Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.1708 | 0.199 |
Onchocerca volvulus | 0.0149 | 0.2853 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2853 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0376 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0331 | 0.8583 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0376 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0376 | 1 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0082 | 0.0774 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0376 | 1 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0082 | 0.0774 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0774 | 0.2713 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.8583 | 1 |
Brugia malayi | hypothetical protein | 0.0149 | 0.2853 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0376 | 1 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0376 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0331 | 0.8583 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.8583 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0112 | 0.1708 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.