Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0238 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0138 | 0.3698 | 0.6086 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0138 | 0.3698 | 0.6086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Onchocerca volvulus | 0.0138 | 0.3698 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0138 | 0.3698 | 0.6086 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.3698 | 0.5599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.0672 | 0.1107 |
Leishmania major | cathepsin L-like protease | 0.0138 | 0.3698 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0138 | 0.3698 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0138 | 0.3698 | 0.6086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.6076 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.009 | 0.0672 | 0.1818 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0138 | 0.3698 | 0.6086 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0176 | 0.6076 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0138 | 0.3698 | 0.6086 |
Onchocerca volvulus | 0.0138 | 0.3698 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0138 | 0.3698 | 0.6086 |
Onchocerca volvulus | 0.0138 | 0.3698 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0176 | 0.6076 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0138 | 0.3698 | 0.6086 |
Plasmodium falciparum | dipeptidyl aminopeptidase 3 | 0.011 | 0.1917 | 0.1917 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0238 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0138 | 0.3698 | 0.3698 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0138 | 0.3698 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0238 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Leishmania major | cathepsin L-like protease | 0.0138 | 0.3698 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0238 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0176 | 0.6076 | 0.6076 |
Brugia malayi | Cathepsin L-like precursor | 0.0138 | 0.3698 | 0.6086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0138 | 0.3698 | 0.6086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.0672 | 0.133 |
Brugia malayi | Cathepsin L-like precursor | 0.0138 | 0.3698 | 0.6086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Onchocerca volvulus | 0.0138 | 0.3698 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.0672 | 0.1107 |
Leishmania major | cathepsin L-like protease | 0.0138 | 0.3698 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0138 | 0.3698 | 0.6086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0176 | 0.6076 | 0.6076 |
Brugia malayi | Cathepsin L-like precursor | 0.0138 | 0.3698 | 0.6086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.011 | 0.1917 | 0.1917 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Plasmodium vivax | vivapain-2 | 0.0138 | 0.3698 | 0.3698 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0138 | 0.3698 | 0.5599 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0138 | 0.3698 | 0.6086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Leishmania major | cathepsin L-like protease | 0.0138 | 0.3698 | 0.5 |
Toxoplasma gondii | cathepsin CPL | 0.0138 | 0.3698 | 0.2204 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.009 | 0.0672 | 0.1107 |
Toxoplasma gondii | cathepsin CPC1 | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0138 | 0.3698 | 0.5599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.0672 | 0.133 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0238 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0138 | 0.3698 | 0.3698 |
Loa Loa (eye worm) | ctsf protein | 0.0138 | 0.3698 | 0.5599 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0138 | 0.3698 | 0.6086 |
Loa Loa (eye worm) | fibroinase | 0.0138 | 0.3698 | 0.5599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Onchocerca volvulus | 0.0138 | 0.3698 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0138 | 0.3698 | 0.3698 |
Brugia malayi | Cathepsin L-like precursor | 0.0138 | 0.3698 | 0.6086 |
Onchocerca volvulus | Cathepsin F homolog | 0.0138 | 0.3698 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0138 | 0.3698 | 0.6086 |
Leishmania major | cathepsin L-like protease | 0.0138 | 0.3698 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0176 | 0.6076 | 0.6076 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0138 | 0.3698 | 0.6086 |
Leishmania major | cathepsin L-like protease | 0.0138 | 0.3698 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0138 | 0.3698 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0138 | 0.3698 | 0.6086 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0138 | 0.3698 | 0.3698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0138 | 0.3698 | 0.3698 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.009 | 0.0672 | 0.1107 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0176 | 0.6076 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0176 | 0.6076 | 0.6076 |
Leishmania major | cysteine peptidase A (CPA) | 0.0138 | 0.3698 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0138 | 0.3698 | 0.6086 |
Entamoeba histolytica | cysteine protease, putative | 0.0138 | 0.3698 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0138 | 0.3698 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0138 | 0.3698 | 0.5599 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0238 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0138 | 0.3698 | 0.7312 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.016 | 0.5057 | 1 |
Echinococcus granulosus | cathepsin b | 0.0176 | 0.6076 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.009 | 0.0672 | 0.0672 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0138 | 0.3698 | 0.3698 |
Leishmania major | cathepsin L-like protease | 0.0138 | 0.3698 | 0.5 |
Onchocerca volvulus | 0.0138 | 0.3698 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.009 | 0.0672 | 0.1107 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.009 | 0.0672 | 0.1107 |
Onchocerca volvulus | Cathepsin L homolog | 0.0138 | 0.3698 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0176 | 0.6076 | 1 |
Onchocerca volvulus | 0.0138 | 0.3698 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0138 | 0.3698 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0138 | 0.3698 | 0.6086 |
Echinococcus multilocularis | cathepsin b | 0.0176 | 0.6076 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Estrogenic effect (functional) | = 0 % | Estrogenicity in rats following 3 x 1 mg s.c. over 72h. | ChEMBL. | 2754694 |
Inhibition (functional) | = 0 % | Inhibition of E2 effects in rats by 1 mg s.c. | ChEMBL. | 2754694 |
RBA (binding) | = 0.12 g | Relative binding against estrogen receptor of rat uterine cytosol by [2-4-3H] estradiol. | ChEMBL. | 2754694 |
RBA (binding) | = 0.12 g | Relative binding against estrogen receptor of rat uterine cytosol by [2-4-3H] estradiol. | ChEMBL. | 2754694 |
Uterine weight (functional) | = 13.7 g | Uterotrophic effects in rats following 3 x 1 mg s.c. over 72h. | ChEMBL. | 2754694 |
Uterine weight (functional) | = 47.4 g | Anti-uterotrophic effects in rats following 3 x 1 mg s.c. over 72h. | ChEMBL. | 2754694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.