Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0246 | 0.0739 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0014 | 0.0043 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0246 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.3217 | 0.965 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0246 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3333 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0246 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0246 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.003 | 0.0687 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.1046 | 0.3137 |
Loa Loa (eye worm) | TAR-binding protein | 0.0135 | 0.3333 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0568 | 0.1705 |
Echinococcus granulosus | tar DNA binding protein | 0.0135 | 0.3333 | 0.3333 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1058 | 0.3174 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.3217 | 0.965 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.006 | 0.0181 |
Brugia malayi | TAR-binding protein | 0.0135 | 0.3333 | 1 |
Schistosoma mansoni | ferritin light chain | 0.0018 | 0.0014 | 0.0043 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0246 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.003 | 0.0687 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1058 | 0.3174 |
Schistosoma mansoni | apoferritin-2 | 0.0018 | 0.0014 | 0.0043 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1046 | 0.3137 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.006 | 0.0181 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1058 | 0.3174 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.003 | 0.0687 |
Schistosoma mansoni | ferritin light chain | 0.0018 | 0.0014 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.006 | 0.0181 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0246 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0018 | 0.0014 | 0.5 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0014 | 0.0043 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3333 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.006 | 0.1981 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0014 | 0.0043 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0246 | 1 |
Onchocerca volvulus | 0.0054 | 0.1046 | 1 | |
Echinococcus multilocularis | tumor protein p63 | 0.037 | 1 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.0018 | 0.0014 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.006 | 0.1981 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3333 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0246 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0246 | 1 |
Echinococcus multilocularis | ferritin | 0.0018 | 0.0014 | 0.0014 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.006 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0018 | 0.0014 | 0.0014 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0246 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0246 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0135 | 0.3333 | 0.3333 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0246 | 0.0739 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0246 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0135 | 0.3333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0246 | 0.0739 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.006 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0246 | 1 |
Schistosoma mansoni | ferritin | 0.0018 | 0.0014 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0246 | 0.0739 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3333 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0135 | 0.3333 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0246 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0135 | 0.3333 | 1 |
Echinococcus granulosus | ferritin | 0.0018 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0568 | 0.1705 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.006 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0246 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0246 | 0.0739 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.3217 | 0.965 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.006 | 0.0181 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3333 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0018 | 0.0014 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1058 | 0.3174 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0246 | 0.0739 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.003 | 0.0687 |
Echinococcus multilocularis | expressed protein | 0.0018 | 0.0014 | 0.0014 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0568 | 0.1705 |
Brugia malayi | RNA binding protein | 0.0135 | 0.3333 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0018 | 0.0014 | 0.0043 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.006 | 0.0181 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.