Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | methionyl-tRNA synthetase | 0.0228 | 0.7169 | 0.5 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0197 | 0.5811 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0228 | 0.7169 | 0.5 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0195 | 0.5759 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 1 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0228 | 0.7169 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0195 | 0.5759 | 0.5 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0063 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.3958 | 0.5 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0195 | 0.5759 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0293 | 1 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0195 | 0.5759 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.3958 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.