Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0061 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0158 | 0.3931 | 0.5818 |
Leishmania major | protein kinase, putative | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0227 | 0.6756 | 1 |
Leishmania major | protein kinase, putative | 0.0061 | 0 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0307 | 1 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0158 | 0.3931 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0307 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0165 | 0.4247 | 0.6286 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0061 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0307 | 1 | 0.5 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0227 | 0.6756 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0307 | 1 | 0.5 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0061 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0227 | 0.6756 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0165 | 0.4247 | 0.6286 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0158 | 0.3931 | 0.5818 |
Giardia lamblia | Kinase, CMGC CLK | 0.0061 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0 | 0.5 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0227 | 0.6756 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0061 | 0 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0307 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0158 | 0.3931 | 0.5818 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0158 | 0.3931 | 0.5818 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0061 | 0 | 0.5 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0061 | 0 | 0.5 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0158 | 0.3931 | 0.5818 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0158 | 0.3931 | 0.5818 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 0.4247 | 0.6286 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0307 | 1 | 1 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0227 | 0.6756 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0307 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0158 | 0.3931 | 0.5818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.