Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0128 | 0.0354 |
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.1073 | 0.2955 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0303 | 0.0834 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0456 | 0.3633 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0303 | 0.0834 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0262 | 0.1997 | 0.5496 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0041 | 0.0128 | 0.0354 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0303 | 0.0834 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0041 | 0.0128 | 0.0354 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0128 | 0.0354 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.016 | 0.044 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0164 | 0.1162 | 0.3199 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0153 | 0.1073 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.0303 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.1073 | 0.2955 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0128 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0128 | 0.0354 |
Schistosoma mansoni | eyes absent homolog | 0.0097 | 0.0597 | 0.1644 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0456 | 0.3633 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0041 | 0.0128 | 0.0354 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0456 | 0.3633 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0128 | 0.0354 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.016 | 0.044 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0303 | 0.0834 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0456 | 0.3633 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0456 | 0.3633 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0128 | 0.0354 |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.1073 | 0.2955 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0041 | 0.0128 | 0.0354 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0128 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1073 | 0.2955 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1073 | 0.2955 |
Onchocerca volvulus | 0.0041 | 0.0128 | 0.0128 | |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0041 | 0.0128 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0128 | 0.1196 |
Mycobacterium ulcerans | hypothetical protein | 0.0456 | 0.3633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0128 | 0.1196 |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.1073 | 0.2955 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0041 | 0.0128 | 0.0354 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0128 | 0.0354 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0128 | 0.0354 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.016 | 0.044 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0303 | 0.0834 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0041 | 0.0128 | 0.0354 |
Onchocerca volvulus | 0.0041 | 0.0128 | 0.0128 | |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0597 | 0.5564 |
Giardia lamblia | Hypothetical protein | 0.0456 | 0.3633 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0597 | 0.5564 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0128 | 0.1196 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium ulcerans | hypothetical protein | 0.0456 | 0.3633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0128 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1073 | 1 |
Brugia malayi | hypothetical protein | 0.0097 | 0.0597 | 0.1644 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0303 | 0.0834 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0128 | 0.0354 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0153 | 0.1073 | 0.2955 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0128 | 0.0354 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0128 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0456 | 0.3633 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.016 | 0.044 |
Brugia malayi | Thioredoxin family protein | 0.0456 | 0.3633 | 1 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0456 | 0.3633 | 1 |
Onchocerca volvulus | 0.0041 | 0.0128 | 0.0128 | |
Mycobacterium tuberculosis | Long conserved protein | 0.0456 | 0.3633 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0153 | 0.1073 | 0.2955 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.016 | 0.1487 |
Echinococcus multilocularis | Transglutaminase | 0.0456 | 0.3633 | 1 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0456 | 0.3633 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0128 | 0.1196 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.016 | 0.044 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0456 | 0.3633 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.016 | 0.044 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0128 | 0.0354 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0128 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1073 | 1 |
Echinococcus granulosus | Transglutaminase | 0.0456 | 0.3633 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0128 | 0.1196 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.016 | 0.044 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0303 | 0.0834 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1073 | 0.2955 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0128 | 0.0354 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0128 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.016 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0128 | 0.1196 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0164 | 0.1162 | 0.3199 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0303 | 0.0834 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0128 | 0.0354 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0456 | 0.3633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0128 | 0.1196 |
Schistosoma mansoni | hypothetical protein | 0.0456 | 0.3633 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.1073 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.