Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidine kinase | 0.0242 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0113 | 0.1286 | 0.1286 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0113 | 0.1286 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0113 | 0.1286 | 1 |
Schistosoma mansoni | thymidine kinase | 0.0242 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0113 | 0.1286 | 0.1286 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0113 | 0.1286 | 0.1286 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | thymidine kinase | 0.0242 | 1 | 1 |
Echinococcus multilocularis | thymidine kinase | 0.0242 | 1 | 1 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0242 | 1 | 1 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0242 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0113 | 0.1286 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0113 | 0.1286 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0113 | 0.1286 | 0.1286 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0113 | 0.1286 | 0.1286 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0113 | 0.1286 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0113 | 0.1286 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0113 | 0.1286 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0113 | 0.1286 | 0.1286 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0113 | 0.1286 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0113 | 0.1286 | 0.1286 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0113 | 0.1286 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0113 | 0.1286 | 0.1286 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Inhibition of [3H]hypoxanthine uptake into Plasmodium falciparum 3D7 at 120 uM | ChEMBL. | 17149876 | |
Activity (functional) | Antimalarial activity against Plasmodium falciparum 3D7 at 120 uM | ChEMBL. | 17149876 | |
Activity (functional) | 0 | Inhibition of [3H]hypoxanthine uptake into Plasmodium falciparum 3D7 at 120 uM | ChEMBL. | 17149876 |
Activity (functional) | 0 | Antimalarial activity against Plasmodium falciparum 3D7 at 120 uM | ChEMBL. | 17149876 |
ID50 (functional) | = 0.0000106 M | In vitro inhibitory concentration required for 50% inhibition of L1210 cell growth | ChEMBL. | 7205884 |
ID50 (functional) | = 0.0000106 M | In vitro inhibitory concentration required for 50% inhibition of L1210 cell growth | ChEMBL. | 7205884 |
Km(app) (binding) | Inhibition of human HGPRT at pH 7.4 | ChEMBL. | 17149876 | |
Km(app) (binding) | 0 | Inhibition of human HGPRT at pH 7.4 | ChEMBL. | 17149876 |
Km(app) (binding) | = 82 uM | Inhibition of Plasmodium falciparum HGXPRT at pH 7.4 | ChEMBL. | 17149876 |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
8 literature references were collected for this gene.