Detailed information for compound 655335

Basic information

Technical information
  • TDR Targets ID: 655335
  • Name: ethyl 2-[4-methyl-2-oxo-3-(phenylmethyl)chrom en-7-yl]oxypropanoate
  • MW: 366.407 | Formula: C22H22O5
  • H donors: 0 H acceptors: 2 LogP: 4.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(Oc1ccc2c(c1)oc(=O)c(c2C)Cc1ccccc1)C
  • InChi: 1S/C22H22O5/c1-4-25-21(23)15(3)26-17-10-11-18-14(2)19(22(24)27-20(18)13-17)12-16-8-6-5-7-9-16/h5-11,13,15H,4,12H2,1-3H3
  • InChiKey: UCFKDEBRZDWNIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-methyl-2-oxo-3-(phenylmethyl)-7-chromenyl]oxy]propanoic acid ethyl ester
  • 2-[3-(benzyl)-2-keto-4-methyl-chromen-7-yl]oxypropionic acid ethyl ester
  • EU-0001370
  • Oprea1_117603

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0028 0.0335 0.0704
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0445 0.0404
Loa Loa (eye worm) sugar transporter 0.0015 0.0042 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Schistosoma mansoni P2X receptor subunit 0.0151 0.3104 0.7377
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0061 0.1074 0.2562
Loa Loa (eye worm) acetylcholine receptor protein 0.0028 0.0335 0.0798
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0061 0.1074 0.337
Onchocerca volvulus 0.0028 0.0335 0.0704
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0061 0.1074 0.2562
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0445 0.0404
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0042 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1052
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.1263
Brugia malayi Cation transporter family protein 0.0199 0.4192 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.8107
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.0441 0.096
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0429 0.1855
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0444 0.1312
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0061 0.1074 0.2486
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0061 0.1074 0.2486
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0028 0.0335 0.0704
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0028 0.0335 0.0954
Brugia malayi hypothetical protein 0.0028 0.0335 0.0704
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0199 0.4192 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0061 0.1074 0.2562
Echinococcus multilocularis p2X purinoceptor 4 0.0151 0.3104 1
Schistosoma mansoni protein kinase 0.0033 0.0444 0.0968
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1312
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0444 0.0968
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2128 0.6811
Plasmodium vivax CDK-related protein kinase 6, putative 0.0457 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0579
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0174 0.3622 0.5495
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0429 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1052
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0444 0.0968
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0932
Echinococcus multilocularis glycine receptor subunit beta 0.0061 0.1074 0.337
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0061 0.1074 0.337
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0061 0.1074 0.2486
Echinococcus granulosus glycine receptor subunit alpha 1 0.0061 0.1074 0.337
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0243 0.5182
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.055 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.1263
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0445 0.0404
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.1074 0.2486
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.8107
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Schistosoma mansoni nAChR subunit 0.0061 0.1074 0.2486
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0243 0.3046
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1312
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0243 0.0655
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1052
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0061 0.1074 0.2486
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0061 0.1074 0.337
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.2128 0.6811
Plasmodium falciparum proline--tRNA ligase 0.0038 0.055 0.051
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0483
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0445 0.0404
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.2128 0.6811
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0061 0.1074 0.337
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0445 0.0617
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.8107
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0444 0.106
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0061 0.1074 0.337
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0028 0.0335 0.0954
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0243 0.0655
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.8107
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0061 0.1074 0.337
Loa Loa (eye worm) LGC-31 protein 0.0061 0.1074 0.2562
Echinococcus granulosus glycine receptor subunit alpha 1 0.0061 0.1074 0.337
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1312
Echinococcus granulosus glycine receptor subunit alpha 1 0.0061 0.1074 0.337
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0028 0.0335 0.0704
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.8107
Loa Loa (eye worm) ACC-1 protein 0.0061 0.1074 0.2562
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0101
Toxoplasma gondii protein kinase, putative 0.0304 0.6557 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0061 0.1074 0.337
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.2128 0.6811
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0028 0.0335 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Trypanosoma brucei glucose transporter 2A 0.0033 0.0454 0.8107
