TDR Targets

Basic information

Technical information

TDR Targets ID: 658573
Name: (4-iodophenyl)-morpholin-4-ylmethanone
MW: 317.123 | Formula: C11H12INO2
H donors: 0 H acceptors: 1 LogP: 1.66 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)I)N1CCOCC1
InChi: 1S/C11H12INO2/c12-10-3-1-9(2-4-10)11(14)13-5-7-15-8-6-13/h1-4H,5-8H2
InChiKey: KSNSOBKZQVFSQT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4-iodophenyl)-morpholino-methanone
(4-iodophenyl)-morpholinomethanone
(4-iodophenyl)-morpholin-4-yl-methanone
CBMicro_002170
BIM-0002047.P001
ZINC00256790
T0500-4941

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.0167	0.4367	1
Onchocerca volvulus		0.0042	0.0693	0.5
Echinococcus granulosus	lysine specific demethylase 5A	0.0066	0.139	0.139
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0071	0.1553	0.1553
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0693	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.01	0.2415	0.2592
Entamoeba histolytica	hypothetical protein	0.0036	0.0523	0.0804
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0447	0.4584
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.0167	0.4367	0.4367
Leishmania major	macrophage migration inhibitory factor-like protein	0.0167	0.4367	1
Leishmania major	macrophage migration inhibitory factor-like protein	0.0167	0.4367	1
Plasmodium falciparum	thioredoxin reductase	0.0044	0.0755	0.136
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0693	0.0693
Loa Loa (eye worm)	hypothetical protein	0.004	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0693	0.0693
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.0167	0.4367	1
Trichomonas vaginalis	conserved hypothetical protein	0.0167	0.4367	1
Leishmania major	trypanothione reductase	0.0044	0.0755	0.136
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0693	0.0693
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0693	0.1586
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0693	0.1211
Entamoeba histolytica	hypothetical protein	0.0036	0.0523	0.0804
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.0167	0.4367	1
Schistosoma mansoni	ran	0.0025	0.0187	0.0187
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0965	0.0965
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0261	0.0177
Mycobacterium ulcerans	lipase LipD	0.0042	0.0693	0.5
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.01	0.2415	0.2592
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0066	0.139	0.139
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0071	0.1553	0.1553
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.1167	0.1167
Brugia malayi	RNA, U transporter 1	0.0095	0.2268	0.5192
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0693	0.1211
Brugia malayi	Bm-MIF-1, identical	0.0167	0.4367	1
Brugia malayi	Thioredoxin reductase	0.0044	0.0755	0.1729
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0261	0.13
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0261	0.0177
Echinococcus multilocularis	snurportin 1	0.0358	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0965	0.0965
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0523	0.0523
Brugia malayi	beta-lactamase family protein	0.0042	0.0693	0.1586
Loa Loa (eye worm)	thioredoxin reductase	0.0044	0.0755	0.0755
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0044	0.0755	0.0094
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.1167	0.2672
Schistosoma mansoni	hypothetical protein	0.0197	0.5262	0.5262
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0693	0.1211
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.01	0.2415	0.8393
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0066	0.139	0.139
Brugia malayi	glutathione reductase	0.0044	0.0755	0.1729
Onchocerca volvulus		0.0042	0.0693	0.5
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0045	0.0772	0.0772
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0693	0.0693
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0693	0.8902
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.01	0.2415	0.2592
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0693	0.1211
Schistosoma mansoni	ran	0.0025	0.0187	0.0187
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0693	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0447	0.0447
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0693	0.0693
Schistosoma mansoni	importin beta-1	0.0034	0.0447	0.0447
Trypanosoma cruzi	trypanothione reductase, putative	0.0044	0.0755	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0693	0.0693
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0112	0.2744	0.3088
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0261	0.0177
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0693	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1167	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0693	0.0693
