Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kallikrein 1 | Starlite/ChEMBL | References |
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protein C (inactivator of coagulation factors Va and VIIIa) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | kallikrein 1 | 262 aa | 247 aa | 22.7 % |
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0175 | 1 | 1 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0175 | 1 | 1 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0102 | 0.4853 | 0.4853 |
Brugia malayi | Protein kinase domain containing protein | 0.0048 | 0.1093 | 0.1093 |
Echinococcus granulosus | Mastin | 0.0073 | 0.2877 | 0.2877 |
Onchocerca volvulus | 0.0134 | 0.7111 | 1 | |
Trypanosoma brucei | N-myristoyltransferase | 0.0175 | 1 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0175 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0073 | 0.2877 | 0.2877 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1093 | 0.1093 |
Leishmania major | N-myristoyl transferase, putative | 0.0175 | 1 | 1 |
Echinococcus multilocularis | Mastin | 0.0073 | 0.2877 | 0.2877 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0048 | 0.1093 | 0.1093 |
Echinococcus granulosus | enteropeptidase | 0.0073 | 0.2877 | 0.2877 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.108 | 0.108 |
Echinococcus multilocularis | CREB binding protein | 0.007 | 0.2619 | 0.2619 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0175 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0175 | 1 | 1 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.7111 | 0.7111 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0073 | 0.2877 | 0.2877 |
Echinococcus granulosus | CREB binding protein | 0.0102 | 0.4853 | 0.4853 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0102 | 0.4853 | 0.4853 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0175 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0073 | 0.2877 | 0.2877 |
Brugia malayi | Kringle domain containing protein | 0.0048 | 0.1093 | 0.1093 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0175 | 1 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0048 | 0.1093 | 0.1093 |
Schistosoma mansoni | N-myristoyltransferase | 0.0175 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0134 | 0.7111 | 0.7111 |
Echinococcus granulosus | CREB binding protein | 0.0063 | 0.2128 | 0.2128 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0048 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.7111 | 0.7111 |
Brugia malayi | TAZ zinc finger family protein | 0.0102 | 0.4853 | 0.4853 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0134 | 0.7111 | 0.7111 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | CBP-B | 0.0071 | 0.268 | 0.268 |
Onchocerca volvulus | 0.0106 | 0.5189 | 0.7298 | |
Toxoplasma gondii | kringle domain-containing protein | 0.0048 | 0.1093 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0073 | 0.2877 | 0.2877 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0175 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0.1093 | 0.1537 | |
Giardia lamblia | CDC72 | 0.0175 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0134 | 0.7111 | 0.7111 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 nM | Inhibitory activity against coagulation factor Xa | ChEMBL. | 12039583 |
IC50 (binding) | = 6 nM | Inhibitory activity against coagulation factor Xa | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against thrombin | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against trypsin | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against tissue plasminogen activator | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against activated protein C | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against plasmin | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against kallikrein | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against thrombin | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against trypsin | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against tissue plasminogen activator | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against activated protein C | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against plasmin | ChEMBL. | 12039583 |
IC50 (binding) | > 11 uM | Inhibitory activity against kallikrein | ChEMBL. | 12039583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.