TDR Targets

Basic information

Technical information

TDR Targets ID: 697958
Name: 2-[6-(4-fluorophenyl)-4,7,8-trimethyl-1,3-dio xopurino[7,8-a]imidazol-2-yl]acetamide
MW: 384.364 | Formula: C18H17FN6O3
H donors: 1 H acceptors: 4 LogP: 1.98 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)Cn1c(=O)n(C)c2c(c1=O)n1c(n2)n(c(c1C)C)c1ccc(cc1)F
InChi: 1S/C18H17FN6O3/c1-9-10(2)25-14-15(22(3)18(28)23(16(14)27)8-13(20)26)21-17(25)24(9)12-6-4-11(19)5-7-12/h4-7H,8H2,1-3H3,(H2,20,26)
InChiKey: DARWTKCCWUJPLF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[6-(4-fluorophenyl)-4,7,8-trimethyl-1,3-dioxo-purino[7,8-a]imidazol-2-yl]acetamide
2-[6-(4-fluorophenyl)-4,7,8-trimethyl-1,3-dioxo-2-purino[7,8-a]imidazolyl]acetamide
2-[6-(4-fluorophenyl)-1,3-diketo-4,7,8-trimethyl-purino[7,8-a]imidazol-2-yl]acetamide
2-[6-(4-fluorophenyl)-4,7,8-trimethyl-1,3-dioxo-purino[7,8-a]imidazol-2-yl]ethanamide
BAS 12662495

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.395
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0021	0.0256	0.0829
Mycobacterium ulcerans	sugar transporter	0.0014	0.0084	0.2954
Onchocerca volvulus		0.0021	0.0256	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0021	0.0256	0.0829
Brugia malayi	Dopamine receptor protein 2	0.0021	0.0256	0.0829
Echinococcus multilocularis	neuropeptide s receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0049	0.0903	0.3945
Schistosoma mansoni	hypothetical protein	0.0021	0.0256	0.0829
Echinococcus granulosus	7tm_1 domain containing protein	0.0021	0.0256	0.0829
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0493	0.1973
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0016	0.013	0.0418
Echinococcus granulosus	allatostatin A receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.216	1
Brugia malayi	G-protein coupled receptor	0.0021	0.0256	0.0829
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0484	0.1927
Entamoeba histolytica	protein kinase, putative	0.0031	0.0484	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0484	0.2088
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0256	0.0829
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0493	0.8107
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0484	0.2088
Loa Loa (eye worm)	hypothetical protein	0.003	0.0469	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0903	0.4066
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0484	0.0404
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0256	0.0829
Schistosoma mansoni	hypothetical protein	0.0016	0.013	0.0224
Onchocerca volvulus		0.0021	0.0256	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.0256	0.1011
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0589	1
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.216	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0021	0.0256	0.0829
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0256	0.0829
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0469	0.1855
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.0256	0.1011
Schistosoma mansoni	metabotropic glutamate receptor	0.0033	0.0533	0.2162
Brugia malayi	Sugar transporter family protein	0.0101	0.216	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.0256	0.0829
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0256	0.0829
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.216	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0256	0.0829
Brugia malayi	G protein-coupled receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0256	0.0829
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.013	0.0418
Entamoeba histolytica	protein kinase, putative	0.0031	0.0484	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.0469	0.1855
Schistosoma mansoni	hypothetical protein	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Schistosoma mansoni	protein kinase	0.0031	0.0484	0.1927
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0256	0.0829
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.216	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.395
Loa Loa (eye worm)	glutamate receptor	0.0015	0.0114	0.0344
Echinococcus granulosus	g-protein coupled receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus granulosus	sex peptide receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	somatostatin receptor	0.0021	0.0256	0.0829
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0484	0.0617
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0084	0.0199
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.013	0.0224
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Trypanosoma brucei	glucose transporter 1E	0.0031	0.0493	0.8107
Plasmodium vivax	hexose transporter	0.0101	0.216	0.2094
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0484	0.1927
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.0469	1
Schistosoma mansoni	opsin-like receptor	0.0021	0.0256	0.0829
Leishmania major	glucose transporter, lmgt2	0.0031	0.0493	0.8107
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0154	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.216	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.216	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0484	0.0404
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0589	1
Brugia malayi	sulfakinin receptor protein	0.0021	0.0256	0.0829
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0036	0.0597	0.2471
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Echinococcus granulosus	dro:myosuppressin receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0021	0.0256	0.0829
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.0256	0.0829
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0035	0.0589	0.0779
Toxoplasma gondii	protein kinase, putative	0.0286	0.6571	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0101	0.216	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.0256	0.0829
Plasmodium vivax	proline--tRNA ligase, putative	0.0035	0.0589	0.051
Schistosoma mansoni	protein kinase	0.0031	0.0484	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus multilocularis	serotonin receptor	0.0021	0.0256	0.0829
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Echinococcus multilocularis	allatostatin A receptor	0.0021	0.0256	0.0829
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0484	0.0617
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0256	0.0829
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0493	0.1973
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.216	1
Schistosoma mansoni	amine GPCR	0.0021	0.0256	0.0829
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0045	0.0814	0.3519
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.0961
