Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Phosphodiesterase 4A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | SH3 domain-binding glutamic acid-rich protein homolog | Phosphodiesterase 4A | 118 aa | 112 aa | 28.6 % |
Candida albicans | similar to a group of Candida orfs that show weak similarity to Leucine-rich repeat viral proteins | Phosphodiesterase 4A | 118 aa | 97 aa | 26.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glycogen phosphorylase | 0.1156 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.1156 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.1156 | 1 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.1156 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.1156 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1156 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1156 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1156 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.1156 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1156 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1156 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.1156 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.1156 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.1156 | 1 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.05 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.05 | 0 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.1156 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1156 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.24 uM | Inhibitory potency against pig aortic PDE IV | ChEMBL. | 8201604 |
IC50 (binding) | = 0.24 uM | Inhibitory potency against pig aortic PDE IV | ChEMBL. | 8201604 |
IC50 (binding) | > 1000 uM | Inhibitory potency against pig aortic PDE I. | ChEMBL. | 8201604 |
IC50 (binding) | > 1000 uM | Inhibitory potency against pig aortic PDE III. | ChEMBL. | 8201604 |
IC50 (binding) | > 1000 uM | Inhibitory potency against pig aortic PDE V. | ChEMBL. | 8201604 |
IC50 (binding) | > 1000 uM | Inhibitory potency against pig aortic PDE I. | ChEMBL. | 8201604 |
IC50 (binding) | > 1000 uM | Inhibitory potency against pig aortic PDE V. | ChEMBL. | 8201604 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.