Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0025 | 0.0466 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0025 | 0.0466 | 0.1501 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0364 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0025 | 0.0466 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0025 | 0.0466 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0466 | 0.1501 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0025 | 0.0466 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0025 | 0.0466 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0025 | 0.0466 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0.0466 | 0.1501 |
Onchocerca volvulus | 0.0025 | 0.0466 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0025 | 0.0466 | 0.1501 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.3103 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0025 | 0.0466 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0.0466 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0025 | 0.0466 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.3103 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0364 | 1 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0.0466 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0025 | 0.0466 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0025 | 0.0466 | 0.5 |
Onchocerca volvulus | 0.0025 | 0.0466 | 0.5 | |
Leishmania major | oxidoreductase-like protein | 0.0025 | 0.0466 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0364 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0364 | 1 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0.0466 | 0.1501 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0364 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0364 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0364 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0364 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0025 | 0.0466 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0025 | 0.0466 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0025 | 0.0466 | 0.1501 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.3103 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0025 | 0.0466 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.