Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.1276 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0378 | 0.8551 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.1132 | 0.8869 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.1276 | 0.1189 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.1276 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.1276 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.1276 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.1276 | 0.5 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.1276 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.1276 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.1276 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.1276 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.1276 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.005 | 0.0122 | 0.0954 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.1276 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.1276 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0056 | 0.0295 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.1276 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.1276 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.1276 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0435 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.1276 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0056 | 0.0295 | 0.5 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.1132 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.1132 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.73 uM | Inhibitory activity of the compound against (IMPDH) inosine 5'-monophosphate dehydrogenase | ChEMBL. | 12729643 |
IC50 (binding) | = 0.73 uM | Inhibitory activity of the compound against (IMPDH) inosine 5'-monophosphate dehydrogenase | ChEMBL. | 12729643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.