Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.3587 | 0.4734 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.3587 | 0.4572 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3698 | 0.4014 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.2635 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.5115 | 0.5552 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9213 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2814 | 0.3603 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.2635 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0351 | 0.0448 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.2296 | 0.2926 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.2635 | 0.3341 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.3587 | 0.4734 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.5115 | 0.4698 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.2635 | 0.3359 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4049 | 0.4395 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.3587 | 0.4572 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.2296 | 0.1638 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.3587 | 0.3039 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.3587 | 0.4572 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.3587 | 0.4734 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7844 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7186 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2814 | 0.3603 |
Brugia malayi | hypothetical protein | 0.0042 | 0.2635 | 0.2006 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.2635 | 0.3341 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.2635 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.5115 | 0.5552 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.5115 | 0.4698 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.2635 | 0.3359 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.3587 | 0.3893 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7186 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3249 | 0.2673 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.2635 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.3587 | 0.4734 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2296 | 0.2492 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3262 | 0.3541 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.