Detailed information for compound 705428

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.466 | Formula: C22H27N3O6
  • H donors: 1 H acceptors: 3 LogP: 1.05 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)Cn1cc(OC)c(=O)cc1CN1CCOCC1
  • InChi: 1S/C22H27N3O6/c1-3-31-22(28)16-4-6-17(7-5-16)23-21(27)15-25-14-20(29-2)19(26)12-18(25)13-24-8-10-30-11-9-24/h4-7,12,14H,3,8-11,13,15H2,1-2H3,(H,23,27)
  • InChiKey: BNPLIJMSNRPJND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus caspase 2 0.0058 0.1093 0.4574
Schistosoma mansoni glucose transport protein 0.0102 0.2125 0.907
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0455 0.0414
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0414 0.057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Leishmania major glucose transporter, lmgt1 0.0032 0.0453 0.1789
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0952 0.396
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0414 1
Trypanosoma brucei glucose transporter 2A 0.0032 0.0453 0.1789
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.1619
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.012 0.0336
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0455 0.0633
Loa Loa (eye worm) hypothetical protein 0.0041 0.0675 0.2885
Trypanosoma brucei glucose transporter, putative 0.0032 0.0453 0.1789
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0952 0.4069
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0453 0.1789
Plasmodium vivax metacaspase 1, putative 0.0018 0.012 0.0078
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0414 0.057
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0429 0.1682
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0243 0.0374
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0575 0.2317
Brugia malayi hypothetical protein 0.0041 0.0675 0.2754
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0675 0.2754
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0455 0.1795
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0429 0.1682
Echinococcus granulosus caspase 8 0.0018 0.012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0414 1
Trypanosoma cruzi hexose transporter 0.0032 0.0453 0.1789
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0824 0.3404
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0414 0.0818
Schistosoma mansoni hypothetical protein 0.0041 0.0675 0.2754
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0243 0.0201
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0453 0.1789
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2339 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0243 0.0872
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.012 0.0336
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0398 0.1548
Trypanosoma brucei glucose transporter, putative 0.0032 0.0453 0.1789
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0455 0.0414
Trypanosoma brucei metacaspase MCA3 0.0018 0.012 0.0336
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3629 0.3602
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0455 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0824 0.3404
Trypanosoma brucei glucose transporter 1E 0.0032 0.0453 0.1789
Trypanosoma brucei metacaspase 5, putative 0.0018 0.012 0.0336
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0952 0.396
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0042 0.0181
Brugia malayi hypothetical protein 0.0037 0.0575 0.2317
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0824 0.3404
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.2339 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0429 0.1682
Plasmodium falciparum metacaspase 1 0.0018 0.012 0.0078
Echinococcus granulosus caspase 0.0018 0.012 0.0336
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.2339 1
Echinococcus multilocularis caspase 0.0018 0.012 0.0336
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0042 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.1833
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 1 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0243 0.0872
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2339 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0243 0.0872
Loa Loa (eye worm) hypothetical protein 0.0025 0.0292 0.125
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.2339 1
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0952 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.2339 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0243 0.1037
Echinococcus multilocularis caspase 8 0.0018 0.012 0.0336
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.012 0.0336
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.012 0.0336
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0549 0.2207
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0453 0.1789
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0455 0.1795
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0455 0.1795
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0453 0.1789
Schistosoma mansoni glucose transport protein 0.0102 0.2125 0.907
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2125 0.907
Trypanosoma brucei protein kinase, putative 0.0053 0.0952 0.396
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0455 0.0414
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0243 0.0872
Schistosoma mansoni protein kinase 0.0032 0.0455 0.1795
Loa Loa (eye worm) sugar transporter 0.0102 0.2125 0.9086
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.012 0.0336
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0575 0.2317
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0455 0.1795
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0952 0.396
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.012 0.0336
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0453 0.1789
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2125 0.907
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0824 0.3404
Echinococcus multilocularis General substrate transporter 0.0088 0.1785 0.7586
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0243 0.0872
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3629 0.5503
Brugia malayi Cam kinase protein 1 0.0032 0.0455 0.1795
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Brugia malayi phosphofructokinase 0.0111 0.2339 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0952 0.396
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0176 0.0581
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0414 0.0373
Trypanosoma brucei glucose transporter, putative 0.0032 0.0453 0.1789
Trypanosoma brucei metacaspase 0.0018 0.012 0.0336
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2125 0.907
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0824 0.3404
Plasmodium falciparum protein kinase 7 0.0288 0.6561 0.6546
Brugia malayi MAP kinase sur-1 0.0053 0.0952 0.396
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0429 0.4249
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0243 0.0201
Entamoeba histolytica protein kinase, putative 0.0032 0.0455 0.1012
Leishmania major glucose transporter, lmgt3 0.0032 0.0453 0.1789
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0453 0.1789
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0243 0.2202
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0243 0.0872
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.2339 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0455 0.0633
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.1619
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0575 0.2317
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3629 0.3602
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.2339 1
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0952 0.396
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.1833
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2339 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0455 0.0633
Schistosoma mansoni protein kinase 0.0032 0.0455 0.1795
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.012 0.0336
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0549 0.2207
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0414 0.0373
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0243 0.0872
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0455 0.1795
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2125 0.907
Trypanosoma cruzi metacaspase, putative 0.0018 0.012 0.0336
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0455 0.0414
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.012 0.0336
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0952 0.396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0824 0.3404
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0824 0.3524
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2339 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.012 0.0336
