Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0118 | 0.2846 | 1 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0159 | 0.4609 | 0.5737 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0237 | 0.8034 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0237 | 0.8034 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0239 | 0.8095 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0237 | 0.8034 | 0.8643 |
Mycobacterium ulcerans | glutaminase | 0.0266 | 0.9295 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0266 | 0.9295 | 1 |
Schistosoma mansoni | glutaminase | 0.0266 | 0.9295 | 0.9295 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0239 | 0.8095 | 0.5 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0183 | 0.5672 | 0.706 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0146 | 0.0157 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0237 | 0.8034 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0237 | 0.8034 | 0.8643 |
Brugia malayi | thymidylate synthase | 0.0118 | 0.2846 | 0.3061 |
Echinococcus granulosus | kinesin family 1 | 0.0211 | 0.6904 | 0.8594 |
Trichomonas vaginalis | glutaminase, putative | 0.0266 | 0.9295 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0118 | 0.2846 | 0.2846 |
Brugia malayi | glutaminase DH11.1 | 0.0266 | 0.9295 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0118 | 0.2846 | 0.3542 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0159 | 0.4609 | 0.4959 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0237 | 0.8034 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0118 | 0.2846 | 0.3542 |
Echinococcus multilocularis | kinesin family 1 | 0.0211 | 0.6904 | 0.8594 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0239 | 0.8095 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 0.9295 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0118 | 0.2846 | 0.3061 |
Schistosoma mansoni | dihydrofolate reductase | 0.0237 | 0.8034 | 0.8034 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0159 | 0.4609 | 0.5737 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0239 | 0.8095 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0159 | 0.4609 | 0.5737 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0118 | 0.2846 | 0.3423 |
Brugia malayi | dihydrofolate reductase family protein | 0.0237 | 0.8034 | 0.8643 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.3646 | 0.3646 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0239 | 0.8095 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.3646 | 0.3646 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0183 | 0.5672 | 0.706 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0237 | 0.8034 | 0.8044 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0239 | 0.8095 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.5708 | 0.5708 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0237 | 0.8034 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0159 | 0.4609 | 0.4959 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.