Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nephrin | 0.0253 | 0.379 | 1 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0157 | 0 | 0.5 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0193 | 0.1427 | 0.3765 |
Echinococcus granulosus | nephrin | 0.0253 | 0.379 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0253 | 0.379 | 0.6803 |
Echinococcus multilocularis | Immunoglobulin | 0.0253 | 0.379 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0253 | 0.379 | 0.6803 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.5571 | 1 |
Echinococcus granulosus | irregular chiasm roughest protein | 0.0253 | 0.379 | 1 |
Echinococcus granulosus | Immunoglobulin | 0.0253 | 0.379 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0253 | 0.379 | 1 |
Echinococcus granulosus | nephrin | 0.0253 | 0.379 | 1 |
Echinococcus multilocularis | irregular chiasm roughest protein immunoglobulin set domain containing protein | 0.0253 | 0.379 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0323 | 0.658 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0323 | 0.658 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0193 | 0.1427 | 0.3765 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 10 mg kg-1 | Antagonistic activity against apomorphine induced climbing in CD-1 mice, after oral administration | ChEMBL. | 6644744 |
ED50 (functional) | > 10 mg kg-1 | Antagonistic activity against apomorphine induced climbing in CD-1 mice, after oral administration | ChEMBL. | 6644744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.