Detailed information for compound 652035

Basic information

Technical information
  • TDR Targets ID: 652035
  • Name: 4-methyl-N-(2,3,5-trichloro-4-hydroxyphenyl)b enzenesulfonamide
  • MW: 366.647 | Formula: C13H10Cl3NO3S
  • H donors: 2 H acceptors: 3 LogP: 4.34 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1cc(Cl)c(c(c1Cl)Cl)O
  • InChi: 1S/C13H10Cl3NO3S/c1-7-2-4-8(5-3-7)21(19,20)17-10-6-9(14)13(18)12(16)11(10)15/h2-6,17-18H,1H3
  • InChiKey: OQDKJHNFJNVPTA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methyl-N-(2,3,5-trichloro-4-hydroxy-phenyl)benzenesulfonamide
  • T0502-6718
  • 4-Methyl-N-(2,3,5-trichloro-4-hydroxy-phenyl)-benzenesulfonamide
  • AIDS-185664
  • AIDS185664
  • ZINC01232927
  • CBDivE_011664

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0746 0.6043 0.6043
Schistosoma mansoni glutamate receptor kainate 0.0618 0.4759 0.4935
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0746 0.6043 0.6043
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0198 0.0198
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.1064 0.2237
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.084 0.6985 0.6985
Echinococcus multilocularis glutamate receptor NMDA 0.0359 0.2164 0.2164
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.025 0.107 0.107
Loa Loa (eye worm) hypothetical protein 0.0163 0.0198 0.0416
Toxoplasma gondii histone deacetylase HDAC2 0.0143 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0205 0.1922
Trypanosoma cruzi histone deacetylase 1, putative 0.0143 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0293 0.2752
Schistosoma mansoni ATP-binding cassette transporter 0.0618 0.4759 0.4935
Loa Loa (eye worm) glutamate receptor 1 0.0618 0.4759 1
Schistosoma mansoni glutamate receptor AMPA 0.0618 0.4759 0.4935
Plasmodium vivax histone deacetylase 1, putative 0.0143 0 0.5
Brugia malayi Glutamate receptor 2 precursor 0.0618 0.4759 1
Echinococcus multilocularis NMDA receptor 0.025 0.107 0.107
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0532 0.3894 0.5
Schistosoma mansoni glutamate receptor kainate 0.0618 0.4759 0.4935
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0746 0.6043 0.6043
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0205 0.1922
Echinococcus granulosus glutamate receptor NMDA 0.0359 0.2164 0.2164
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0532 0.3894 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0746 0.6043 0.6043
Echinococcus granulosus glutamate receptor 2 0.0496 0.3538 0.3538
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0205 0.1922
Brugia malayi follicle stimulating hormone receptor 0.0224 0.0806 0.1695
Echinococcus granulosus glutamate receptor ionotropic kainate 0.025 0.107 0.107
Schistosoma mansoni glutamate receptor NMDA 0.1106 0.9643 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0532 0.3894 0.5
Schistosoma mansoni glutamate receptor NMDA 0.0618 0.4759 0.4935
Giardia lamblia Histone deacetylase 0.0143 0 0.5
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0746 0.6043 0.6043
Echinococcus granulosus nmda type glutamate receptor 0.0487 0.3449 0.3449
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1064 1
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.025 0.107 0.107
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0746 0.6043 0.6043
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0618 0.4759 0.4759
Toxoplasma gondii histone deacetylase HDAC3 0.0143 0 0.5
Trypanosoma brucei histone deacetylase 1 0.0143 0 0.5
Trypanosoma cruzi histone deacetylase 1, putative 0.0143 0 0.5
Echinococcus granulosus glutamate receptor subunit protein glur 0.025 0.107 0.107
Echinococcus granulosus glutamate receptor 2 0.0746 0.6043 0.6043
Echinococcus multilocularis glutamate receptor 2 0.0618 0.4759 0.4759
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0205 0.1922
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0205 0.1922
Schistosoma mansoni hypothetical protein 0.025 0.107 0.111
Schistosoma mansoni glutamate receptor AMPA 0.0618 0.4759 0.4935
Schistosoma mansoni glutamate receptor kainate 0.0618 0.4759 0.4935
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1064 1
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0293 0.2752
Plasmodium falciparum histone deacetylase 1 0.0143 0 0.5
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0205 0.5
Echinococcus granulosus glutamate NMDA receptor subunit 0.0618 0.4759 0.4759
Loa Loa (eye worm) hypothetical protein 0.0163 0.0198 0.0416
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1064 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.025 0.107 0.107
Chlamydia trachomatis glutamine binding protein 0.0532 0.3894 0.5
Echinococcus multilocularis muscleblind protein 0.0163 0.0198 0.0198
Echinococcus multilocularis nmda type glutamate receptor 0.0487 0.3449 0.3449
Leishmania major histone deacetylase, putative 0.0143 0 0.5
Echinococcus multilocularis glutamate receptor 2 0.0496 0.3538 0.3538
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.0806 0.1695
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0205 0.1922
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0205 0.1922
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0746 0.6043 0.6043
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.1064 0.2237
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.025 0.107 0.107
Echinococcus multilocularis nmda type glutamate receptor 0.1141 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1064 1
Brugia malayi Glutamate receptor 1 precursor 0.0618 0.4759 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0532 0.3894 0.5
Echinococcus multilocularis glutamate receptor 2 0.0746 0.6043 0.6043
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1064 1
Echinococcus granulosus muscleblind protein 0.0163 0.0198 0.0198
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0746 0.6043 0.6043
Brugia malayi Muscleblind-like protein 0.0163 0.0198 0.0416
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1064 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0532 0.3894 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0782 0.64 0.64
Echinococcus multilocularis glutamate receptor subunit protein glur 0.025 0.107 0.107
Leishmania major histone deacetylase, putative 0.0143 0 0.5
Loa Loa (eye worm) glutamate receptor 2 0.0618 0.4759 1
Entamoeba histolytica histone deacetylase, putative 0.0143 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.