Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.473 | 0.6594 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0944 | 0.1316 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0854 | 0.1353 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0133 | 0.5169 | 0.7206 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0944 | 0.1495 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0944 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0944 | 0.1316 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0001 | 0.0002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1591 | 0.2518 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0944 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0944 | 0.1316 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0944 | 0.1495 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0001 | 0.0002 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.0944 | 0.0943 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0944 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.5169 | 0.7206 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0944 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.473 | 0.6594 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0944 | 0.0943 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0944 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1591 | 0.2518 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.4836 | 0.7656 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0944 | 0.1495 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.7173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0944 | 0.1495 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0944 | 0.1495 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0944 | 0.5 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.0944 | 0.0943 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0944 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0944 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0001 | 0.0002 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0944 | 0.0943 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.4836 | 0.7656 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0944 | 0.1495 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0854 | 0.1353 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0001 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.473 | 0.6594 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0001 | 0.0002 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0944 | 0.0943 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0944 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0944 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0944 | 0.1495 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0001 | 0.0002 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0944 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.0944 | 0.0943 |
Brugia malayi | hypothetical protein | 0.0159 | 0.6317 | 1 |
Echinococcus multilocularis | geminin | 0.0178 | 0.7173 | 1 |
Echinococcus granulosus | geminin | 0.0178 | 0.7173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0944 | 0.1495 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0001 | 0.0002 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0944 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.0944 | 0.0943 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0944 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1591 | 0.2518 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0944 | 0.1495 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0944 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0944 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0944 | 0.5 |
Onchocerca volvulus | 0.0159 | 0.6317 | 1 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0944 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0944 | 0.1495 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.7173 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.4836 | 0.7656 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0001 | 0.0002 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.0944 | 0.0943 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0944 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0854 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.6317 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0944 | 0.1495 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0944 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0944 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0001 | 0.0002 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.5169 | 0.7206 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.0944 | 0.0943 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0944 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1591 | 0.2518 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.0944 | 0.0943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.