Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.003 | 0.0662 | 0.0877 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.003 | 0.0662 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0676 | 0.0676 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.003 | 0.0662 | 0.0265 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0676 | 0.0676 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0676 | 0.0064 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0013 | 0.0011 | 0.0011 |
Leishmania major | trypanothione reductase | 0.0086 | 0.2804 | 0.322 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0197 | 0.7004 | 0.8868 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.003 | 0.0662 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0086 | 0.2804 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0087 | 0.2823 | 0.742 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.003 | 0.0662 | 0.0265 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0676 | 0.1775 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0086 | 0.2804 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0125 | 0.428 | 0.5674 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0025 | 0.0469 | 0.0543 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0211 | 0.7542 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0013 | 0 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0676 | 0.0064 |
Toxoplasma gondii | thioredoxin reductase | 0.0086 | 0.2804 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.003 | 0.0662 | 0.0261 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0216 | 0.772 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Plasmodium vivax | glutathione reductase, putative | 0.0086 | 0.2804 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0197 | 0.7004 | 0.8868 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0013 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | glutathione reductase | 0.0086 | 0.2804 | 0.3718 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0086 | 0.2804 | 0.3168 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0086 | 0.2804 | 0.322 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.003 | 0.0662 | 0.1739 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.003 | 0.0662 | 0.0265 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0013 | 0.0011 | 0.0015 |
Trypanosoma brucei | trypanothione reductase | 0.0086 | 0.2804 | 0.3035 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.003 | 0.0662 | 0.5 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0025 | 0.0469 | 0.1233 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0022 | 0.036 | 0.0478 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.003 | 0.0662 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0197 | 0.7004 | 0.8868 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.003 | 0.0662 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.003 | 0.0662 | 0.0765 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0113 | 0.3805 | 0.5046 |
Brugia malayi | Pre-SET motif family protein | 0.0211 | 0.7542 | 1 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0013 | 0.0011 | 0.003 |
Entamoeba histolytica | hypothetical protein | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0197 | 0.7004 | 0.8868 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0113 | 0.3805 | 0.5046 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0219 | 0.7838 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0216 | 0.772 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0219 | 0.7838 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0219 | 0.7838 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0216 | 0.772 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0125 | 0.428 | 0.428 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Plasmodium falciparum | thioredoxin reductase | 0.0086 | 0.2804 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0676 | 0.1775 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0113 | 0.3805 | 0.5046 |
Brugia malayi | Thioredoxin reductase | 0.0086 | 0.2804 | 0.3718 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0113 | 0.3805 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0197 | 0.7004 | 0.8868 |
Onchocerca volvulus | 0.0241 | 0.8649 | 1 | |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0113 | 0.3805 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0216 | 0.772 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0241 | 0.8649 | 1 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0025 | 0.0469 | 0.1233 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0676 | 0.1775 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0022 | 0.036 | 0.0478 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0.0662 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0633 | 0.1664 |
Brugia malayi | glutathione reductase | 0.0086 | 0.2804 | 0.3718 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0676 | 0.0676 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0219 | 0.7838 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0086 | 0.2804 | 0.3718 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0087 | 0.2823 | 0.742 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.003 | 0.0662 | 0.0662 |
Treponema pallidum | NADH oxidase | 0.003 | 0.0662 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0197 | 0.7004 | 0.8868 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0662 | 0.0265 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.003 | 0.0662 | 0.1739 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0.0662 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0676 | 0.0896 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0125 | 0.428 | 0.5674 |
Trichomonas vaginalis | mercuric reductase, putative | 0.003 | 0.0662 | 0.0765 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0676 | 0.0676 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0013 | 0.0011 | 0.003 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0676 | 0.0896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.