Detailed information for compound 715308

Basic information

Technical information
  • TDR Targets ID: 715308
  • Name: N-[2-[(4-bromophenyl)amino]-2-oxoethyl]-4-chl orobenzamide
  • MW: 367.625 | Formula: C15H12BrClN2O2
  • H donors: 2 H acceptors: 2 LogP: 3.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Br)CNC(=O)c1ccc(cc1)Cl
  • InChi: 1S/C15H12BrClN2O2/c16-11-3-7-13(8-4-11)19-14(20)9-18-15(21)10-1-5-12(17)6-2-10/h1-8H,9H2,(H,18,21)(H,19,20)
  • InChiKey: CURBKHBTBRXCOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(4-bromophenyl)amino]-2-oxo-ethyl]-4-chloro-benzamide
  • N-[2-[(4-bromophenyl)amino]-2-keto-ethyl]-4-chloro-benzamide
  • ZINC04833063

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0 0.5
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0339 0.3812 1
Schistosoma mansoni microtubule-associated protein tau 0.082 1 1
Leishmania major DNA polymerase eta, putative 0.0053 0.0134 1
Echinococcus multilocularis dna polymerase eta 0.0053 0.0134 0.0134
Onchocerca volvulus 0.0043 0 0.5
Toxoplasma gondii ABC1 family protein 0.0043 0 0.5
Schistosoma mansoni hypothetical protein 0.0098 0.0716 0.0716
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0134 1
Schistosoma mansoni apoptosis regulator bax 0.0098 0.0716 0.0716
Loa Loa (eye worm) apoptosis regulator protein 0.0098 0.0716 1
Trichomonas vaginalis esterase, putative 0.0043 0 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0273 0.2966 0.7781
Trypanosoma brucei DNA polymerase eta, putative 0.0053 0.0134 1
Schistosoma mansoni hypothetical protein 0.0098 0.0716 0.0716
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0098 0.0716 0.0716
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0 0.5
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0098 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0053 0.0134 0.1873
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0098 0.0716 1
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0339 0.3812 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0 0.5
Onchocerca volvulus 0.0043 0 0.5
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0098 0.0716 0.0716
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0339 0.3812 1
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0339 0.3812 0.5
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0098 0.0716 0.0716
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0098 0.0716 0.0716
Echinococcus granulosus dna polymerase eta 0.0053 0.0134 0.0134
Echinococcus multilocularis microtubule associated protein 2 0.082 1 1
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0339 0.3812 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0716 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0 0.5
Treponema pallidum hypothetical protein 0.0339 0.3812 0.5
Schistosoma mansoni hypothetical protein 0.0098 0.0716 0.0716
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0134 0.1873
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0 0.5
Schistosoma mansoni DNA polymerase eta 0.0053 0.0134 0.0134
Onchocerca volvulus 0.0043 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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