Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0325 | 0.031 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0521 | 0.3992 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1257 | 1 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.0325 | 0.2456 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0521 | 0.3992 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.0746 | 0.964 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0126 | 0.0767 | 0.1537 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0126 | 0.0767 | 0.1537 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0497 | 0.38 | 0.4636 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0072 | 0.0329 | 0.0315 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.0255 | 0.1273 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0092 | 0.0493 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0493 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0521 | 0.3992 | 0.3983 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0092 | 0.0493 | 0.5323 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0092 | 0.0493 | 0.1234 |
Leishmania major | carbonic anhydrase-like protein | 0.0126 | 0.0767 | 0.1205 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0493 | 0.0478 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1003 | 0.7926 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0493 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0325 | 0.031 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0072 | 0.0329 | 0.254 |
Brugia malayi | Probable ClpP-like protease | 0.0092 | 0.0493 | 0.5323 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0126 | 0.0767 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0126 | 0.0767 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.0746 | 0.964 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0267 | 0.1918 | 0.219 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0072 | 0.0329 | 0.254 |
Schistosoma mansoni | carbonic anhydrase | 0.0521 | 0.3992 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0126 | 0.0767 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0126 | 0.0767 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0072 | 0.0329 | 0.0125 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0072 | 0.0329 | 0.254 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.0325 | 0.659 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0493 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0521 | 0.3992 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0092 | 0.0493 | 0.0818 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0325 | 0.0378 |
Echinococcus granulosus | peptidase Clp S14 family | 0.006 | 0.0234 | 0.0905 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0325 | 0.031 |
Onchocerca volvulus | Putative sulfate transporter | 0.0211 | 0.146 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.006 | 0.0234 | 0.0585 |
Echinococcus granulosus | carbonic anhydrase II | 0.0126 | 0.0767 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0072 | 0.0329 | 0.0315 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0072 | 0.0329 | 0.0013 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0243 | 0.1726 | 0.194 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0126 | 0.0767 | 1 |
Plasmodium vivax | sulfate transporter, putative | 0.0034 | 0.0015 | 0.0301 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.006 | 0.0234 | 0.0905 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0126 | 0.0767 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.0746 | 0.964 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0493 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0126 | 0.0767 | 1 |
Toxoplasma gondii | inorganic anion transporter, sulfate permease (SulP) family protein | 0.0034 | 0.0015 | 0.0301 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0072 | 0.0329 | 0.039 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0092 | 0.0493 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0092 | 0.0493 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1257 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0325 | 0.0378 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0092 | 0.0493 | 0.5323 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.0325 | 0.0118 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0493 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0126 | 0.0767 | 1 |
Onchocerca volvulus | 0.0211 | 0.146 | 0.5 | |
Plasmodium falciparum | inorganic anion exchanger, inorganic anion antiporter | 0.0034 | 0.0015 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0493 | 0.5323 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 0.0493 | 0.0478 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.0325 | 0.2456 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0243 | 0.1726 | 0.4324 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils; ND=No data | ChEMBL. | 2415706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.