Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.2195 | 0.722 | 0.7077 |
Echinococcus granulosus | acetylcholinesterase | 0.2195 | 0.722 | 0.7077 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0371 | 0.0491 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0371 | 0.0491 | 0.0491 |
Brugia malayi | Carboxylesterase family protein | 0.2195 | 0.722 | 0.7077 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.0439 | 0.0741 | 0.0263 |
Echinococcus granulosus | carboxylesterase 5A | 0.2195 | 0.722 | 0.7077 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0371 | 0.0491 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2195 | 0.722 | 0.7077 |
Onchocerca volvulus | 0.0371 | 0.0491 | 0.5 | |
Onchocerca volvulus | 0.0371 | 0.0491 | 0.5 | |
Onchocerca volvulus | 0.0371 | 0.0491 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2195 | 0.722 | 0.7077 |
Loa Loa (eye worm) | hypothetical protein | 0.2195 | 0.722 | 0.7077 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.2948 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0371 | 0.0491 | 0.0491 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2195 | 0.722 | 0.722 |
Loa Loa (eye worm) | hypothetical protein | 0.2948 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2195 | 0.722 | 0.7077 |
Echinococcus multilocularis | acetylcholinesterase | 0.2195 | 0.722 | 0.7077 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0371 | 0.0491 | 0.0491 |
Onchocerca volvulus | 0.0371 | 0.0491 | 0.5 | |
Echinococcus granulosus | stromal interaction molecule 1 | 0.0439 | 0.0741 | 0.0263 |
Brugia malayi | hypothetical protein | 0.0439 | 0.0741 | 0.0263 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0371 | 0.0491 | 0.0491 |
Echinococcus granulosus | calcium release activated calcium channel | 0.2948 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2195 | 0.722 | 0.7077 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0371 | 0.0491 | 0.0491 |
Schistosoma mansoni | Protein orai-1 | 0.2948 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0371 | 0.0491 | 0.5 |
Onchocerca volvulus | 0.0371 | 0.0491 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.0741 | 0.0263 |
Schistosoma mansoni | acetylcholinesterase | 0.0371 | 0.0491 | 0.0491 |
Schistosoma mansoni | Protein orai-1 | 0.2948 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2195 | 0.722 | 0.7077 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2195 | 0.722 | 0.7077 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0371 | 0.0491 | 0.0491 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0371 | 0.0491 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0371 | 0.0491 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0371 | 0.0491 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC25 (functional) | = 7.7 | Negative inotropy measured as the concentration required to depress contraction in the isolated Langendorff-perfused guinea pig heart by 25% | ChEMBL. | 2943898 |
-Log IC50 (functional) | = 7.9 | In vitro calcium antagonist activity was assessed against calcium induced constriction of potassium-depolarized rat aorta | ChEMBL. | 2943898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.