TDR Targets

Basic information

Technical information

TDR Targets ID: 686574
Name: 2-[[1-(2-hydroxyethyl)-2-oxo-5,6,7,8-tetrahyd roquinazolin-4-yl]sulfanyl]-N-(3-nitrophenyl) acetamide
MW: 404.44 | Formula: C18H20N4O5S
H donors: 2 H acceptors: 5 LogP: 1.66 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OCCn1c(=O)nc(c2c1CCCC2)SCC(=O)Nc1cccc(c1)[N+](=O)[O-]
InChi: 1S/C18H20N4O5S/c23-9-8-21-15-7-2-1-6-14(15)17(20-18(21)25)28-11-16(24)19-12-4-3-5-13(10-12)22(26)27/h3-5,10,23H,1-2,6-9,11H2,(H,19,24)
InChiKey: RYXOURYTWQESFM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[1-(2-hydroxyethyl)-2-oxo-5,6,7,8-tetrahydroquinazolin-4-yl]thio]-N-(3-nitrophenyl)acetamide
2-[[1-(2-hydroxyethyl)-2-keto-5,6,7,8-tetrahydroquinazolin-4-yl]thio]-N-(3-nitrophenyl)acetamide
2-[[1-(2-hydroxyethyl)-2-oxo-5,6,7,8-tetrahydroquinazolin-4-yl]sulfanyl]-N-(3-nitrophenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0209	0.395
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0251	0.0251
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0215	0.3884	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0381	0.7919
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0099	0.1653	0.2282
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0215	0.3884	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Echinococcus granulosus	tar DNA binding protein	0.0072	0.1129	0.284
Trypanosoma brucei	glucose transporter, putative	0.0034	0.039	0.8107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Entamoeba histolytica	hypothetical protein	0.0116	0.1974	1
Leishmania major	hypothetical protein, conserved	0.0028	0.0274	0.5451
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0116	0.1974	0.5036
Entamoeba histolytica	hypothetical protein	0.0039	0.0501	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0099	0.1653	0.4203
Trypanosoma brucei	glucose transporter 1E	0.0034	0.039	0.8107
Brugia malayi	TAR-binding protein	0.0072	0.1129	0.1542
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0215	0.3884	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0215	0.3884	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0215	0.3884	0.5431
Loa Loa (eye worm)	acetylcholine receptor protein	0.0099	0.1653	0.1653
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.039	0.1973
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0291	0.0663
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.1827	0.4654
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1974	0.1974
Schistosoma mansoni	neurotransmitter gated ion channel	0.0099	0.1653	0.4203
Onchocerca volvulus		0.0215	0.3884	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1974	0.1974
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0342	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1974	0.1974
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.1827	0.4654
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0274	0.5451
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0274	0.0274
Loa Loa (eye worm)	sugar transporter	0.0108	0.1827	0.1827
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.039	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1974	0.1974
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0382	0.0617
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.039	0.8107
Schistosoma mansoni	nAChR subunit	0.0099	0.1653	0.4203
Loa Loa (eye worm)	LGC-31 protein	0.0215	0.3884	0.3884
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0369	0.0469
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0291	0.0298
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0472	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0381	0.0897
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0099	0.1653	0.4203
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0381	0.0381
Schistosoma mansoni	hypothetical protein	0.0108	0.1827	0.4654
Brugia malayi	Cam kinase protein 1	0.0033	0.0381	0.0487
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0215	0.3884	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0382	0.0404
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0472	0.051
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0215	0.3884	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.039	0.8107
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0099	0.1653	0.1653
Schistosoma mansoni	glucose transport protein	0.0108	0.1827	0.4654
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0382	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0209	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0215	0.3884	1
Schistosoma mansoni	nAChR subunit	0.0215	0.3884	1
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0291	0.768
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0116	0.1974	0.2735
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Echinococcus granulosus	General substrate transporter	0.0093	0.1534	0.3893
Brugia malayi	RNA binding protein	0.0072	0.1129	0.1542
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0501	0.1206
Echinococcus granulosus	nAChR subunit	0.0215	0.3884	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0116	0.1974	0.2735
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0382	0.0404
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0209	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.039	0.1973
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0382	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1974	0.1974
Brugia malayi	excitatory GABA receptor EXP-1A	0.0215	0.3884	0.5431
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.1129	0.284
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0215	0.3884	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0108	0.1827	0.4654
Brugia malayi	Flap endonuclease-1	0.0028	0.0291	0.036
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.1827	0.4654
Brugia malayi	Cytochrome P450 family protein	0.003	0.0316	0.0394
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0209	0.0201
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0382	0.0404
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0215	0.3884	1
Trypanosoma brucei	glucose transporter, putative	0.0034	0.039	0.8107
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0381	0.0381
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0215	0.3884	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1974	0.1974
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0175	0.3111	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0215	0.3884	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0215	0.3884	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0175	0.3111	0.3595
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0116	0.1974	0.2735
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0291	0.0298
Brugia malayi	hypothetical protein	0.0018	0.0086	0.007
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0472	0.0779
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0215	0.3884	0.3884
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0369	0.0863
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0099	0.1653	0.2282
Leishmania major	glucose transporter, lmgt3	0.0034	0.039	0.8107
