Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0029 | 0.0073 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0193 | 0.2464 | 0.8868 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0029 | 0.0073 | 0.0263 |
Plasmodium vivax | SET domain protein, putative | 0.006 | 0.0526 | 0.561 |
Plasmodium falciparum | thioredoxin reductase | 0.0084 | 0.088 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0029 | 0.0073 | 0.0261 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0213 | 0.2757 | 0.4153 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0211 | 0.2734 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0029 | 0.0073 | 0.0073 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0193 | 0.2464 | 0.8868 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0147 | 0.1798 | 0.6469 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.006 | 0.0526 | 0.0456 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0213 | 0.2757 | 0.4238 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Treponema pallidum | NADH oxidase | 0.0029 | 0.0073 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.042 | 0.579 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.006 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0084 | 0.088 | 0.0674 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.006 | 0.0526 | 0.0526 |
Brugia malayi | Pre-SET motif family protein | 0.006 | 0.0526 | 0.0793 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0213 | 0.2757 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0058 | 0.0493 | 0.0493 |
Trypanosoma brucei | trypanothione reductase | 0.0084 | 0.088 | 0.3035 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0213 | 0.2757 | 0.4153 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Onchocerca volvulus | 0.0213 | 0.2757 | 0.365 | |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0213 | 0.2757 | 0.4153 |
Brugia malayi | glutathione reductase | 0.0084 | 0.088 | 0.1413 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.006 | 0.0526 | 0.561 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0029 | 0.0073 | 0.0109 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0213 | 0.2757 | 0.4695 |
Leishmania major | hypothetical protein, conserved | 0.0211 | 0.2734 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0084 | 0.088 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0213 | 0.2757 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0084 | 0.088 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0029 | 0.0073 | 0.0263 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0066 | 0.0604 | 0.1996 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0707 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0084 | 0.088 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.006 | 0.0526 | 0.0456 |
Brugia malayi | Thioredoxin reductase | 0.0084 | 0.088 | 0.1413 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Plasmodium vivax | glutathione reductase, putative | 0.0084 | 0.088 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0029 | 0.0073 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0213 | 0.2757 | 0.4153 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0213 | 0.2757 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0193 | 0.2464 | 0.8868 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0214 | 0.2779 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0066 | 0.0604 | 0.2208 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0211 | 0.2734 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0214 | 0.2779 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0066 | 0.0604 | 0.0909 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0213 | 0.2757 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0066 | 0.0604 | 0.2208 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0029 | 0.0073 | 0.0265 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0084 | 0.088 | 0.3168 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0193 | 0.2464 | 0.8868 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0029 | 0.0073 | 0.0109 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0029 | 0.0073 | 0.0265 |
Trichomonas vaginalis | set domain proteins, putative | 0.0478 | 0.6639 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.006 | 0.0526 | 0.0456 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0066 | 0.0604 | 0.2208 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0214 | 0.2779 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0707 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0193 | 0.2464 | 0.8868 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0213 | 0.2757 | 0.4153 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0066 | 0.0604 | 0.0909 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0213 | 0.2757 | 0.4153 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0214 | 0.2779 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0084 | 0.088 | 0.0674 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.006 | 0.0526 | 0.0456 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0029 | 0.0073 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0029 | 0.0073 | 0.0263 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.042 | 0.579 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0085 | 0.0888 | 0.0888 |
Leishmania major | trypanothione reductase | 0.0084 | 0.088 | 0.322 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0084 | 0.088 | 0.322 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Onchocerca volvulus | 0.0478 | 0.6639 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0211 | 0.2734 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0029 | 0.0073 | 0.0265 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0085 | 0.0888 | 0.0888 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0193 | 0.2464 | 0.8868 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0029 | 0.0073 | 0.0073 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.006 | 0.0526 | 0.0526 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0029 | 0.0073 | 0.0265 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.