.00760665	0.121078	0.163894
Schistosoma mansoni	hypothetical protein	0.00483598	0.0518694	0.0518694
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.00760665	0.121078	0.163894
Onchocerca volvulus		0.0148042	0.300864	0.448891
Brugia malayi	hypothetical protein	0.00350879	0.0187176	0.0155546
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	hypothetical protein	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	myosin xvIII	0.0030791	0.00798432	0.00798432
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	hypothetical protein	0.0291992	0.660436	0.945527
Loa Loa (eye worm)	hypothetical protein	0.00350879	0.0187176	0.0155546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0030791	0.00798432	0.00798432
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0291992	0.660436	0.945527
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.00760665	0.121078	0.163894
Schistosoma mansoni	hypothetical protein	0.00525941	0.0624462	0.0624462
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.00760665	0.121078	0.173336
Loa Loa (eye worm)	latrophilin receptor protein 2	0.00483598	0.0518694	0.0635978
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.00339613	0.0159036	0.0121377
Loa Loa (eye worm)	hypothetical protein	0.00409786	0.0334319	0.0368784
Echinococcus granulosus	aminopeptidase N	0.0114646	0.217446	0.321038
Loa Loa (eye worm)	hypothetical protein	0.00760665	0.121078	0.163894
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.00339613	0.0159036	0.5
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.00339613	0.0159036	0.0121377
Loa Loa (eye worm)	hypothetical protein	0.00409786	0.0334319	0.0368784
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0148042	0.300864	0.300864
Brugia malayi	hypothetical protein	0.00350879	0.0187176	0.0155546

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.42 ng ml-1	Compound was evaluated in vitro for antimalarial activity against Indochina clone (W-2) of P. falciparum.	ChEMBL.	1578492
IC50 (functional)	= 0.42 ng ml-1	Compound was evaluated in vitro for antimalarial activity against Indochina clone (W-2) of P. falciparum.	ChEMBL.	1578492
IC50 (functional)	= 1.11 ng ml-1	Compound was evaluated in vitro for antimalarial activity against Sierra Leone clone (D-6) of P. falciparum.	ChEMBL.	1578492
IC50 (functional)	= 1.11 ng ml-1	Compound was evaluated in vitro for antimalarial activity against Sierra Leone clone (D-6) of P. falciparum.	ChEMBL.	1578492
No. of mice cured (functional)	= 1	Antimalarial activity of the compound against P. berghei in mice at 20 mg/kg dose per day (Out of 5 mice taken)	ChEMBL.	1578492
No. of mice cured (functional)	= 4	Antimalarial activity of the compound against P. berghei in mice at 320 mg/kg dose per day (Out of 5 mice taken)	ChEMBL.	1578492
No. of mice cured (functional)	= 5	Antimalarial activity of the compound against P. berghei in mice at 80 mg/kg dose per day (Out of 5 mice taken)	ChEMBL.	1578492
No. of mice cured (functional)	= 1	Antimalarial activity of the compound against P. berghei in mice at 20 mg/kg dose per day (Out of 5 mice taken)	ChEMBL.	1578492
No. of mice cured (functional)	= 4	Antimalarial activity of the compound against P. berghei in mice at 320 mg/kg dose per day (Out of 5 mice taken)	ChEMBL.	1578492
No. of mice cured (functional)	= 5	Antimalarial activity of the compound against P. berghei in mice at 80 mg/kg dose per day (Out of 5 mice taken)	ChEMBL.	1578492

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	1578492

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL288656

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 62698