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	sugar transporter	0.0014	0.0084	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Brugia malayi	ORL1-like opioid receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Schistosoma mansoni	hypothetical protein	0.0016	0.013	0.0224
Onchocerca volvulus		0.0021	0.0256	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0021	0.0256	0.0829
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Brugia malayi	Cam kinase protein 1	0.0031	0.0484	0.1927
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Schistosoma mansoni	glucose transport protein	0.0101	0.216	1
Leishmania major	protein kinase, putative	0.0031	0.0484	0.7919
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Plasmodium falciparum	proline--tRNA ligase	0.0035	0.0589	0.051
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Schistosoma mansoni	hypothetical protein	0.0016	0.013	0.0224
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Schistosoma mansoni	amine GPCR	0.0021	0.0256	0.0829
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.013	0.0224
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0256	0.0829
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0283	0.0961
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.0469	1
Schistosoma mansoni	adenoreceptor	0.0021	0.0256	0.0829
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Echinococcus multilocularis	dro:myosuppressin receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Brugia malayi	RE15519p	0.0021	0.0256	0.0829
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0283	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Schistosoma mansoni	opsin-like receptor	0.0021	0.0256	0.0829
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.013	0.0224
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0493	0.1973
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0283	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0493	0.1973
Schistosoma mansoni	metabotropic glutamate receptor	0.0019	0.0203	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0256	0.0829
Brugia malayi	Melatonin receptor type 1A	0.0021	0.0256	0.0829
Trypanosoma cruzi	hexose transporter	0.0031	0.0493	0.8107
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0256	0.0829
Echinococcus multilocularis	neuropeptide receptor A26	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0283	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Schistosoma mansoni	protein kinase	0.0031	0.0484	0.1927
Onchocerca volvulus		0.0021	0.0256	1
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.003	0.0469	0.2017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0256	0.0829
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0589	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.216	1
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	amine GPCR	0.0021	0.0256	0.0829
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.013	0.0224
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.0256	0.1011
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0256	0.0829
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Onchocerca volvulus		0.0021	0.0256	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0484	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.0961
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0256	0.1011
Schistosoma mansoni	hypothetical protein	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0256	0.0829
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.0469	0.1855
Brugia malayi	Serotonin receptor	0.0021	0.0256	0.0829
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.0256	0.0829
Echinococcus granulosus	neuropeptide receptor A26	0.0021	0.0256	0.0829
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0438	0.1707
Echinococcus multilocularis	serotonin receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0256	0.0829
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0039	0.0685	0.2898
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Schistosoma mansoni	histamine h1 receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus multilocularis	sex peptide receptor	0.0021	0.0256	0.0829
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.0256	0.1011
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0578	0.2533
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.0469	0.9253
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0484	0.0404
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.0256	0.1011
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.0469	0.1855
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0049	0.0903	0.3945
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Schistosoma mansoni	opsin-like receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0084	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Schistosoma mansoni	hypothetical protein	0.0021	0.0256	0.0829
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0589	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0484	0.0617
Loa Loa (eye worm)	glutamate receptor	0.0039	0.0685	0.3039
Brugia malayi	Serotonin receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.013	0.0224
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0469	0.1855
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0283	0.5182
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0256	0.0829
Leishmania major	glucose transporter, lmgt3	0.0031	0.0493	0.8107
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Brugia malayi	AKH receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0256	0.0829
Plasmodium falciparum	hexose transporter	0.0101	0.216	0.2094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0256	0.0829
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0256	0.0829
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0031	0.0493	0.8107
Schistosoma mansoni	hypothetical protein	0.0035	0.0578	0.2382
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0033	0.0533	0.2162
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0163	0.3649	0.5495
Trypanosoma brucei	glucose transporter 2A	0.0031	0.0493	0.8107
Echinococcus granulosus	neuropeptide FF receptor 2	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0283	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Brugia malayi	GnHR receptor homolog	0.0021	0.0256	0.0829
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0484	0.0404
Echinococcus granulosus	neuropeptide s receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Brugia malayi	neuropeptide F receptor	0.0021	0.0256	0.0829
Plasmodium falciparum	protein kinase 7	0.0286	0.6571	0.6542
Brugia malayi	larval opioid receptor	0.0021	0.0256	0.0829
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0493	0.1973
Brugia malayi	Dopamine receptor	0.0021	0.0256	0.0829
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0283	0.0201
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0084	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0084	0.0199
