Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0072 | 0.0051 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0149 | 0.1077 | 0.0622 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0073 | 0.1112 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0076 | 0.0486 | 0.5 |
Echinococcus granulosus | geminin | 0.018 | 0.133 | 0.0887 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0073 | 0.1112 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0076 | 0.0486 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0073 | 0.1112 |
Brugia malayi | Muscleblind-like protein | 0.0149 | 0.1077 | 0.1077 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0073 | 0.0012 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0072 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.0486 | 0.1445 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0072 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.133 | 0.0887 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.0486 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0073 | 0.0073 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0076 | 0.0486 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1196 | 0.118 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0377 | 0.2934 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0076 | 0.0486 | 1 |
Brugia malayi | Inositol-1 | 0.0076 | 0.0486 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1077 | 0.106 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0073 | 0.0073 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.0486 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0073 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0073 | 0.0052 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0073 | 0.1112 |
Brugia malayi | hypothetical protein | 0.0163 | 0.1196 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.2919 | 0.2908 |
Onchocerca volvulus | 0.0163 | 0.1196 | 1 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0073 | 0.0073 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.133 | 0.0887 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0021 | 0.0204 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1247 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0377 | 0.2934 | 1 |
Schistosoma mansoni | protein kinase | 0.1247 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0073 | 0.0052 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0377 | 0.2934 | 0.2924 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0073 | 0.0012 |
Echinococcus granulosus | muscleblind protein | 0.0149 | 0.1077 | 0.0622 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1077 | 0.106 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0076 | 0.0486 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0073 | 0.1112 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0072 | 0.0072 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0076 | 0.0486 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0076 | 0.0486 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0073 | 0.1112 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1247 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0073 | 0.1112 |
Schistosoma mansoni | protein kinase | 0.1247 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.0486 | 0.1445 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0073 | 0.0052 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0073 | 0.0012 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0021 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0068 | 0.0421 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0149 | 0.1077 | 0.0622 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0073 | 0.147 |
Echinococcus multilocularis | geminin | 0.018 | 0.133 | 0.0887 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0072 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0076 | 0.0486 | 0.0466 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0068 | 0.0421 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1245 | 0.9985 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0073 | 0.147 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.