Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate hydrolase (prostate-specific membrane antigen) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0802 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidase | 0.0064 | 0.0619 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.027 | 0.3237 | 1 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0064 | 0.0619 | 0.0203 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0044 | 0.0373 | 0.0076 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0064 | 0.0619 | 0.0255 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0107 | 0.1168 | 0.0776 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0064 | 0.0619 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.027 | 0.3237 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1932 | 0.1683 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0064 | 0.0619 | 0.0255 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.027 | 0.3237 | 0.2975 |
Brugia malayi | prolyl oligopeptidase family protein | 0.027 | 0.3237 | 0.2975 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0064 | 0.0619 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0064 | 0.0619 | 0.0255 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0064 | 0.0619 | 0.0255 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.027 | 0.3237 | 0.2937 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0619 | 0.033 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0064 | 0.0619 | 0.5 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0064 | 0.0619 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0064 | 0.0619 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0619 | 0.033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0619 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0064 | 0.0619 | 0.033 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0802 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.027 | 0.3237 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0802 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.027 | 0.3237 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0163 | 0.1881 | 0.1566 |
Plasmodium vivax | hypothetical protein, conserved | 0.0064 | 0.0619 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0802 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0064 | 0.0619 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0064 | 0.0619 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.243 | 0.2196 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0064 | 0.0619 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0064 | 0.0619 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.027 | 0.3237 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0064 | 0.0619 | 0.5 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0064 | 0.0619 | 0.0255 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0064 | 0.0619 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0064 | 0.0619 | 0.0255 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0064 | 0.0619 | 0.0203 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0064 | 0.0619 | 1 |
Brugia malayi | hypothetical protein | 0.0206 | 0.243 | 0.2136 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1743 | 0.1489 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1218 | 0.0947 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0064 | 0.0619 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0064 | 0.0619 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0064 | 0.0619 | 1 |
Plasmodium falciparum | peptidase, putative | 0.0064 | 0.0619 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0619 | 0.033 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.027 | 0.3237 | 0.2975 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.027 | 0.3237 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0802 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0064 | 0.0619 | 0.0203 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.34 uM | Concentration required for inhibition of 50% of the cleavage of para-nitroanilide from MeO-Suc-Arg-Pro-Tyr-pNA.HCl by Prostate specific antigen PSA | ChEMBL. | No reference |
IC50 (functional) | = 1.34 uM | Concentration required for inhibition of 50% of the cleavage of para-nitroanilide from MeO-Suc-Arg-Pro-Tyr-pNA.HCl by Prostate specific antigen PSA | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.