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0444 0.7919
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Leishmania major glucose transporter, lmgt2 0.0033 0.0454 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.2128 0.6811
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0199 0.4192 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.4192 1
Plasmodium falciparum hexose transporter 0.0108 0.2128 0.2094
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0061 0.1074 0.337
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Echinococcus granulosus p2X purinoceptor 4 0.0151 0.3104 1
Schistosoma mansoni protein kinase 0.0033 0.0444 0.0968
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0243 0.5
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0033 0.0441 0.096
Schistosoma mansoni nAChR subunit 0.0061 0.1074 0.2486
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0454 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0113 0.1383
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.1074 0.2486
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0445 0.0617
Echinococcus granulosus nAChR subunit 0.0061 0.1074 0.337
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0028 0.0335 0.0704
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0243 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.2128 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0444 1
Leishmania major glucose transporter, lmgt1 0.0033 0.0454 0.8107
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.8107
Echinococcus granulosus glycine receptor subunit beta 0.0061 0.1074 0.337
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.2128 0.3201
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0483
Schistosoma mansoni glucose transport protein 0.0108 0.2128 0.5025
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.055 0.051
Onchocerca volvulus 0.0061 0.1074 0.2486
Onchocerca volvulus Putative nachr subunit 0.0061 0.1074 0.2486
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.0698
Brugia malayi Cam kinase protein 1 0.0033 0.0444 0.0968
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Echinococcus multilocularis p2X purinoceptor 4 0.0151 0.3104 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Echinococcus multilocularis nAChR subunit 0.0033 0.0441 0.1302
Onchocerca volvulus 0.0199 0.4192 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1312
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0061 0.1074 0.337
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2128 0.6811
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.055 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0028 0.0335 0.0954
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0061 0.1074 0.337
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1052
Echinococcus granulosus nAChR subunit 0.0033 0.0441 0.1302
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0028 0.0335 0.0704
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1052
Leishmania major glucose transporter, lmgt3 0.0033 0.0454 0.8107
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.0932
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.055 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Schistosoma mansoni glucose transport protein 0.0108 0.2128 0.5025
Echinococcus multilocularis p2X purinoceptor 4 0.0151 0.3104 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0061 0.1074 0.337
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.8107
Schistosoma mansoni nAChR subunit 0.0061 0.1074 0.2486
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.1074 0.2486
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Loa Loa (eye worm) GABA receptor subunit 0.0033 0.0441 0.1052
Schistosoma mansoni nAChR subunit 0.0061 0.1074 0.2486
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0398 0.1162
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0243 0.0308
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0161 1
Onchocerca volvulus 0.0033 0.0441 0.096
Echinococcus multilocularis nAChR subunit 0.0061 0.1074 0.337
Schistosoma mansoni acetylcholine receptor subunit beta 0.0028 0.0335 0.0704
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Trypanosoma cruzi hexose transporter 0.0033 0.0454 0.8107
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0061 0.1074 0.2562
Schistosoma mansoni acetylcholine receptor-related 0.0028 0.0335 0.0704
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0061 0.1074 0.2486
Brugia malayi hypothetical protein 0.0028 0.0335 0.0704
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0061 0.1074 0.2486
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 1
Brugia malayi hypothetical protein 0.0028 0.0335 0.0704
Brugia malayi Sugar transporter family protein 0.0108 0.2128 0.5025
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0445 0.0404
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.8107
Onchocerca volvulus 0.0061 0.1074 0.2486
Schistosoma mansoni glucose transport protein 0.0108 0.2128 0.5025
Onchocerca volvulus 0.0028 0.0335 0.0704
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0028 0.0335 0.0798
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0061 0.1074 0.2486
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Loa Loa (eye worm) ACC-1 protein 0.0061 0.1074 0.2562
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0445 0.0404
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0061 0.1074 0.2486
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0176 0.0641
Trypanosoma brucei glucose transporter 1E 0.0033 0.0454 0.8107
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0445 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1312
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.8107
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0429 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1052
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.1024
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0061 0.1074 0.337
Echinococcus granulosus p2X purinoceptor 4 0.0151 0.3104 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0161 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0028 0.0335 0.0954
