TDR Targets

Basic information

Technical information

TDR Targets ID: 676804
Name: STK128270
MW: 434.441 | Formula: C24H22N2O6
H donors: 2 H acceptors: 3 LogP: 3.29 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(NC(=O)c2ccccc2)c(cc1NC(=O)c1ccc(cc1)OC(=O)C)OC
InChi: 1S/C24H22N2O6/c1-15(27)32-18-11-9-17(10-12-18)24(29)26-20-14-21(30-2)19(13-22(20)31-3)25-23(28)16-7-5-4-6-8-16/h4-14H,1-3H3,(H,25,28)(H,26,29)
InChiKey: IQZTXRYNDATLQC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tar DNA binding protein	0.0199	0.2251	0.2211
Onchocerca volvulus	Deterin homolog	0.0224	0.2556	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0204	0.0374
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0051	0.0201
Brugia malayi	RNA recognition motif domain containing protein	0.0199	0.2251	0.8806
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0051	0.0201
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2251	0.5399
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0204	0.0153
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0051	0.0201
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0929	0.2154
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0204	0.0797
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0414	0.5
Brugia malayi	hypothetical protein	0.0026	0.0116	0.0452
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.1099	0.4299
Brugia malayi	MAP kinase sur-1	0.0051	0.0414	0.162
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0204	0.0608
Trypanosoma brucei	protein kinase, putative	0.0051	0.0414	1
Brugia malayi	steroid hormone receptor	0.0021	0.0051	0.0201
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0224	0.2556	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0414	0.089
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0224	0.2556	0.6148
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2251	0.5399
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0051	0.0201
Brugia malayi	ecdysteroid receptor	0.0021	0.0051	0.0201
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0414	1
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0051	0.0201
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0224	0.2556	0.6148
Loa Loa (eye worm)	hypothetical protein	0.0224	0.2556	1
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0414	0.0365
Onchocerca volvulus		0.0224	0.2556	1
Brugia malayi	RNA binding protein	0.0199	0.2251	0.8806
Schistosoma mansoni	hypothetical protein	0.0351	0.4126	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0414	1
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0224	0.2556	1
Echinococcus multilocularis	geminin	0.0351	0.4126	0.4095
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0414	0.5
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0204	0.0153
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0414	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0204	0.0153
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0116	0.5
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1099	0.4182
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2251	0.5399
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0051	0.0201
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0929	0.3504
Schistosoma mansoni	hypothetical protein	0.0351	0.4126	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0051	0.0201
Schistosoma mansoni	hypothetical protein	0.0072	0.0685	0.1554
Schistosoma mansoni	hypothetical protein	0.0034	0.0204	0.0374
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0224	0.2556	0.2518
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0929	0.2154
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0051	0.0201
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0685	0.2678
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0051	0.0201
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0414	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0929	0.2154
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0051	0.0201
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0204	0.0374
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0929	0.0882
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0051	0.0201
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0414	0.5
Schistosoma mansoni	hypothetical protein	0.0034	0.0204	0.0374
Echinococcus granulosus	tar DNA binding protein	0.0199	0.2251	0.5399
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0116	0.0256
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0204	0.0797
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0051	0.0201
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0051	0.0201
Echinococcus granulosus	inhibitor of apoptosis protein	0.0224	0.2556	0.6148
Brugia malayi	nuclear hormone receptor	0.0021	0.0051	0.0201
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.1099	0.4182
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0414	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0204	0.0608
Schistosoma mansoni	hypothetical protein	0.0034	0.0204	0.0374
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.1099	0.4299
Brugia malayi	TAR-binding protein	0.0199	0.2251	0.8806
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0224	0.2556	0.2518
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0051	0.0201
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0051	0.0201
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0414	1
Schistosoma mansoni	inhibitor of apoptosis protein	0.0224	0.2556	0.6148
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0414	0.0365
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0414	0.089
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0929	0.2154
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0051	0.0201
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0414	1
Loa Loa (eye worm)	hypothetical protein	0.0224	0.2556	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0116	0.5
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0414	0.1448
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0929	0.2154
Echinococcus granulosus	geminin	0.0351	0.4126	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0116	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0414	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0414	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0929	0.0882
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2251	0.5399
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0199	0.2251	0.8782
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2251	0.5399
Schistosoma mansoni	hypothetical protein	0.0034	0.0204	0.0374
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0929	0.3634
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0414	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0051	0.0201
Loa Loa (eye worm)	TAR-binding protein	0.0199	0.2251	0.8782
Schistosoma mansoni	hypothetical protein	0.0224	0.2556	0.6148
Echinococcus granulosus	GPCR family 2	0.0034	0.0204	0.0374
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0414	0.089
Loa Loa (eye worm)	RNA binding protein	0.0199	0.2251	0.8782
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0685	0.2528

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 676804