TDR Targets

Basic information

Technical information

TDR Targets ID: 686724
Name: N'-[(4-methylphenyl)methyl]-N-[2-(4-methylphe nyl)-2-morpholin-4-ylethyl]oxamide
MW: 395.495 | Formula: C23H29N3O3
H donors: 2 H acceptors: 2 LogP: 2.67 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)CNC(=O)C(=O)NCC(c1ccc(cc1)C)N1CCOCC1
InChi: 1S/C23H29N3O3/c1-17-3-7-19(8-4-17)15-24-22(27)23(28)25-16-21(26-11-13-29-14-12-26)20-9-5-18(2)6-10-20/h3-10,21H,11-16H2,1-2H3,(H,24,27)(H,25,28)
InChiKey: ZOSNPNXPJHWMSS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-[(4-methylphenyl)methyl]-N-[2-(4-methylphenyl)-2-morpholino-ethyl]oxamide
N'-[(4-methylphenyl)methyl]-N-[2-(4-methylphenyl)-2-morpholinoethyl]oxamide
N'-(4-methylbenzyl)-N-[2-(4-methylphenyl)-2-morpholino-ethyl]oxamide
N'-[(4-methylphenyl)methyl]-N-[2-(4-methylphenyl)-2-morpholin-4-yl-ethyl]ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0022	0.0107	0.0157
Brugia malayi	MH2 domain containing protein	0.0116	0.1584	0.2329
Trichomonas vaginalis	CAMK family protein kinase	0.0447	0.6799	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.1283	0.1887
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0022	0.0107	0.0157
Echinococcus granulosus	insulin receptor	0.0095	0.1256	0.1847
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0022	0.0107	0.0107
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0022	0.0107	0.0157
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0241	0.0354
Echinococcus multilocularis	geminin	0.0165	0.2349	0.3455
Schistosoma mansoni	hypothetical protein	0.0031	0.0241	0.0241
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.1283	0.1887
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0066	0.079	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1283	0.1887
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.012	0.1652	0.243
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0022	0.0107	0.0157
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0022	0.0107	0.0107
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.016	0.2272	0.3342
Loa Loa (eye worm)	raf kinase	0.0208	0.3037	0.4466
Echinococcus granulosus	GPCR family 2	0.0031	0.0241	0.0354
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0022	0.0107	0.0157
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0159	0.2265	0.3331
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0022	0.0107	0.0107
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0022	0.0107	0.1353
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0107	0.1353
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0022	0.0107	0.0157
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Schistosoma mansoni	hypothetical protein	0.0035	0.0308	0.0308
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0308	0.0308
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0022	0.0107	0.0107
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0022	0.0107	0.0157
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Chlamydia trachomatis	dihydrofolate reductase	0.0171	0.2456	0.5
Brugia malayi	serine/threonine-protein kinase plk-2	0.0447	0.6799	1
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0066	0.079	0.1162
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0022	0.0107	0.0157
Trypanosoma brucei	polo-like protein kinase	0.0447	0.6799	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0095	0.1256	0.1847
Echinococcus multilocularis	dihydrofolate reductase	0.0171	0.2456	0.3613
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0107	0.0157
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0022	0.0107	0.0107
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0308	0.0454
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0182	0.2621	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0022	0.0107	0.0157
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1584	0.2329
Leishmania major	hypothetical protein, conserved	0.0022	0.0107	0.0157
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0171	0.2456	0.5
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0022	0.0107	0.0157
Trichomonas vaginalis	CAMK family protein kinase	0.0447	0.6799	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0241	0.0354
Echinococcus granulosus	epidermal growth factor receptor	0.0295	0.4409	0.6485
Leishmania major	hypothetical protein, conserved	0.0022	0.0107	0.0157
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0022	0.0107	0.0157
Brugia malayi	Furin-like cysteine rich region family protein	0.0295	0.4409	0.6485
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0107	0.0157
Echinococcus granulosus	Serine:threonine protein kinase PLK4	0.0351	0.5287	0.7777
Echinococcus multilocularis	epidermal growth factor receptor	0.0159	0.2265	0.3331
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0182	0.2621	0.3855
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0022	0.0107	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0107	0.0157
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0061	0.0724	0.1065
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0022	0.0107	0.1353
Trichomonas vaginalis	CAMK family protein kinase	0.0148	0.2086	0.2958
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0107	0.0157
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0061	0.0724	0.1065
Trypanosoma brucei	hypothetical protein, conserved	0.0022	0.0107	0.0157
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.016	0.2272	0.3342
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0066	0.079	0.3014
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0182	0.2621	0.3855
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1584	0.2329
Brugia malayi	hypothetical protein	0.0294	0.4379	0.644
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0022	0.0107	0.0157
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0182	0.2621	0.3855
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0107	0.0157
Plasmodium vivax	phosphodiesterase gamma, putative	0.0022	0.0107	0.1353
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0022	0.0107	0.0157
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0241	0.0354
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0447	0.6799	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0022	0.0107	0.0157
Brugia malayi	hypothetical protein	0.0035	0.0308	0.0454
Trypanosoma cruzi	polo-like protein kinase, putative	0.0447	0.6799	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Schistosoma mansoni	tyrosine kinase	0.0095	0.1256	0.1256
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0062	0.0731	0.1074
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.08	0.1177
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0107	0.1353
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0022	0.0107	0.0107
Loa Loa (eye worm)	dihydrofolate reductase	0.0171	0.2456	0.3613
Echinococcus granulosus	dihydrofolate reductase	0.0171	0.2456	0.3613
