Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0301 | 1 | 1 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1137 | 0.1137 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0228 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0415 | 0.1788 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0154 | 0.6746 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.1616 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0415 | 0.0415 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0116 | 0.3496 | 0.3496 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 0.1616 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1137 | 0.3885 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0154 | 0.0154 |
Echinococcus granulosus | adam | 0.0095 | 0.2769 | 0.2769 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.1616 | 1 |
Brugia malayi | hypothetical protein | 0.0095 | 0.2769 | 0.9456 |
Brugia malayi | Disintegrin family protein | 0.01 | 0.2928 | 1 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0042 | 0.0891 | 0.3044 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0228 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0596 | 0.2034 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0116 | 0.3496 | 0.3496 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0415 | 1 |
Loa Loa (eye worm) | reprolysin | 0.0116 | 0.3496 | 0.3496 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0891 | 0.0891 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0596 | 0.0596 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0228 | 0.1411 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0154 | 0.3703 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.1616 | 1 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Brugia malayi | ADAMTS-like protease | 0.0042 | 0.0891 | 0.3044 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.2242 | 0.7657 |
Brugia malayi | angiogenesis inhibito | 0.0042 | 0.0891 | 0.3044 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0116 | 0.3496 | 0.3496 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0154 | 0.0154 |
Brugia malayi | Reprolysin | 0.0076 | 0.2086 | 0.7125 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.01 | 0.2928 | 0.2928 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0891 | 0.0891 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0154 | 0.0525 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0072 | 0.1966 | 0.1966 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0228 | 1 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0415 | 1 |
Echinococcus granulosus | adam 17 protease | 0.004 | 0.0835 | 0.0835 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0154 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0057 | 0.1426 | 0.8824 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.172 | 0.172 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1966 | 0.1966 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0154 | 0.0952 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0415 | 0.1419 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.1616 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0301 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Schistosoma mansoni | dihydroceramide desaturase | 0.01 | 0.2928 | 0.2928 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0228 | 0.1411 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1137 | 0.1137 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0072 | 0.1966 | 0.1966 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1137 | 0.3885 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0415 | 0.0415 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0415 | 0.1788 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0415 | 0.0415 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Loa Loa (eye worm) | disintegrin family protein | 0.0059 | 0.1518 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0474 | 0.0474 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0415 | 1 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0095 | 0.2769 | 0.2769 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0116 | 0.3496 | 0.3496 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0154 | 0.6746 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.1616 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0415 | 0.0415 |
Schistosoma mansoni | ran | 0.0021 | 0.0154 | 0.0154 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.01 | 0.2928 | 0.2928 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0154 | 0.0952 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Echinococcus multilocularis | adam | 0.0095 | 0.2769 | 0.2769 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0228 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0154 | 0.0154 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.1616 | 1 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0596 | 0.0596 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0154 | 0.3703 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0154 | 0.0952 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0049 | 0.1147 | 0.7098 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.1616 | 1 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0154 | 0.3703 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.