TDR Targets

Basic information

Technical information

TDR Targets ID: 719630
Name: 1-(2-oxopropoxy)-7,8,9,10-tetrahydronaphtho[1 ,2-c]isochromen-6-one
MW: 322.355 | Formula: C20H18O4
H donors: 0 H acceptors: 2 LogP: 3.82 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)COc1cccc2c1ccc1c2oc(=O)c2c1CCCC2
InChi: 1S/C20H18O4/c1-12(21)11-23-18-8-4-7-15-14(18)9-10-16-13-5-2-3-6-17(13)20(22)24-19(15)16/h4,7-10H,2-3,5-6,11H2,1H3
InChiKey: VDIGXAOLPMZXDZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-acetonyloxy-7,8,9,10-tetrahydronaphtho[1,2-c]isochromen-6-one
ST5327077
ZINC01050488

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0129	0.0428
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0161	0.1836	0.5971
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	0.3511	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0129	0.0685
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0552	0.1787
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0226	0.1215
Onchocerca volvulus		0.0093	0.0993	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0129	0.0358
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0003	0.0121
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0583	0.0568
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0282	1
Schistosoma mansoni	cpg binding protein	0.0058	0.0552	0.0537
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0282	0.0793
Echinococcus granulosus	cpg binding protein	0.0061	0.0593	0.0578
Trypanosoma brucei	glucosidase, putative	0.0036	0.0282	0.0793
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0129	0.5
Schistosoma mansoni	hypothetical protein	0.0031	0.0226	0.0211
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0226	0.0211
Schistosoma mansoni	cpg binding protein	0.0061	0.0593	0.0578
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0282	1
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0059	0.0181
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0003	0.0121
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0013	0.0003	0.0121
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0129	0.0358
Schistosoma mansoni	alpha glucosidase	0.0036	0.0282	0.0266
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0468	0.1324
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0282	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0161	0.1836	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0003	0.0121
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0583	0.1079
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0129	0.0685
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0129	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1064	0.3455
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.1064	0.5787
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0129	0.4515
Schistosoma mansoni	alpha-glucosidase	0.0139	0.1557	0.1544
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0129	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0261	0.3072	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0129	0.0428
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0059	0.0044
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0226	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0261	0.3072	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0226	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0226	0.0726
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0355	0.1002
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0129	0.0494
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0282	0.0266
Toxoplasma gondii	hypothetical protein	0.0048	0.0431	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0129	0.0409
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0129	0.0428
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0261	0.3072	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0056	0.017
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0056	0.017
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0129	0.0494
Schistosoma mansoni	cpg binding protein	0.0061	0.0593	0.0578
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0056	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0226	0.0211
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0552	0.2993
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0282	0.1518
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0122	0.1352	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0129	0.0409
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0226	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0056	0.017
Loa Loa (eye worm)	hypothetical protein	0.0261	0.3072	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0583	0.0568
Onchocerca volvulus		0.0023	0.0129	0.1268
Onchocerca volvulus		0.0058	0.0552	0.5539
Schistosoma mansoni	alpha-glucosidase	0.0139	0.1557	0.1544
Schistosoma mansoni	hypothetical protein	0.0031	0.0226	0.0211
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0056	0.0069
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0129	0.0428
Mycobacterium ulcerans	hypothetical protein	0.0156	0.1773	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0226	0.0211
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0056	0.0289
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0282	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0583	0.307
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0003	0.0121
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0109	0.119	0.3256
Toxoplasma gondii	hypothetical protein	0.0261	0.3072	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.1836	0.1823
Schistosoma mansoni	hypothetical protein	0.0068	0.0676	0.0661
Schistosoma mansoni	microtubule-associated protein tau	0.0691	0.8409	0.8406
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0583	0.307
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0226	0.0211
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0282	0.0793
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0129	0.4515
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0355	0.1002
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0226	0.1215
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.1064	0.5787
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0676	0.3671
Echinococcus granulosus	GPCR family 2	0.0031	0.0226	0.0211
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.1576	0.4485
Echinococcus granulosus	microtubule associated protein 2	0.0691	0.8409	0.8406
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0583	0.1652
Echinococcus multilocularis	dnaJ subfamily B	0.0819	1	1
Leishmania major	mitochondrial DNA polymerase beta	0.0296	0.3511	1
Echinococcus multilocularis	microtubule associated protein 2	0.0691	0.8409	0.8406
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0282	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0129	0.0409
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0003	0.0121
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0129	0.4515
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0296	0.3511	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0129	0.0428
Echinococcus granulosus	lysosomal alpha glucosidase	0.0161	0.1836	0.1823
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0282	1
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0282	0.0793
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0056	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0056	0.017
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0129	0.0428
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0059	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0676	0.2192
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0129	0.5
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0129	0.0685
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.1064	0.3455
Schistosoma mansoni	hypothetical protein	0.0031	0.0226	0.0211
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0583	0.307
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0129	0.0428
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0282	0.0266
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0282	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.1576	0.4485
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0282	0.0906
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0583	0.0568
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.1836	0.1823
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0583	0.0568
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0355	0.1002
Schistosoma mansoni	hypothetical protein	0.0819	1	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0282	1
Echinococcus multilocularis	cpg binding protein	0.0061	0.0593	0.0578
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0156	0.1773	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.1576	0.4485
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0583	0.3117
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0056	0.017
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0013	0.0003	0.0121
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	0.3511	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0013	0.0003	0.0121
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0056	0.5
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0282	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0282	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0282	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0355	0.1002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 719630