Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | hypothetical protein | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0167 | 0.2759 | 0.2625 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.428 | 1 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0188 | 0.3208 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.3208 | 0.3082 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.2259 | 0.6863 |
Onchocerca volvulus | 0.0103 | 0.1376 | 1 | |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0188 | 0.3208 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0103 | 0.1376 | 0.3943 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0188 | 0.3208 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0103 | 0.1376 | 0.1215 |
Brugia malayi | Muscleblind-like protein | 0.0319 | 0.601 | 0.5936 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0167 | 0.2759 | 0.2625 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0167 | 0.2759 | 0.2625 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0188 | 0.3208 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0188 | 0.3208 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0319 | 0.601 | 0.5936 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0188 | 0.3208 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0188 | 0.3208 | 1 |
Mycobacterium ulcerans | integral membrane protein | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.2259 | 0.6863 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0504 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0319 | 0.601 | 0.5936 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.601 | 0.5936 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.601 | 0.5936 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0504 | 1 | 1 |
Plasmodium falciparum | protease, putative | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.1376 | 0.3943 |
Toxoplasma gondii | hypothetical protein | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0167 | 0.2759 | 0.2625 |
Chlamydia trachomatis | hypothetical protein | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 1 | 1 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0188 | 0.3208 | 0.3082 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0167 | 0.2759 | 0.2625 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0 | 0.5 |
Plasmodium vivax | protease, putative | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0188 | 0.3208 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0319 | 0.601 | 0.5936 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0039 | 0 | 0.5 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0188 | 0.3208 | 0.3082 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0188 | 0.3208 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0188 | 0.3208 | 0.3082 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.