Loa Loa (eye worm) hypothetical protein 0.0033 0.0444 0.106
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0335 0.0704
Echinococcus granulosus General substrate transporter 0.0093 0.1787 0.5697
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0033 0.0441 0.096
Onchocerca volvulus 0.0033 0.0441 0.096
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1312
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0061 0.1074 0.2486
Brugia malayi hypothetical protein 0.0028 0.0335 0.0704
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.055 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.1074 0.2486
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.055 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0028 0.0335 0.0704
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.1024
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0061 0.1074 0.2486
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Onchocerca volvulus 0.0061 0.1074 0.2486
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0061 0.1074 0.337
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.8107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.1074 0.2486
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0243 0.395
Loa Loa (eye worm) hypothetical protein 0.0171 0.3559 0.8489
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.0932
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0061 0.1074 0.337
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.1312
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0061 0.1074 0.2486
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0061 0.1074 0.337
Schistosoma mansoni nAChR subunit 0.0028 0.0335 0.0704
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0174 0.3622 0.3595
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0061 0.1074 0.2562
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0243 0.395
Entamoeba histolytica protein kinase, putative 0.0033 0.0444 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0033 0.0441 0.096
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0932
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0028 0.0335 0.0954
Leishmania major protein kinase, putative 0.0033 0.0444 0.7919
Brugia malayi excitatory GABA receptor EXP-1A 0.0061 0.1074 0.2486
Brugia malayi hypothetical protein 0.0028 0.0335 0.0704
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0199 0.4192 1
Echinococcus granulosus p2X purinoceptor 4 0.0151 0.3104 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2128 0.6811
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Schistosoma mansoni nAChR subunit 0.0061 0.1074 0.2486
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.0441 0.096
Loa Loa (eye worm) sugar transporter 0.0108 0.2128 0.5075
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0335 0.0704
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0445 0.0617
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0033 0.0441 0.096
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Onchocerca volvulus 0.0199 0.4192 1
Plasmodium falciparum protein kinase 7 0.0304 0.6557 0.6542
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0061 0.1074 0.2486
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Brugia malayi Cation transporter family protein 0.0061 0.1074 0.2486
Plasmodium falciparum mitogen-activated protein kinase 2 0.0174 0.3622 0.3595
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.8107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0028 0.0335 0.0704
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2128 0.6811
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.055 0.0779
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0429 0.9253
Plasmodium vivax hexose transporter 0.0108 0.2128 0.2094
Entamoeba histolytica hypothetical protein 0.0033 0.0441 0.9836
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0243 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0444 0.1927
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.0441 0.096
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0398 0.1162
Schistosoma mansoni P2X receptor subunit 0.0151 0.3104 0.7377
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Echinococcus granulosus glycine receptor subunit beta 0.0061 0.1074 0.337
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0061 0.1074 0.337
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0061 0.1074 0.2486
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0061 0.1074 0.337
Loa Loa (eye worm) hypothetical protein 0.0061 0.1074 0.2562
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0061 0.1074 0.2562
Echinococcus multilocularis glycine receptor subunit beta 0.0061 0.1074 0.337
Schistosoma mansoni hypothetical protein 0.0108 0.2128 0.5025
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0061 0.1074 0.2486
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0101
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Loa Loa (eye worm) hypothetical protein 0.0033 0.0441 0.1052
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0243 0.0961
Echinococcus multilocularis General substrate transporter 0.0093 0.1787 0.5697
Onchocerca volvulus 0.0199 0.4192 1
Schistosoma mansoni nAChR subunit 0.0061 0.1074 0.2486
Schistosoma mansoni nAChR subunit 0.0028 0.0335 0.0704
Schistosoma mansoni P2X receptor subunit 0.0151 0.3104 0.7377
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0243 0.0483
Schistosoma mansoni P2X receptor subunit 0.0151 0.3104 0.7377
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0243 0.395
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0101
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0061 0.1074 0.337
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0444 0.106
Schistosoma mansoni nAChR subunit 0.0061 0.1074 0.2486
Brugia malayi Cation transporter family protein 0.0061 0.1074 0.2486
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.1074 0.2486
Schistosoma mansoni protein kinase 0.0033 0.0444 0.0968
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0798

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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