Detailed information for compound 717923

Basic information

Technical information
  • TDR Targets ID: 717923
  • Name: 2-chloro-4-fluoro-N-(3-morpholin-4-ylpropyl)b enzamide
  • MW: 300.756 | Formula: C14H18ClFN2O2
  • H donors: 1 H acceptors: 1 LogP: 1.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)Cl)C(=O)NCCCN1CCOCC1
  • InChi: 1S/C14H18ClFN2O2/c15-13-10-11(16)2-3-12(13)14(19)17-4-1-5-18-6-8-20-9-7-18/h2-3,10H,1,4-9H2,(H,17,19)
  • InChiKey: RMSGLYAOLNFNCY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-4-fluoro-N-(3-morpholinopropyl)benzamide
  • IVK/0011054

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major polypeptide deformylase-like protein, putative 0.0087 0.1949 0.1855
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0579 0.1064
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0361 0.0361
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0579 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0087 0.1949 0.1855
Loa Loa (eye worm) hypothetical protein 0.0197 0.4907 0.4907
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0229 0.5783 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0579 1
Echinococcus granulosus lamin dm0 0.0029 0.0361 0.0564
Toxoplasma gondii hypothetical protein 0.0229 0.5783 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0115 0.0115
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0229 0.5783 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0579 0.1064
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0361 0.0361
Schistosoma mansoni lamin 0.0029 0.0361 0.0564
Loa Loa (eye worm) hypothetical protein 0.0028 0.0347 0.0347
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0115 0.0115
Onchocerca volvulus Huntingtin homolog 0.0128 0.3049 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0579 0.1064
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0579 0.0579
Onchocerca volvulus Huntingtin homolog 0.0128 0.3049 1
Treponema pallidum polypeptide deformylase (def) 0.0229 0.5783 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0385 1 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0579 0.1064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0361 0.0361
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0579 1
Brugia malayi hypothetical protein 0.0128 0.3049 0.3049
Trypanosoma cruzi Peptide deformylase 2, putative 0.0087 0.1949 0.1855
Loa Loa (eye worm) hypothetical protein 0.0128 0.3049 0.3049
Echinococcus multilocularis lamin 0.0029 0.0361 0.0564
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0579 0.0469
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0579 0.0469
Loa Loa (eye worm) hypothetical protein 0.0128 0.3049 0.3049
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0579 0.0469
Plasmodium falciparum peptide deformylase 0.0229 0.5783 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0087 0.1949 0.1855
Schistosoma mansoni hypothetical protein 0.0181 0.4471 1
Chlamydia trachomatis peptide deformylase 0.0229 0.5783 0.5
Trypanosoma brucei Polypeptide deformylase 1 0.0087 0.1949 0.1855
Echinococcus multilocularis lamin dm0 0.0029 0.0361 0.0564
Echinococcus multilocularis geminin 0.0181 0.4471 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0361 0.0564
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0579 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0579 0.0469
Echinococcus multilocularis musashi 0.0029 0.0361 0.0564
Schistosoma mansoni intermediate filament proteins 0.0029 0.0361 0.0564
Loa Loa (eye worm) hypothetical protein 0.0385 1 1
Leishmania major C-8 sterol isomerase-like protein 0.0385 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0361 0.0361
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0229 0.5783 0.5
Schistosoma mansoni hypothetical protein 0.0181 0.4471 1
Mycobacterium ulcerans peptide deformylase 0.0229 0.5783 1
Brugia malayi intermediate filament protein 0.0029 0.0361 0.0361
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0087 0.1949 0.1855
Echinococcus granulosus geminin 0.0181 0.4471 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0579 0.1064
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0579 0.1064
Plasmodium vivax peptide deformylase, putative 0.0229 0.5783 1
Echinococcus granulosus lamin 0.0029 0.0361 0.0564
Loa Loa (eye worm) hypothetical protein 0.0037 0.0579 0.0579
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0579 0.1064
Schistosoma mansoni lamin 0.0029 0.0361 0.0564
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0579 0.1064
Trypanosoma brucei Peptide deformylase 2 0.0087 0.1949 0.1855
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0579 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0385 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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