Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | aldehyde dehydrogenase family, putative | 0.0025 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0025 | 1 | 0.5 |
Echinococcus granulosus | Fatty aldehyde dehydrogenase | 0.0025 | 1 | 1 |
Trypanosoma cruzi | aldehyde dehydrogenase family, putative | 0.0025 | 1 | 0.5 |
Onchocerca volvulus | Aldehyde dehydrogenase homolog | 0.0025 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase (NAD+) dependent | 0.0025 | 1 | 0.5 |
Echinococcus multilocularis | Fatty aldehyde dehydrogenase | 0.0025 | 1 | 1 |
Trichomonas vaginalis | succinate semialdehyde dehydrogenase, putative | 0.0025 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase (NAD+) dependent | 0.0025 | 1 | 0.5 |
Entamoeba histolytica | aldehyde dehydrogenase 1, putative | 0.0025 | 1 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase family 3 member B1 | 0.0025 | 1 | 1 |
Loa Loa (eye worm) | aldehyde dehydrogenase 4 | 0.0025 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase family 3 member B1 | 0.0025 | 1 | 1 |
Trypanosoma brucei | aldehyde dehydrogenase family, putative | 0.0025 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT | 0.0025 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.