Onchocerca volvulus		0.0042	0.0693	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0693	0.0693
Loa Loa (eye worm)	jmjC domain-containing protein	0.0066	0.139	0.139
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.01	0.2415	0.2592
Echinococcus multilocularis	geminin	0.0197	0.5262	0.5262
Echinococcus granulosus	importin subunit beta 1	0.0034	0.0447	0.0447
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0025	0.0187	0.0187
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0965	0.0965
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0112	0.2744	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0523	0.0804
Entamoeba histolytica	hypothetical protein	0.0036	0.0523	0.0804
Echinococcus granulosus	geminin	0.0197	0.5262	0.5262
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0025	0.0187	0.0187
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0025	0.0187	0.0427
Echinococcus granulosus	thioredoxin glutathione reductase	0.0045	0.0772	0.0772
Plasmodium falciparum	macrophage migration inhibitory factor	0.0167	0.4367	1
Schistosoma mansoni	hypothetical protein	0.0358	1	1
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0261	0.0177
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0965	0.0965
Plasmodium falciparum	importin beta, putative	0.0034	0.0447	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0693	0.0693
Schistosoma mansoni	hypothetical protein	0.0197	0.5262	0.5262
Trypanosoma brucei	trypanothione reductase	0.0044	0.0755	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0693	0.1211
Schistosoma mansoni	jumonji domain containing protein	0.0066	0.139	0.139
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0693	0.0693
Toxoplasma gondii	thioredoxin reductase	0.0044	0.0755	0.136
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0523	0.0523
Plasmodium vivax	glutathione reductase, putative	0.0044	0.0755	0.136
Brugia malayi	jmjC domain containing protein	0.0066	0.139	0.3183
Plasmodium vivax	importin-beta 2, putative	0.0034	0.0447	0.0623
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0965	0.0965
Trichomonas vaginalis	esterase, putative	0.0042	0.0693	0.1211
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0965	0.0965
Loa Loa (eye worm)	glutathione reductase	0.0044	0.0755	0.0755
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0268	0.7336	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0693	0.0693
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.01	0.2415	0.2592
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0965	0.0965
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0693	0.8902
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0965	0.0965
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0965	0.2209
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0066	0.139	0.139
Plasmodium vivax	thioredoxin reductase, putative	0.0044	0.0755	0.136
Brugia malayi	beta-lactamase	0.0042	0.0693	0.1586
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0447	0.4584
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.0167	0.4367	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.0447	0.0623
Schistosoma mansoni	hypothetical protein	0.0036	0.0523	0.0523
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.0447	0.0447
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0358	1	1
Plasmodium falciparum	glutathione reductase	0.0044	0.0755	0.136
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0693	0.8902
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0066	0.139	0.139
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0693	0.1211
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0112	0.2744	0.3088
Schistosoma mansoni	hypothetical protein	0.004	0.0627	0.0627
Entamoeba histolytica	hypothetical protein	0.0027	0.0261	0.0177
Echinococcus multilocularis	lysine specific demethylase 5A	0.0066	0.139	0.139
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.1167	0.2672
Brugia malayi	beta-lactamase family protein	0.0042	0.0693	0.1586
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0523	0.0523
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0693	0.5
Brugia malayi	jmjC domain containing protein	0.0066	0.139	0.3183
Toxoplasma gondii	ABC1 family protein	0.0042	0.0693	0.1211
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0025	0.0187	0.0187
Giardia lamblia	Macrophage migration inhibitory factor	0.0167	0.4367	1
Mycobacterium tuberculosis	Probable reductase	0.01	0.2415	0.2592
Brugia malayi	hypothetical protein	0.0036	0.0523	0.1197
Leishmania major	hypothetical protein, conserved	0.0042	0.0693	0.1211
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0627	0.1435
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0693	0.5
Brugia malayi	Importin beta-1 subunit	0.0034	0.0447	0.1024
Mycobacterium tuberculosis	Probable oxidoreductase	0.0112	0.2744	0.3088

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 658573