Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Prolyl endopeptidase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | oligopeptidase B | Prolyl endopeptidase | 710 aa | 716 aa | 23.3 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.7 % |
Trypanosoma brucei | oligopeptidase b | Prolyl endopeptidase | 710 aa | 626 aa | 27.2 % |
Leishmania infantum | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 720 aa | 25.1 % |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | Prolyl endopeptidase | 710 aa | 713 aa | 26.4 % |
Leishmania major | oligopeptidase b | Prolyl endopeptidase | 710 aa | 718 aa | 25.2 % |
Leishmania donovani | oligopeptidase b | Prolyl endopeptidase | 710 aa | 720 aa | 25.1 % |
Trypanosoma brucei gambiense | oligopeptidase B, putative | Prolyl endopeptidase | 710 aa | 626 aa | 27.2 % |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | Prolyl endopeptidase | 710 aa | 735 aa | 25.6 % |
Trypanosoma congolense | oligopeptidase b | Prolyl endopeptidase | 710 aa | 588 aa | 27.6 % |
Leishmania braziliensis | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 600 aa | 25.7 % |
Onchocerca volvulus | Prolyl endopeptidase | 710 aa | 724 aa | 46.7 % | |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.7 % |
Leishmania mexicana | oligopeptidase b,serine peptidase, clan SC, family S9A-like protein | Prolyl endopeptidase | 710 aa | 723 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0063 | 0 | 0.5 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0158 | 1 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0158 | 1 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0063 | 0 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0158 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.8259 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0158 | 1 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 1 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0158 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0158 | 1 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 1 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0158 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 34 nM | Inhibitory activity against rat brain Prolyl endopeptidase (PEP) | ChEMBL. | No reference |
IC50 (binding) | = 34 nM | Inhibitory activity against rat brain Prolyl endopeptidase (PEP) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.