Schistosoma mansoni protein kinase 0.0032 0.0455 0.1795
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.012 0.0119
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0455 0.1795
Leishmania major protein kinase, putative 0.0032 0.0455 0.1795
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0414 0.4088
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.1619
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0549 0.2207
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0549 0.2207
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0429 0.1682
Entamoeba histolytica hypothetical protein 0.0037 0.0575 0.1583
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0455 0.0414
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0455 0.0414
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0549 0.2207
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0161 0.0517
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.012 0.0336
Trypanosoma brucei glucose transporter, putative 0.0032 0.0453 0.1789
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0453 0.1789
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0455 0.1795
Loa Loa (eye worm) hypothetical protein 0.0058 0.1093 0.4673
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.012 0.0336
Trypanosoma cruzi metacaspase, putative 0.0018 0.012 0.0336
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0429 0.1682
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.012 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0453 0.1789
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0243 0.0872
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Loa Loa (eye worm) sugar transporter 0.0014 0.0042 0.0181
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0429 0.1682
Trypanosoma brucei metacaspase MCA2 0.0018 0.012 0.0336
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.1093 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0453 0.1789
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.1093 0.4574
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.1619
Brugia malayi Cell death protein 3 precursor 0.0058 0.1093 0.4574
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2339 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2125 0.907
Loa Loa (eye worm) hypothetical protein 0.0032 0.0455 0.1944
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0453 0.1789
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0824 0.3404
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.012 0.0119
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0453 0.1789
Trypanosoma brucei glucose transporter, putative 0.0032 0.0453 0.1789
Trypanosoma cruzi metacaspase, putative 0.0018 0.012 0.0336
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0243 0.0872
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0952 0.396
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0414 0.057
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0952 0.396
Trypanosoma brucei glucose transporter, putative 0.0032 0.0453 0.1789
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0018 0.012 0.0336
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0042 0.0181
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0455 0.1795
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2125 0.907
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0414 0.1619
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.1619
Plasmodium vivax hypothetical protein, conserved 0.0018 0.012 0.0078
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0161 0.0517
Plasmodium falciparum hexose transporter 0.0102 0.2125 0.2092
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.012 0.0336
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0455 0.1795
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.012 0.0336
Entamoeba histolytica protein kinase, putative 0.0032 0.0455 0.1012
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0952 0.1395
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2125 0.907
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0455 0.1795
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0824 0.3404
Entamoeba histolytica hypothetical protein 0.0037 0.0575 0.1583
Schistosoma mansoni hypothetical protein 0.0037 0.0575 0.2317
Entamoeba histolytica hypothetical protein 0.0037 0.0575 0.1583
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0549 0.0509
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0675 0.2754
Onchocerca volvulus 0.0041 0.0675 0.6021
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0952 0.396
Brugia malayi 6-phosphofructokinase 0.0111 0.2339 1
Schistosoma mansoni caspase-3 (C14 family) 0.0018 0.012 0.0336
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0429 0.0888
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0453 0.1789
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Plasmodium vivax hexose transporter 0.0102 0.2125 0.2092
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0243 0.0307
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.012 0.0336
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0112 0.0305
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0429 0.1682
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0455 0.1944
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0455 0.1944
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0455 0.0414
Echinococcus granulosus General substrate transporter 0.0088 0.1785 0.7586
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0455 0.1795
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2339 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.012 0.0336
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0549 0.0509
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2339 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2125 0.907
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Trypanosoma brucei Metacaspase-4 0.0018 0.012 0.0336
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0429 0.1229
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0455 0.1795
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0455 0.0414
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.012 0.0119
Plasmodium falciparum metacaspase-like protein 0.0018 0.012 0.0078
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0453 0.1789
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0243 0.0872
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0952 0.396
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0952 0.396
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2339 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0952 0.396
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0453 0.1789
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.012 0.0336
Entamoeba histolytica hypothetical protein 0.0037 0.0575 0.1583
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0952 0.396
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0453 0.1789
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0414 0.0373
Leishmania major metacaspase, putative 0.0018 0.012 0.0336
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0952 0.396
Leishmania major glucose transporter, lmgt2 0.0032 0.0453 0.1789
Brugia malayi 6-phosphofructokinase 0.0111 0.2339 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0018 0.012 0.0336
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0181
Trypanosoma brucei glucose transporter, putative 0.0032 0.0453 0.1789
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2125 0.907
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0511
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0414 0.1619
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2339 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0549 0.0778
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0952 0.396
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.012 0.0336
Echinococcus multilocularis caspase 2 0.0058 0.1093 0.4574
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2125 0.3196
Loa Loa (eye worm) phosphofructokinase 0.0111 0.2339 1
Toxoplasma gondii protein kinase, putative 0.0288 0.6561 1
Brugia malayi Sugar transporter family protein 0.0102 0.2125 0.907
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0243 0.0872
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0398 0.1548
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0414 0.0373
Schistosoma mansoni glucose transport protein 0.0102 0.2125 0.907
Trypanosoma cruzi metacaspase, putative 0.0018 0.012 0.0336
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0952 0.396
Schistosoma mansoni hypothetical protein 0.0102 0.2125 0.907
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2339 1
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2339 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.012 0.0336

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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