Detailed information for compound 690617

Basic information

Technical information
  • TDR Targets ID: 690617
  • Name: N'-(2,2-diethoxyethyl)-N-[2-furan-2-yl-2-(4-p henylpiperazin-1-yl)ethyl]oxamide
  • MW: 458.551 | Formula: C24H34N4O5
  • H donors: 2 H acceptors: 2 LogP: 2.11 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(CNC(=O)C(=O)NCC(c1ccco1)N1CCN(CC1)c1ccccc1)OCC
  • InChi: 1S/C24H34N4O5/c1-3-31-22(32-4-2)18-26-24(30)23(29)25-17-20(21-11-8-16-33-21)28-14-12-27(13-15-28)19-9-6-5-7-10-19/h5-11,16,20,22H,3-4,12-15,17-18H2,1-2H3,(H,25,29)(H,26,30)
  • InChiKey: CNJAOFRXCMGOAA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N'-(2,2-diethoxyethyl)-N-[2-(2-furyl)-2-(4-phenylpiperazin-1-yl)ethyl]oxamide
  • N'-(2,2-diethoxyethyl)-N-[2-(2-furyl)-2-(4-phenyl-1-piperazinyl)ethyl]oxamide
  • N'-(2,2-diethoxyethyl)-N-[2-furan-2-yl-2-(4-phenylpiperazin-1-yl)ethyl]ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0029 0.0552 0.0537
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.023 0.0215
Plasmodium falciparum peptide deformylase 0.0237 0.5662 1
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Echinococcus multilocularis pyruvate kinase 0.0017 0.0264 0.0249
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0667 0.2387
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0936 0.0922
Schistosoma mansoni hypothetical protein 0.0034 0.0685 0.067
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1077 0.3882
Schistosoma mansoni cpg binding protein 0.0031 0.0593 0.0578
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0056 0.0158
Trypanosoma cruzi Peptide deformylase 2, putative 0.0091 0.206 1
Treponema pallidum polypeptide deformylase (def) 0.0237 0.5662 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.023 0.0215
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.023 0.0215
Entamoeba histolytica hypothetical protein 0.0035 0.0694 1
Schistosoma mansoni pyruvate kinase 0.0034 0.0667 0.0653
Brugia malayi Latrophilin receptor protein 2 0.0016 0.023 0.0793
Echinococcus granulosus pyruvate kinase 0.0034 0.0667 0.0653
Schistosoma mansoni pyruvate kinase 0.0034 0.0667 0.0653
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Loa Loa (eye worm) hypothetical protein 0.005 0.1077 0.3882
Echinococcus multilocularis pyruvate kinase 0.0027 0.0492 0.0478
Loa Loa (eye worm) hypothetical protein 0.0034 0.0667 0.2387
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0936 0.0922
Echinococcus multilocularis dnaJ subfamily B 0.0414 1 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0168
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0416 0.1472
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0667 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0667 0.0653
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0936 0.0922
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0091 0.206 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0593 0.0578
Trypanosoma brucei Peptide deformylase 2 0.0091 0.206 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0091 0.206 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0936 0.0922
Plasmodium falciparum pyruvate kinase 0.0034 0.0667 0.0747
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Brugia malayi hypothetical protein 0.0035 0.0694 0.2487
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0667 0.0524
Leishmania major polypeptide deformylase-like protein, putative 0.0091 0.206 1
Plasmodium vivax peptide deformylase, putative 0.0237 0.5662 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.2753 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0694 0.068
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0237 0.5662 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0667 0.2387
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0667 0.2387
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0667 0.0747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0936 0.0922
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0667 0.2387
Loa Loa (eye worm) hypothetical protein 0.0024 0.0416 0.1472
Schistosoma mansoni hypothetical protein 0.0348 0.8391 0.8388
Brugia malayi CXXC zinc finger family protein 0.0029 0.0552 0.1966
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1077 0.3882
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0089 0.0278
Entamoeba histolytica hypothetical protein 0.0035 0.0694 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0685 0.2452
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0667 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.023 0.0793
Onchocerca volvulus Huntingtin homolog 0.0119 0.2753 1
Schistosoma mansoni hypothetical protein 0.0035 0.0694 0.068
Toxoplasma gondii hypothetical protein 0.0237 0.5662 1
Trypanosoma brucei Polypeptide deformylase 1 0.0091 0.206 1
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Echinococcus granulosus GPCR family 2 0.0016 0.023 0.0215
Giardia lamblia Pyruvate kinase 0.0034 0.0667 1
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0237 0.5662 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1352 0.1338
Loa Loa (eye worm) hypothetical protein 0.0119 0.2753 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.023 0.0793
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0552 0.1966
Schistosoma mansoni pyruvate kinase 0.0017 0.0264 0.0249
Onchocerca volvulus Huntingtin homolog 0.0119 0.2753 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0667 0.0524
Echinococcus granulosus pyruvate kinase 0.0017 0.0264 0.0249
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0936 0.3369
Schistosoma mansoni cpg binding protein 0.0031 0.0593 0.0578
Entamoeba histolytica hypothetical protein 0.0035 0.0694 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0667 0.0524
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0667 0.2387
Echinococcus multilocularis pyruvate kinase 0.0017 0.0264 0.0249
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1077 0.3882
Echinococcus granulosus pyruvate kinase 0.0017 0.0264 0.0249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0936 0.0922
Trypanosoma cruzi Peptide deformylase 2, putative 0.0091 0.206 1
Echinococcus multilocularis geminin 0.0348 0.8391 0.8388
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.023 0.0793
Echinococcus granulosus cpg binding protein 0.0031 0.0593 0.0578
Entamoeba histolytica hypothetical protein 0.0035 0.0694 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0694 0.068
Echinococcus granulosus pyruvate kinase 0.0017 0.0264 0.0249
Echinococcus granulosus geminin 0.0348 0.8391 0.8388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0936 0.0922
Echinococcus multilocularis pyruvate kinase 0.0017 0.0264 0.0249
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0936 0.3369
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0667 0.0747
Echinococcus multilocularis GPCR, family 2 0.0016 0.023 0.0215
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.023 0.0215
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0237 0.5662 1
Chlamydia trachomatis peptide deformylase 0.0237 0.5662 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0694 0.068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Brugia malayi hypothetical protein 0.0119 0.2753 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.119 0.1716
Schistosoma mansoni hypothetical protein 0.0414 1 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0667 0.0653
Mycobacterium ulcerans peptide deformylase 0.0237 0.5662 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0685 0.2452
Schistosoma mansoni hypothetical protein 0.0348 0.8391 0.8388
Echinococcus multilocularis pyruvate kinase 0.0034 0.0667 0.0653

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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