Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0103 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0036 | 0.3118 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0036 | 0.3118 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0005 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0036 | 0.3118 |
Echinococcus granulosus | geminin | 0.0165 | 0.0782 | 0.0686 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0103 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0103 | 0.0099 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0036 | 0.4266 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0579 | 0.2966 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0084 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0084 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0103 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0036 | 0.4266 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0782 | 0.0686 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0036 | 0.3118 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1912 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0579 | 0.2966 | 1 |
Schistosoma mansoni | protein kinase | 0.1912 | 1 | 1 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0579 | 0.2966 | 0.2967 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0103 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0576 | 0.2951 | 0.2952 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0782 | 0.0686 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0103 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0036 | 0.3118 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0005 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0036 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.1909 | 0.9985 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0103 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0782 | 0.0686 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0103 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.0036 | 0.5 | |
Schistosoma mansoni | protein kinase | 0.1912 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0036 | 0.0031 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0036 | 0.3118 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0036 | 0.0031 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0103 | 0.0068 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0036 | 0.3118 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1912 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0103 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0005 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0103 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0005 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0036 | 0.3118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.