Detailed information for compound 677190

Basic information

Technical information
  • TDR Targets ID: 677190
  • Name: N-(2-fluorophenyl)-4-morpholin-4-ylquinazolin -2-amine
  • MW: 324.352 | Formula: C18H17FN4O
  • H donors: 1 H acceptors: 2 LogP: 3.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1Nc1nc(N2CCOCC2)c2c(n1)cccc2
  • InChi: 1S/C18H17FN4O/c19-14-6-2-4-8-16(14)21-18-20-15-7-3-1-5-13(15)17(22-18)23-9-11-24-12-10-23/h1-8H,9-12H2,(H,20,21,22)
  • InChiKey: KHKLCXKFJINPPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-fluorophenyl)-4-morpholino-quinazolin-2-amine
  • N-(2-fluorophenyl)-4-morpholino-2-quinazolinamine
  • (2-fluorophenyl)-(4-morpholinoquinazolin-2-yl)amine
  • N-(2-fluorophenyl)-4-morpholin-4-yl-quinazolin-2-amine
  • STOCK3S-00241
  • ZINC00356479
  • Neuro1_000464
  • Oprea1_840294
  • Oprea1_404977

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0212 0.1102 0.1102
Echinococcus multilocularis receptor type guanylyl cyclase 0.0109 0.0452 0.0452
Loa Loa (eye worm) glutaminase 2 0.0275 0.1495 0.6143
Schistosoma mansoni hypothetical protein 0.0212 0.1102 0.3537
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0508 0.296 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0109 0.0452 0.1857
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0151 0.051
Schistosoma mansoni tyrosine kinase 0.0109 0.0452 0.1449
Echinococcus granulosus glutamate receptor 2 0.0533 0.3117 0.7258
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0508 0.296 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0151 0.0351
Echinococcus multilocularis nmda type glutamate receptor 0.072 0.4295 0.4295
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.2681 0.2681
Schistosoma mansoni ATP-binding cassette transporter 0.0424 0.2433 0.7804
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0151 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0212 0.1102 0.1102
Brugia malayi hypoxia-induced factor 1 0.0151 0.0719 0.2954
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0082 0.0338
Onchocerca volvulus Huntingtin homolog 0.0123 0.0541 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0533 0.3117 0.7258
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0001 0.0021
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0109 0.0452 0.1857
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0001 0.0001
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0001 0.0001
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0508 0.296 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0055 0.0178
Chlamydia trachomatis glutamine binding protein 0.0508 0.296 0.5
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0109 0.0452 0.5032
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.2681 0.6241
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0055 0.0228
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0109 0.0452 0.0452
Onchocerca volvulus 0.0109 0.0452 0.5032
Schistosoma mansoni metabotropic glutamate receptor 0.0109 0.0452 0.1449
Loa Loa (eye worm) hypothetical protein 0.0109 0.0452 0.1857
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0001 0.0006
Brugia malayi PAS domain containing protein 0.0049 0.0075 0.0307
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0212 0.1102 0.1102
Schistosoma mansoni alpha-glucosidase 0.014 0.0651 0.2088
Brugia malayi Guanylyl cyclase protein 23 0.0109 0.0452 0.1857
Loa Loa (eye worm) hypothetical protein 0.0109 0.0452 0.1857
Echinococcus granulosus glutamate receptor subunit protein glur 0.0212 0.1102 0.2567
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0533 0.3117 0.7258
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0151 0.051
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0001 0.0002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.072 0.4295 0.4295
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0055 0.0055
Echinococcus granulosus neuropeptide s receptor 0.0463 0.2681 0.6241
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0001 0.0003
Loa Loa (eye worm) glutamate receptor 1 0.0424 0.2433 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0212 0.1102 0.2567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0055 0.0055
Onchocerca volvulus 0.0109 0.0452 0.5032
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0719 0.2954
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0424 0.2433 0.2433
Entamoeba histolytica hypothetical protein 0.0109 0.0452 1
Schistosoma mansoni glutamate receptor NMDA 0.0533 0.3117 1
Brugia malayi Receptor family ligand binding region containing protein 0.0109 0.0452 0.1857
Trypanosoma cruzi extracellular receptor, putative 0.0109 0.0452 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0082 0.0338
Schistosoma mansoni glutaminase 0.0275 0.1495 0.4794
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0001 0.0021
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0001 0.0021
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0001 0.0006
Echinococcus multilocularis glutamate receptor 2 0.0424 0.2433 0.2433
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0533 0.3117 0.7258
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.0123 0.0541 0.2225
Schistosoma mansoni glutamate receptor kainate 0.0424 0.2433 0.7804
Schistosoma mansoni glutamate receptor AMPA 0.0424 0.2433 0.7804
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0533 0.3117 0.7258
Loa Loa (eye worm) glutaminase 0.0275 0.1495 0.6143
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0508 0.296 0.5
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0109 0.0452 0.1857
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0212 0.1102 0.2567
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0508 0.296 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0533 0.3117 0.3117