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0066	0.079	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0241	0.0241
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0022	0.0107	0.0157
Schistosoma mansoni	dihydrofolate reductase	0.0171	0.2456	0.2456
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0022	0.0107	0.0107
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0022	0.0107	0.1353
Giardia lamblia	Kinase, PLK	0.0447	0.6799	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0241	0.0241
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0107	0.0157
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0022	0.0107	0.0157
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0447	0.6799	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0107	0.1353
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0022	0.0107	0.0157
Trichomonas vaginalis	CAMK family protein kinase	0.0447	0.6799	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0295	0.4409	0.6485
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0066	0.079	0.1162
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0447	0.6799	1
Trichomonas vaginalis	CAMK family protein kinase	0.0447	0.6799	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0022	0.0107	0.0157
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0022	0.0107	0.0157
Brugia malayi	dihydrofolate reductase family protein	0.0171	0.2456	0.3613
Brugia malayi	Protein kinase domain containing protein	0.0095	0.1256	0.1847
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0241	0.0354
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0447	0.6799	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0022	0.0107	0.0157
Trichomonas vaginalis	CAMK family protein kinase	0.0447	0.6799	1
Trichomonas vaginalis	CAMK family protein kinase	0.0447	0.6799	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0107	0.0157
Schistosoma mansoni	tyrosine kinase	0.0295	0.4409	0.4409
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0171	0.2456	0.5
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0182	0.2621	0.3757
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0022	0.0107	0.0157
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0295	0.4409	0.6485
Echinococcus multilocularis	insulin receptor	0.0095	0.1256	0.1847
Schistosoma mansoni	tyrosine kinase	0.0095	0.1256	0.1256
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.1283	0.1887
Echinococcus granulosus	raf serine:threonine protein kinase	0.0211	0.3079	0.4529
Schistosoma mansoni	tyrosine kinase	0.0159	0.2265	0.2265
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0022	0.0107	0.1353
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0095	0.1256	0.1847
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0022	0.0107	0.0157
Schistosoma mansoni	serine/threonine protein kinase	0.0211	0.3079	0.3079
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0022	0.0107	0.0157
Schistosoma mansoni	tyrosine kinase	0.0157	0.2222	0.2222
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0022	0.0107	0.1353
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0022	0.0107	0.0157
Trypanosoma cruzi	polo-like protein kinase, putative	0.0447	0.6799	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.08	0.1177
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0241	0.0354
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.016	0.2272	0.3342
Echinococcus multilocularis		0.0091	0.1193	0.1755
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0022	0.0107	0.0107
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Echinococcus multilocularis	Serine:threonine protein kinase PLK4	0.0351	0.5287	0.7777
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0022	0.0107	0.0157
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0022	0.0107	0.0157
Echinococcus granulosus	geminin	0.0165	0.2349	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0241	0.0354
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0022	0.0107	0.0107
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Brugia malayi	Raf kinase	0.0204	0.2964	0.436
Schistosoma mansoni	hypothetical protein	0.0165	0.2349	0.2349
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0066	0.079	0.1162
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0022	0.0107	0.0157
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0241	0.0354
Trichomonas vaginalis	CAMK family protein kinase	0.0148	0.2086	0.2958
Loa Loa (eye worm)	hypothetical protein	0.0182	0.2621	0.3855
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0182	0.2621	0.3855
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0447	0.6799	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0241	0.0354
Trichomonas vaginalis	CAMK family protein kinase	0.0447	0.6799	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0241	0.0241
Brugia malayi	Dihydrofolate reductase	0.0171	0.2456	0.3613
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0022	0.0107	0.0157
Schistosoma mansoni	tyrosine kinase	0.0157	0.2222	0.2222
Echinococcus granulosus	epidermal growth factor receptor	0.0159	0.2265	0.3331
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0241	0.0354
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0022	0.0107	0.0157
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.016	0.2272	0.3342
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0211	0.3079	0.4529
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0107	0.0157
Plasmodium falciparum	phosphodiesterase delta, putative	0.0022	0.0107	0.1353
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0022	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0165	0.2349	0.2349
Schistosoma mansoni	tyrosine kinase	0.0157	0.2222	0.2222
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0107	0.0157
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0107	0.0157
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0107	0.0157
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0308	0.0454
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0022	0.0107	0.0157
Brugia malayi	Protein kinase domain containing protein	0.0061	0.0724	0.1065
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0107	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0294	0.4379	0.644
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0447	0.6799	1
Schistosoma mansoni	serine/threonine protein kinase	0.0447	0.6799	0.6799
Schistosoma mansoni	tyrosine kinase	0.0159	0.2265	0.2265
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0182	0.2621	0.2621
Loa Loa (eye worm)	PDE1B protein	0.0022	0.0107	0.0157
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0095	0.1256	0.1847
Schistosoma mansoni	hypothetical protein	0.0066	0.08	0.08
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0022	0.0107	0.0157
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0022	0.0107	0.0157
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0171	0.2456	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 686724