Detailed information for compound 717923

Basic information

Technical information
  • TDR Targets ID: 717923
  • Name: 2-chloro-4-fluoro-N-(3-morpholin-4-ylpropyl)b enzamide
  • MW: 300.756 | Formula: C14H18ClFN2O2
  • H donors: 1 H acceptors: 1 LogP: 1.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)Cl)C(=O)NCCCN1CCOCC1
  • InChi: 1S/C14H18ClFN2O2/c15-13-10-11(16)2-3-12(13)14(19)17-4-1-5-18-6-8-20-9-7-18/h2-3,10H,1,4-9H2,(H,17,19)
  • InChiKey: RMSGLYAOLNFNCY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-4-fluoro-N-(3-morpholinopropyl)benzamide
  • IVK/0011054

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0028 0.0347 0.0347
Schistosoma mansoni hypothetical protein 0.0181 0.4471 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0087 0.1949 0.1855
Schistosoma mansoni lamin 0.0029 0.0361 0.0564
Schistosoma mansoni lamin 0.0029 0.0361 0.0564
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0579 0.1064
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0579 0.1064
Leishmania major C-8 sterol isomerase-like protein 0.0385 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0361 0.0361
Trypanosoma brucei Peptide deformylase 2 0.0087 0.1949 0.1855
Trypanosoma brucei C-8 sterol isomerase, putative 0.0385 1 1
Echinococcus multilocularis lamin 0.0029 0.0361 0.0564
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0229 0.5783 0.5
Loa Loa (eye worm) hypothetical protein 0.0385 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0115 0.0115
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0579 0.1064
Loa Loa (eye worm) hypothetical protein 0.0197 0.4907 0.4907
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0579 0.0469
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0579 0.1064
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0579 0.1064
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0579 0.0469
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0115 0.0115
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0579 0.1064
Loa Loa (eye worm) hypothetical protein 0.0128 0.3049 0.3049
Brugia malayi hypothetical protein 0.0128 0.3049 0.3049
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0229 0.5783 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0579 0.1064
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0361 0.0361
Plasmodium falciparum peptide deformylase 0.0229 0.5783 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0361 0.0361
Schistosoma mansoni hypothetical protein 0.0181 0.4471 1
Plasmodium vivax peptide deformylase, putative 0.0229 0.5783 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0579 1
Toxoplasma gondii hypothetical protein 0.0229 0.5783 1
Trypanosoma brucei Polypeptide deformylase 1 0.0087 0.1949 0.1855
Treponema pallidum polypeptide deformylase (def) 0.0229 0.5783 1
Echinococcus granulosus lamin dm0 0.0029 0.0361 0.0564
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0229 0.5783 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0361 0.0564
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0128 0.3049 0.3049
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0579 1
Brugia malayi intermediate filament protein 0.0029 0.0361 0.0361
Trypanosoma cruzi Peptide deformylase 2, putative 0.0087 0.1949 0.1855
Mycobacterium ulcerans peptide deformylase 0.0229 0.5783 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0579 1
Echinococcus granulosus geminin 0.0181 0.4471 1
Echinococcus granulosus lamin 0.0029 0.0361 0.0564
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0579 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0579 0.0469
Chlamydia trachomatis peptide deformylase 0.0229 0.5783 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0579 1
Onchocerca volvulus Huntingtin homolog 0.0128 0.3049 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0579 0.0579
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0579 0.0469
Schistosoma mansoni intermediate filament proteins 0.0029 0.0361 0.0564
Echinococcus multilocularis musashi 0.0029 0.0361 0.0564
Echinococcus multilocularis lamin dm0 0.0029 0.0361 0.0564
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0385 1 1
Onchocerca volvulus Huntingtin homolog 0.0128 0.3049 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0087 0.1949 0.1855
Trypanosoma cruzi Peptide deformylase 2, putative 0.0087 0.1949 0.1855
Echinococcus multilocularis geminin 0.0181 0.4471 1
Leishmania major polypeptide deformylase-like protein, putative 0.0087 0.1949 0.1855
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0579 0.1064

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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