Echinococcus granulosus metabotropic glutamate receptor 5 0.0109 0.0452 0.1052
Loa Loa (eye worm) hypothetical protein 0.0164 0.0799 0.3282
Schistosoma mansoni tyrosine kinase 0.0109 0.0452 0.1449
Echinococcus granulosus metabotropic glutamate receptor 2 0.0109 0.0452 0.1052
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0151 0.0484
Schistosoma mansoni glutamate receptor kainate 0.0424 0.2433 0.7804
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0001 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0055 0.0178
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0001 0.0001
Schistosoma mansoni alpha-glucosidase 0.014 0.0651 0.2088
Loa Loa (eye worm) hypothetical protein 0.0123 0.0541 0.2225
Echinococcus multilocularis tyrosine kinase 0.0109 0.0452 0.0452
Trichomonas vaginalis glutaminase, putative 0.0275 0.1495 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0794 0.3263
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0001 0.0021
Echinococcus multilocularis glutamate receptor 2 0.0533 0.3117 0.3117
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0001 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0082 0.0338
Loa Loa (eye worm) glutamate receptor 0.0109 0.0452 0.1857
Brugia malayi glutaminase DH11.1 0.0275 0.1495 0.6143
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0001 0.0003
Brugia malayi metabotropic glutamate receptor type 2 0.0109 0.0452 0.1857
Echinococcus granulosus glutamate receptor 2 0.032 0.1782 0.4149
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0151 0.3342
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0794 0.3263
Brugia malayi Receptor family ligand binding region containing protein 0.0109 0.0452 0.1857
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0055 0.0228
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0794 0.0794
Brugia malayi Glutamate receptor 1 precursor 0.0424 0.2433 1
Echinococcus granulosus atrial natriuretic peptide receptor 0.0109 0.0452 0.1052
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0001 0.0004
Echinococcus granulosus receptor type guanylyl cyclase 0.0109 0.0452 0.1052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0055 0.0129
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.2681 0.2681
Brugia malayi hypothetical protein 0.0123 0.0541 0.2225
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0533 0.3117 0.3117
Loa Loa (eye worm) RGC/RGC protein kinase 0.0109 0.0452 0.1857
Brugia malayi hypothetical protein 0.0109 0.0452 0.1857
Echinococcus granulosus tyrosine kinase 0.0109 0.0452 0.1052
Brugia malayi hypothetical protein 0.0164 0.0799 0.3282
Loa Loa (eye worm) hypothetical protein 0.0109 0.0452 0.1857
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0075 0.024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0151 0.051
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0794 0.1848
Echinococcus multilocularis NMDA receptor 0.0212 0.1102 0.1102
Loa Loa (eye worm) hypothetical protein 0.0109 0.0452 0.1857
Loa Loa (eye worm) hypothetical protein 0.0109 0.0452 0.1857
Loa Loa (eye worm) hypothetical protein 0.0109 0.0452 0.1857
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0001 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0082 0.0338
Loa Loa (eye worm) hypothetical protein 0.0109 0.0452 0.1857
Brugia malayi Glutamate receptor 2 precursor 0.0424 0.2433 1
Schistosoma mansoni glutamate receptor AMPA 0.0424 0.2433 0.7804
Schistosoma mansoni single-minded 0.0049 0.0075 0.024
Mycobacterium ulcerans glutaminase 0.0275 0.1495 0.5049
Onchocerca volvulus Huntingtin homolog 0.0123 0.0541 1
Leishmania major extracellular receptor, putative 0.0109 0.0452 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0055 0.0178
Loa Loa (eye worm) glutamate receptor 2 0.0424 0.2433 1
Schistosoma mansoni protein kinase 0.0109 0.0452 0.1449
Loa Loa (eye worm) hypothetical protein 0.0109 0.0452 0.1857
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0109 0.0452 0.1857
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0109 0.0452 0.0452
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0 0.5
Schistosoma mansoni metabotropic glutamate receptor 0.0109 0.0452 0.1449
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0533 0.3117 0.3117
Echinococcus granulosus nmda type glutamate receptor 0.072 0.4295 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0109 0.0452 0.1857
Schistosoma mansoni glutamate receptor NMDA 0.0424 0.2433 0.7804
Echinococcus multilocularis glutamate receptor 2 0.032 0.1782 0.1782
Loa Loa (eye worm) hypothetical protein 0.0037 0.0001 0.0004
Echinococcus granulosus nmda type glutamate receptor 0.0109 0.0452 0.1052
Brugia malayi Metabotropic glutamate receptor precursor. 0.0109 0.0452 0.1857
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0151 0.0151
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0212 0.1102 0.2567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0055 0.0129
Loa Loa (eye worm) hypothetical protein 0.0109 0.0452 0.1857
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0001 0.0006
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0151 0.0484
Echinococcus multilocularis nmda type glutamate receptor 0.0109 0.0452 0.0452
Echinococcus granulosus glutamate NMDA receptor subunit 0.0424 0.2433 0.5664
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0001 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0109 0.0452 0.1857
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0533 0.3117 0.3117
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0109 0.0452 0.0452
Schistosoma mansoni glutamate receptor kainate 0.0424 0.2433 0.7804

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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