Detailed information for compound 685848

Basic information

Technical information
  • TDR Targets ID: 685848
  • Name: 1-(4-bromophenyl)sulfonyl-N,N-diethyl-3,5-dim ethylpyrazole-4-sulfonamide
  • MW: 450.371 | Formula: C15H20BrN3O4S2
  • H donors: 0 H acceptors: 5 LogP: 2.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1c(C)nn(c1C)S(=O)(=O)c1ccc(cc1)Br)CC
  • InChi: 1S/C15H20BrN3O4S2/c1-5-18(6-2)25(22,23)15-11(3)17-19(12(15)4)24(20,21)14-9-7-13(16)8-10-14/h7-10H,5-6H2,1-4H3
  • InChiKey: SXMSNGYWMGLSEH-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-(4-bromophenyl)sulfonyl-N,N-diethyl-3,5-dimethyl-pyrazole-4-sulfonamide
  • 1-(4-bromophenyl)sulfonyl-N,N-diethyl-3,5-dimethyl-4-pyrazolesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.6548 0.5907
Entamoeba histolytica recQ family helicase, putative 0.0021 0.6548 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0249 0.0249
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.6548 0.5907
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.6548 0.5
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.2432 0.2239
Echinococcus granulosus bloom syndrome protein 0.0021 0.6548 0.5907
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.6548 0.5438
Loa Loa (eye worm) intermediate filament protein 0.0026 1 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.6548 0.5
Echinococcus multilocularis lamin dm0 0.0026 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.6548 1
Schistosoma mansoni lamin 0.0026 1 1
Echinococcus multilocularis lamin 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.1269 0.1046
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0249 0.5
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.6548 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 1 1
Onchocerca volvulus 0.0026 1 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.6548 1
Schistosoma mansoni DNA helicase recq5 0.0021 0.6548 0.6548
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.6548 0.5
Onchocerca volvulus 0.0026 1 0.5
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.6548 0.5
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.6548 0.646
Echinococcus granulosus lamin 0.0026 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.6548 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.6548 0.5
Schistosoma mansoni intermediate filament proteins 0.0026 1 1
Loa Loa (eye worm) RecQ helicase 0.0021 0.6548 0.646
Loa Loa (eye worm) hypothetical protein 0.0012 0.1269 0.1046
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.6548 0.5438
Schistosoma mansoni lamin 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.6548 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.6548 0.646
Schistosoma mansoni DNA helicase recq1 0.0021 0.6548 0.6548
Brugia malayi Intermediate filament tail domain containing protein 0.0026 1 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.6548 0.5907
Loa Loa (eye worm) hypothetical protein 0.0011 0.0249 0.0000000054327
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.6548 0.5
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.6548 0.5438
Echinococcus granulosus lamin dm0 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.9702 0.9694
Echinococcus granulosus intermediate filament protein 0.0026 1 1
Echinococcus multilocularis musashi 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.1567 0.1351
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.6548 0.5907
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0249 0.0381
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0249 0.0381
Echinococcus multilocularis bloom syndrome protein 0.0021 0.6548 0.5907
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0249 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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