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0589	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0021	0.0256	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0101	0.216	0.3201
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Echinococcus multilocularis	orexin receptor type 2	0.0021	0.0256	0.0829
Echinococcus granulosus	General substrate transporter	0.0087	0.1821	0.8364
Schistosoma mansoni	myosin xvIII	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0163	0.3649	0.3595
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0964	0.4241
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.0256	0.0829
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0484	0.0404
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0256	0.0829
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0202	1
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.395
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0256	0.0829
Schistosoma mansoni	glucose transport protein	0.0101	0.216	1
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	7TM GPCR rhodopsin	0.0021	0.0256	0.0829
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.013	0.0224
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.0469	0.1855
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0283	0.0961
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0438	0.1707
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Echinococcus granulosus	GPCR family 2	0.0016	0.013	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	amine GPCR	0.0021	0.0256	0.0829
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0484	0.1927
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0484	0.7919
Brugia malayi	G-protein coupled receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Brugia malayi	neuropeptide F receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.0469	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0283	0.0961
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0256	0.0829
Echinococcus granulosus	orexin receptor type 2	0.0021	0.0256	0.0829
Echinococcus granulosus	G protein coupled receptor 139	0.0021	0.0256	0.0829
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0256	0.0829
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0578	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0033	0.0533	0.2162
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Schistosoma mansoni	amine GPCR	0.0021	0.0256	0.0829
Schistosoma mansoni	hypothetical protein	0.0016	0.013	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0084	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0964	0.4356
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0283	0.3046
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0493	0.1973
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.0256	0.0829
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0256	0.0829
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0964	0.4241
Echinococcus multilocularis	G protein coupled receptor 139	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0493	0.1973
Echinococcus granulosus	fmrfamide receptor	0.0021	0.0256	0.0829
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0484	0.0404
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0484	0.0404
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0484	0.0404
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Brugia malayi	metabotropic glutamate receptor type 2	0.0019	0.0203	0.0574
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0493	0.8107
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0021	0.0256	0.0829
Onchocerca volvulus		0.0021	0.0256	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.0256	0.0829
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Schistosoma mansoni	hypothetical protein	0.0101	0.216	1
Echinococcus multilocularis	g-protein coupled receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0256	0.1011
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.0256	0.0829
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0256	0.0829
Leishmania major	glucose transporter, lmgt1	0.0031	0.0493	0.8107
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0256	0.0829
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0493	0.8107
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0256	0.0829
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0256	0.0829
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0484	0.0404
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0202	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0021	0.0256	0.0829
Echinococcus multilocularis	somatostatin receptor	0.0021	0.0256	0.0829
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0163	0.3649	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0961
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0217	0.0641
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0021	0.0256	0.0829
Brugia malayi	Dopamine receptor protein 1	0.0021	0.0256	0.0829
Echinococcus granulosus	serotonin receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0256	0.0829
Brugia malayi	putative neuropeptide receptor	0.0021	0.0256	0.0829
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0084	0.2954
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0021	0.0256	0.0829
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0484	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0333	0.1375
Echinococcus granulosus	hypothetical protein	0.0021	0.0256	0.0829
Brugia malayi	hypothetical protein	0.0021	0.0256	0.0829
Schistosoma mansoni	glucose transport protein	0.0101	0.216	1
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0256	0.1011
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0256	0.1011
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0256	0.0829
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Echinococcus multilocularis	General substrate transporter	0.0087	0.1821	0.8364
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0021	0.0256	0.0829
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0256	0.0829
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0256	0.1011
Loa Loa (eye worm)	sugar transporter	0.0101	0.216	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.013	0.0224
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.0256	0.1011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0256	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0964	0.4356
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0256	0.0829
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0256	0.0829
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0429	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0021	0.0256	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 697958