Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1526 | 0.1023 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0561 | 0.1256 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.05 | 0.1097 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.05 | 0.1097 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0561 | 0.0561 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.1696 | 0.1696 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0123 | 0.3916 | 0.6041 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.0582 | 0.0146 |
Plasmodium vivax | RNA helicase-1, putative | 0.0123 | 0.3916 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0561 | 0.1256 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0561 | 0.0064 |
Mycobacterium tuberculosis | Probable reductase | 0.0087 | 0.2508 | 0.2394 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.5577 | 0.5577 |
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.05 | 0.1097 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0067 | 0.1696 | 0.3501 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0087 | 0.2508 | 0.2394 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.1696 | 0.1696 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0087 | 0.2508 | 0.8347 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0097 | 0.2893 | 0.2868 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.05 | 0.1097 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0561 | 0.1256 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0123 | 0.3916 | 0.6041 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1526 | 0.1023 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0087 | 0.2508 | 0.2394 |
Plasmodium falciparum | thioredoxin reductase | 0.0038 | 0.0567 | 0.1271 |
Schistosoma mansoni | ets-related | 0.0222 | 0.7857 | 0.7751 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.5577 | 0.8979 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0561 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0561 | 0.1256 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1526 | 0.1108 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0038 | 0.0567 | 0.1271 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.047 | 0.047 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0123 | 0.3916 | 0.6041 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1532 | 0.1532 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1526 | 0.1108 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0123 | 0.3916 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1127 | 0.1127 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0087 | 0.2508 | 0.2394 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0561 | 0.0095 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0038 | 0.0567 | 0.0007 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0123 | 0.3916 | 0.3615 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0079 | 0.0079 |
Plasmodium vivax | glutathione reductase, putative | 0.0038 | 0.0567 | 0.1271 |
Echinococcus granulosus | geminin | 0.0179 | 0.6154 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0561 | 0.0561 |
Trypanosoma brucei | trypanothione reductase | 0.0038 | 0.0567 | 0.1271 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0561 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0561 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0123 | 0.3916 | 0.4125 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0561 | 0.0561 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.6154 | 0.5965 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0561 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0073 | 0.1952 | 0.2569 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.0587 | 0.0154 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0561 | 0.0561 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.6154 | 0.5965 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.1526 | 0.3773 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0561 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0561 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.5577 | 0.8979 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0038 | 0.0567 | 0.0567 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0123 | 0.3916 | 0.3615 |
Loa Loa (eye worm) | glutathione reductase | 0.0038 | 0.0567 | 0.0567 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0123 | 0.3916 | 0.3595 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0087 | 0.2508 | 0.2394 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.1526 | 0.1816 |
Plasmodium falciparum | glutathione reductase | 0.0038 | 0.0567 | 0.1271 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0079 | 0.0079 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0123 | 0.3916 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0276 | 1 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.0582 | 0.0146 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0123 | 0.3916 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0123 | 0.3916 | 0.3595 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0123 | 0.3916 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1127 | 0.1127 |
Schistosoma mansoni | gabp alpha | 0.0073 | 0.1952 | 0.1555 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0561 | 0.0561 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.1696 | 0.1286 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1127 | 0.1127 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0097 | 0.2893 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0123 | 0.3916 | 1 |
Schistosoma mansoni | glutaminase | 0.0276 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.5577 | 0.8979 |
Loa Loa (eye worm) | fli-1 protein | 0.0222 | 0.7857 | 0.7857 |
Leishmania major | trypanothione reductase | 0.0038 | 0.0567 | 0.1271 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0561 | 0.1256 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.05 | 0.0031 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0561 | 0.0064 |
Loa Loa (eye worm) | glutaminase | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0073 | 0.1952 | 0.1952 |
Brugia malayi | Fli-1 protein | 0.0222 | 0.7857 | 0.7857 |
Trichomonas vaginalis | glutaminase, putative | 0.0276 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0038 | 0.0567 | 0.1271 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0561 | 0.0064 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0561 | 0.0561 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0123 | 0.3916 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0087 | 0.2508 | 0.2394 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.5577 | 0.5577 |
Echinococcus multilocularis | geminin | 0.0179 | 0.6154 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0123 | 0.3916 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.05 | 0.1097 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.1526 | 0.1187 |
Onchocerca volvulus | 0.0095 | 0.2826 | 0.6752 | |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.0567 | 0.0567 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.0587 | 0.0154 |
Schistosoma mansoni | alpha-glucosidase | 0.0142 | 0.4668 | 0.4405 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0123 | 0.3916 | 0.6041 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0123 | 0.3916 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.3916 | 0.3916 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0123 | 0.3916 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1696 | 0.2115 |
Mycobacterium ulcerans | glutaminase | 0.0276 | 1 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.1952 | 0.1952 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0097 | 0.2893 | 0.2868 |
Schistosoma mansoni | alpha-glucosidase | 0.0142 | 0.4668 | 0.4405 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0123 | 0.3916 | 0.3916 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1696 | 0.4214 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 0.2893 | 0.2868 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0067 | 0.1696 | 0.4214 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0073 | 0.1952 | 0.2569 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.1952 | 0.1952 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1696 | 0.4214 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1696 | 0.4214 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0561 | 0.0108 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.05 | 0.05 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0243 | 0.8693 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.05 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0561 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0123 | 0.3916 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0038 | 0.0567 | 0.1271 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0561 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0561 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0561 | 0.1256 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1696 | 0.2115 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.1526 | 0.1816 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1526 | 0.1023 |
Brugia malayi | glutathione reductase | 0.0038 | 0.0567 | 0.0567 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0123 | 0.3916 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.1526 | 0.3773 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0561 | 0.0064 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0123 | 0.3916 | 0.3595 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0561 | 0.0064 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.