Onchocerca volvulus		0.0099	0.1653	0.4203
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0215	0.3884	0.3884
Echinococcus multilocularis	glycine receptor subunit beta	0.0215	0.3884	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0209	0.395
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0097	0.1383
Onchocerca volvulus	Putative nachr subunit	0.0215	0.3884	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0215	0.3884	0.3884
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0369	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0215	0.3884	0.5431
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0274	0.0278
Brugia malayi	hypothetical protein	0.0028	0.0274	0.0335
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0215	0.3884	0.5431
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0209	0.0447
Onchocerca volvulus		0.0116	0.1974	0.5036
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0215	0.3884	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0291	0.0456
Echinococcus granulosus	nAChR subunit	0.0116	0.1974	0.5036
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0116	0.1974	0.5036
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.039	0.1973
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0209	1
Brugia malayi	hypothetical protein	0.0099	0.1653	0.2282
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0382	0.0404
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0099	0.1653	0.2282
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0381	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0369	0.0369
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0175	0.3111	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Loa Loa (eye worm)	sugar transporter	0.0015	0.0036	0.0036
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0215	0.3884	1
Loa Loa (eye worm)	hypothetical protein	0.0284	0.5212	0.5212
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0382	0.0404
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0215	0.3884	0.3884
Onchocerca volvulus		0.0215	0.3884	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0215	0.3884	0.5431
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0209	0.0447
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0472	1
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0099	0.1653	0.4203
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0369	0.0906
Echinococcus multilocularis	nAChR subunit	0.0215	0.3884	1
Onchocerca volvulus		0.0116	0.1974	0.5036
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.039	0.1973
Trypanosoma brucei	glucose transporter 2A	0.0034	0.039	0.8107
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0099	0.1653	0.4203
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0215	0.3884	0.3884
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0215	0.3884	1
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.1129	0.284
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0034	0.039	0.8107
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.1827	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0215	0.3884	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0215	0.3884	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Leishmania major	protein kinase, putative	0.0033	0.0381	0.7919
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0382	0.0617
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0215	0.3884	0.3884
Echinococcus multilocularis	nAChR subunit	0.0116	0.1974	0.5036
Brugia malayi	Cation transporter family protein	0.0215	0.3884	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Schistosoma mansoni	neurotransmitter gated ion channel	0.0099	0.1653	0.4203
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0209	0.5182
Schistosoma mansoni	protein kinase	0.0033	0.0381	0.0897
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Trypanosoma cruzi	hexose transporter	0.0034	0.039	0.8107
Loa Loa (eye worm)	ACC-1 protein	0.0215	0.3884	0.3884
Schistosoma mansoni	glucose transport protein	0.0108	0.1827	0.4654
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Schistosoma mansoni	protein kinase	0.0033	0.0381	0.0897
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0138	1
Loa Loa (eye worm)	TAR-binding protein	0.0072	0.1129	0.1129
Schistosoma mansoni	nAChR subunit	0.0215	0.3884	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0382	0.0617
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0274	0.0278
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0215	0.3884	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0215	0.3884	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0274	0.5451
Brugia malayi	Cation transporter family protein	0.0215	0.3884	0.5431
Entamoeba histolytica	hypothetical protein	0.0039	0.0501	0.1654
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0209	0.0961
Entamoeba histolytica	hypothetical protein	0.0039	0.0501	0.1654
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0215	0.3884	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0209	0.3046
Schistosoma mansoni	nAChR subunit	0.0215	0.3884	1
Echinococcus granulosus	glycine receptor subunit beta	0.0215	0.3884	1
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0215	0.3884	0.5431
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0459	0.8588	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Toxoplasma gondii	facilitative glucose transporter GT1	0.0108	0.1827	0.3201
Leishmania major	glucose transporter, lmgt2	0.0034	0.039	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Brugia malayi	RNA recognition motif domain containing protein	0.0072	0.1129	0.1542
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1974	0.1974
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0209	0.395
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0369	0.0469
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.1129	0.284
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0072	0.1129	0.1129
Schistosoma mansoni	nAChR subunit	0.0215	0.3884	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Schistosoma mansoni	nAChR subunit	0.0215	0.3884	1
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0291	0.5854
Echinococcus granulosus	glycine receptor subunit beta	0.0215	0.3884	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0099	0.1653	0.2282
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0099	0.1653	0.2282
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.1129	0.284
Trypanosoma brucei	glucose transporter, putative	0.0034	0.039	0.8107
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0215	0.3884	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.1827	0.4654
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0116	0.1974	0.2735
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0215	0.3884	0.5431
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0291	0.5854
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0316	0.0316
Brugia malayi	hypothetical protein	0.0099	0.1653	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0215	0.3884	0.5431
Loa Loa (eye worm)	GABA receptor subunit	0.0116	0.1974	0.1974
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0472	1
Onchocerca volvulus		0.0215	0.3884	1
