Detailed information for compound 690617

Basic information

Technical information
  • TDR Targets ID: 690617
  • Name: N'-(2,2-diethoxyethyl)-N-[2-furan-2-yl-2-(4-p henylpiperazin-1-yl)ethyl]oxamide
  • MW: 458.551 | Formula: C24H34N4O5
  • H donors: 2 H acceptors: 2 LogP: 2.11 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(CNC(=O)C(=O)NCC(c1ccco1)N1CCN(CC1)c1ccccc1)OCC
  • InChi: 1S/C24H34N4O5/c1-3-31-22(32-4-2)18-26-24(30)23(29)25-17-20(21-11-8-16-33-21)28-14-12-27(13-15-28)19-9-6-5-7-10-19/h5-11,16,20,22H,3-4,12-15,17-18H2,1-2H3,(H,25,29)(H,26,30)
  • InChiKey: CNJAOFRXCMGOAA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(2,2-diethoxyethyl)-N-[2-(2-furyl)-2-(4-phenylpiperazin-1-yl)ethyl]oxamide
  • N'-(2,2-diethoxyethyl)-N-[2-(2-furyl)-2-(4-phenyl-1-piperazinyl)ethyl]oxamide
  • N'-(2,2-diethoxyethyl)-N-[2-furan-2-yl-2-(4-phenylpiperazin-1-yl)ethyl]ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax peptide deformylase, putative 0.0237 0.5662 1
Giardia lamblia Pyruvate kinase 0.0034 0.0667 1
Plasmodium falciparum peptide deformylase 0.0237 0.5662 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.023 0.0215
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0667 0.2387
Trypanosoma brucei Polypeptide deformylase 1 0.0091 0.206 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.023 0.0793
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0552 0.1966
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0089 0.0278
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0056 0.0158
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0694 0.068
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0237 0.5662 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1352 0.1338
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Echinococcus granulosus GPCR family 2 0.0016 0.023 0.0215
Loa Loa (eye worm) hypothetical protein 0.0034 0.0667 0.2387
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.023 0.0793
Loa Loa (eye worm) hypothetical protein 0.0024 0.0416 0.1472
Onchocerca volvulus Huntingtin homolog 0.0119 0.2753 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1077 0.3882
Entamoeba histolytica hypothetical protein 0.0035 0.0694 1
Brugia malayi hypothetical protein 0.0035 0.0694 0.2487
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0667 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0685 0.2452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0936 0.0922
Loa Loa (eye worm) hypothetical protein 0.0119 0.2753 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0667 0.0524
Echinococcus multilocularis pyruvate kinase 0.0034 0.0667 0.0653
Echinococcus multilocularis dnaJ subfamily B 0.0414 1 1
Schistosoma mansoni cpg binding protein 0.0029 0.0552 0.0537
Schistosoma mansoni hypothetical protein 0.0035 0.0694 0.068
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0667 0.0747
Loa Loa (eye worm) hypothetical protein 0.0016 0.023 0.0793
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0936 0.0922
Brugia malayi hypothetical protein 0.0119 0.2753 1
Schistosoma mansoni cpg binding protein 0.0031 0.0593 0.0578
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0936 0.0922
Toxoplasma gondii hypothetical protein 0.0237 0.5662 1
Entamoeba histolytica hypothetical protein 0.0035 0.0694 1
Onchocerca volvulus Huntingtin homolog 0.0119 0.2753 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0264 0.0249
Echinococcus multilocularis pyruvate kinase 0.0027 0.0492 0.0478
Schistosoma mansoni cpg binding protein 0.0031 0.0593 0.0578
Loa Loa (eye worm) hypothetical protein 0.005 0.1077 0.3882
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0694 0.068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0685 0.2452
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Schistosoma mansoni pyruvate kinase 0.0017 0.0264 0.0249
Leishmania major polypeptide deformylase-like protein, putative 0.0091 0.206 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0091 0.206 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0264 0.0249
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.023 0.0215
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.119 0.1716
Entamoeba histolytica hypothetical protein 0.0035 0.0694 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0936 0.0922
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0667 0.2387
Echinococcus granulosus pyruvate kinase 0.0034 0.0667 0.0653
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0667 0.0524
Echinococcus granulosus pyruvate kinase 0.0017 0.0264 0.0249
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0667 0.2387
Echinococcus multilocularis pyruvate kinase 0.0017 0.0264 0.0249
Schistosoma mansoni hypothetical protein 0.0034 0.0685 0.067
Schistosoma mansoni hypothetical protein 0.0414 1 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0667 0.0653
Loa Loa (eye worm) hypothetical protein 0.0119 0.2753 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.023 0.0215
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0667 0.0747
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0168
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0936 0.3369
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0667 0.2387
Trypanosoma cruzi Peptide deformylase 2, putative 0.0091 0.206 1
Schistosoma mansoni hypothetical protein 0.0016 0.023 0.0215
Treponema pallidum polypeptide deformylase (def) 0.0237 0.5662 0.5
Echinococcus granulosus pyruvate kinase 0.0017 0.0264 0.0249
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0694 0.068
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0667 0.0524
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.023 0.0793
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0667 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0552 0.1966
Trypanosoma cruzi Peptide deformylase 2, putative 0.0091 0.206 1
Echinococcus multilocularis geminin 0.0348 0.8391 0.8388
Schistosoma mansoni hypothetical protein 0.0348 0.8391 0.8388
Plasmodium falciparum pyruvate kinase 0.0034 0.0667 0.0747
Mycobacterium ulcerans peptide deformylase 0.0237 0.5662 1
Echinococcus granulosus cpg binding protein 0.0031 0.0593 0.0578
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0667 0.2387
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0936 0.3369
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0091 0.206 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0936 0.0922
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0936 0.0922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0936 0.0922
Echinococcus multilocularis GPCR, family 2 0.0016 0.023 0.0215
Entamoeba histolytica hypothetical protein 0.0035 0.0694 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1077 0.3882
Echinococcus multilocularis pyruvate kinase 0.0034 0.0667 0.0653
Chlamydia trachomatis peptide deformylase 0.0237 0.5662 1
Echinococcus granulosus geminin 0.0348 0.8391 0.8388
Schistosoma mansoni hypothetical protein 0.0348 0.8391 0.8388
Trypanosoma brucei Peptide deformylase 2 0.0091 0.206 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.023 0.0215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1077 0.3882
Echinococcus multilocularis cpg binding protein 0.0031 0.0593 0.0578
Schistosoma mansoni pyruvate kinase 0.0034 0.0667 0.0653
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0237 0.5662 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0416 0.1472
Echinococcus multilocularis pyruvate kinase 0.0017 0.0264 0.0249
Schistosoma mansoni pyruvate kinase 0.0034 0.0667 0.0653
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0237 0.5662 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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