Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0036 | 0.3118 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1906 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0036 | 0.0031 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0104 | 0.0069 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0005 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0036 | 0.3118 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0005 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0104 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0104 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0036 | 0.3118 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0036 | 0.0031 |
Schistosoma mansoni | protein kinase | 0.1906 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0104 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0788 | 0.0691 |
Onchocerca volvulus | 0.0023 | 0.0036 | 0.5 | |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0104 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0036 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.1903 | 0.9985 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0104 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0005 | 0.0593 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0036 | 0.3118 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0788 | 0.0691 |
Loa Loa (eye worm) | hypothetical protein | 0.0574 | 0.2951 | 0.2952 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0104 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0577 | 0.2966 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1906 | 1 | 1 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0577 | 0.2966 | 0.2967 |
Schistosoma mansoni | protein kinase | 0.1906 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0036 | 0.3118 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0036 | 0.4266 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0788 | 0.0691 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0104 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0084 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0104 | 0.0099 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0036 | 0.4266 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0084 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0577 | 0.2966 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0104 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.0788 | 0.0691 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0036 | 0.3118 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0005 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0036 | 0.3118 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0104 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0036 | 0.3118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.