Brugia malayi	Sugar transporter family protein	0.0108	0.1827	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Loa Loa (eye worm)	RNA binding protein	0.0072	0.1129	0.1129
Onchocerca volvulus		0.0215	0.3884	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0369	0.1855
Trypanosoma brucei	glucose transporter, putative	0.0034	0.039	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.039	0.1973
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0381	0.1927
Echinococcus multilocularis	General substrate transporter	0.0093	0.1534	0.3893
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0215	0.3884	0.5431
Schistosoma mansoni	nAChR subunit	0.0099	0.1653	0.4203
Onchocerca volvulus		0.0099	0.1653	0.4203
Toxoplasma gondii	protein kinase, putative	0.0306	0.5631	1
Trypanosoma brucei	glucose transporter, putative	0.0034	0.039	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Brugia malayi	hypothetical protein	0.0039	0.0501	0.0655
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0099	0.1653	0.4203
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0099	0.1653	0.4203
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0291	0.1424
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0209	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Leishmania major	glucose transporter, lmgt1	0.0034	0.039	0.8107
Trypanosoma brucei	glucose transporter, putative	0.0034	0.039	0.8107
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.039	0.8107
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0291	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0099	0.1653	0.2282
Schistosoma mansoni	flap endonuclease-1	0.0026	0.0239	0.0526
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0215	0.3884	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0381	0.0487
Onchocerca volvulus		0.0215	0.3884	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0036	0.0036
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0369	0.0863
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0215	0.3884	0.5431
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0291	0.047
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0291	0.5854
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0215	0.3884	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0501	0.1206
Plasmodium falciparum	protein kinase 6	0.0459	0.8588	1
Brugia malayi	hypothetical protein	0.0099	0.1653	0.2282
Trypanosoma brucei	glucose transporter, putative	0.0034	0.039	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0501	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.039	0.8107
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.039	0.1973
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0369	0.0863
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.1827	0.4654
Schistosoma mansoni	neurotransmitter gated ion channel	0.0116	0.1974	0.5036
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0472	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0381	0.098
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0382	0.0404
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.039	0.1973
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0036	0.0036
Loa Loa (eye worm)	ACC-1 protein	0.0215	0.3884	0.3884
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0215	0.3884	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0215	0.3884	1
Schistosoma mansoni	nAChR subunit	0.0215	0.3884	1
Plasmodium vivax	hexose transporter	0.0108	0.1827	0.2094
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0342	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1974	0.1974
Plasmodium falciparum	hexose transporter	0.0108	0.1827	0.2094
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0209	0.0447
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0215	0.3884	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0369	0.0863
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0215	0.3884	1
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0381	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0472	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0383	0.7122	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0209	1
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0472	0.051
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0215	0.3884	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Schistosoma mansoni	nAChR subunit	0.0215	0.3884	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Schistosoma mansoni	glucose transport protein	0.0108	0.1827	0.4654
Brugia malayi	hypothetical protein	0.0099	0.1653	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Schistosoma mansoni	protein kinase	0.0033	0.0381	0.0897
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0209	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0369	0.0369
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0215	0.3884	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.039	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0369	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0151	0.0641
Onchocerca volvulus		0.0215	0.3884	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.7122	0.7122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0215	0.3884	1
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.1129	0.284
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0382	0.0404
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Schistosoma mansoni	acetylcholine receptor-related	0.0099	0.1653	0.4203
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0138	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0215	0.3884	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0274	0.0425
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0036	0.5
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0215	0.3884	0.5431
Entamoeba histolytica	hypothetical protein	0.0039	0.0501	0.1654
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0099	0.1653	0.1653
Trypanosoma brucei	glucose transporter, putative	0.0034	0.039	0.8107
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0291	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.1827	0.4654
Schistosoma mansoni	hypothetical protein	0.0039	0.0501	0.1206
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.1827	0.4654
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0274	0.0278
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0215	0.3884	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1653	0.1653
Onchocerca volvulus		0.0099	0.1653	0.4203
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0209	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Brugia malayi	hypothetical protein	0.0099	0.1653	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0215	0.3884	0.3884
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0274	0.5451
Plasmodium falciparum	protein kinase 7	0.0306	0.5631	0.6542
Brugia malayi	Cation transporter family protein	0.0215	0.3884	0.5431
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0215	0.3884	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0381	0.098
Echinococcus multilocularis	tar DNA binding protein	0.0072	0.1129	0.284

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 686574