TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 500.443 | Formula: C19H29N6O8P
H donors: 8 H acceptors: 7 LogP: -5.77 Rotable bonds: 13
Rule of 5 violations (Lipinski): 3
SMILES: NC(=O)CC(C(=O)N)NC(=O)C1(CCCC1)NC(=O)C(Cc1ccc(c(c1)N)OP(=O)(O)O)N
InChi: 1S/C19H29N6O8P/c20-11-7-10(3-4-14(11)33-34(30,31)32)8-12(21)17(28)25-19(5-1-2-6-19)18(29)24-13(16(23)27)9-15(22)26/h3-4,7,12-13H,1-2,5-6,8-9,20-21H2,(H2,22,26)(H2,23,27)(H,24,29)(H,25,28)(H2,30,31,32)
InChiKey: JSBGEXFUYQLMBR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	transfer RNA-Gly	0.0037	0.0442	0.2066
Echinococcus multilocularis	calcium activated potassium channel	0.0037	0.0442	0.2066
Schistosoma mansoni	tyrosine kinase	0.0012	0.0068	0.032
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0037	0.0442	0.2066
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0037	0.0442	0.2066
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0037	0.0442	0.0521
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0442	0.5
Echinococcus granulosus	potassium large conductance calcium activated	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0037	0.0442	0.2066
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Loa Loa (eye worm)	voltage-gated calcium channel	0.0037	0.0442	0.1804
Trypanosoma brucei	telomerase reverse transcriptase	0.0187	0.2652	1
Schistosoma mansoni	voltage-dependent calcium channel	0.0037	0.0442	0.2066
Brugia malayi	Transient-receptor-potential like protein	0.0037	0.0442	0.0521
Echinococcus multilocularis	transient receptor potential cation channel	0.0039	0.0461	0.2155
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0037	0.0442	0.0521
Brugia malayi	olfactory channel protein osm-9	0.0039	0.0461	0.0547
Echinococcus multilocularis	ryanodine receptor 44f	0.0037	0.0442	0.2066
Schistosoma mansoni	transient receptor potential channel	0.0037	0.0442	0.2066
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0037	0.0442	0.0521
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0037	0.0442	0.2066
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0012	0.0068	0.032
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0037	0.0442	0.2066
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0152	0.2138	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0012	0.0068	0.032
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Schistosoma mansoni	vesicular amine transporter	0.0037	0.0442	0.2066
Echinococcus multilocularis	conserved hypothetical protein	0.0037	0.0442	0.2066
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0442	0.2066
Echinococcus multilocularis	voltage dependent calcium channel	0.0037	0.0442	0.2066
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0037	0.0442	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Schistosoma mansoni	60S ribosomal protein L21	0.0037	0.0442	0.2066
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0152	0.2138	1
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	potassium large conductance calcium activated	0.0037	0.0442	0.2066
Echinococcus multilocularis	sodium channel protein	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	NCK adaptor protein	0.0012	0.0068	0.032
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0037	0.0442	0.2066
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0037	0.0442	0.2066
Echinococcus granulosus	hypothetical protein	0.0037	0.0442	0.2066
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0012	0.0068	0.032
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0012	0.0068	0.032
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Echinococcus granulosus	voltage dependent calcium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0012	0.0068	0.032
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0037	0.0442	0.0521
Brugia malayi	Sex muscle abnormal protein 5	0.0152	0.2138	0.2886
Echinococcus multilocularis	potassium voltage gated channel protein	0.0037	0.0442	0.2066
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0461	0.1896
Echinococcus multilocularis	voltage gated potassium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	potassium voltage gated channel protein	0.0037	0.0442	0.2066
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0037	0.0442	0.2066
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0037	0.0442	0.2066
Echinococcus granulosus	sodium leak channel non selective protein	0.0037	0.0442	0.2066
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0442	0.0521
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0037	0.0442	0.0521
Echinococcus granulosus	transient receptor potential gamma protein	0.0037	0.0442	0.2066
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0037	0.0442	0.0521
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0442	0.2066
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0442	0.2066
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0037	0.0442	0.2066
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0187	0.2652	1
Echinococcus multilocularis	shaker cognate	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Echinococcus granulosus	hyperpolarization activated cyclic	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	transient receptor potential cation channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0037	0.0442	0.2066
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0442	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0012	0.0068	0.032
Echinococcus multilocularis	transient receptor potential cation channel	0.0037	0.0442	0.2066
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	sodium channel protein	0.0037	0.0442	0.2066
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Schistosoma mansoni	nck2/grb4	0.0012	0.0068	0.032
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0037	0.0442	0.2066
Echinococcus granulosus	voltage gated potassium channel	0.0037	0.0442	0.2066
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0037	0.0442	0.1804
Echinococcus multilocularis	short transient receptor potential channel 6	0.0039	0.0461	0.2155
Schistosoma mansoni	transient receptor potential channel 4	0.0037	0.0442	0.2066
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0012	0.0068	0.032
Echinococcus granulosus	transient receptor potential cation channel	0.0037	0.0442	0.2066
Schistosoma mansoni	ryanodine receptor related	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Brugia malayi	voltage-dependent calcium channel	0.0037	0.0442	0.0521
Echinococcus multilocularis	two pore calcium channel protein 2	0.0037	0.0442	0.2066
Schistosoma mansoni	tyrosine kinase	0.0012	0.0068	0.032
Schistosoma mansoni	growth factor receptor-bound protein	0.0152	0.2138	1
Echinococcus granulosus	voltage dependent calcium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0012	0.0068	0.032
Loa Loa (eye worm)	voltage-gated potassium channel	0.0037	0.0442	0.1804
Echinococcus granulosus	shaker cognate	0.0037	0.0442	0.2066
Echinococcus multilocularis	NCK adaptor protein	0.0012	0.0068	0.032
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0037	0.0442	0.0521
Giardia lamblia	Telomerase catalytic subunit	0.0187	0.2652	0.5
Schistosoma mansoni	voltage-gated cation channel	0.0037	0.0442	0.2066
Leishmania major	telomerase reverse transcriptase, putative	0.0187	0.2652	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0037	0.0442	0.0521
Echinococcus granulosus	transient receptor potential cation channel	0.0037	0.0442	0.2066
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0037	0.0442	0.2066
Schistosoma mansoni	hypothetical protein	0.0037	0.0442	0.2066
Brugia malayi	ion channel NompC	0.0037	0.0442	0.0521
Echinococcus multilocularis	c src tyrosine kinase	0.0012	0.0068	0.032
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0187	0.2652	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0012	0.0068	0.032
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0037	0.0442	0.2066
Schistosoma mansoni	tyrosine kinase	0.0012	0.0068	0.032
Schistosoma mansoni	transient receptor potential channel	0.0037	0.0442	0.2066
Echinococcus granulosus	short transient receptor potential channel 6	0.0037	0.0442	0.2066
Echinococcus granulosus	hyperpolarization activated cyclic	0.0037	0.0442	0.2066
Echinococcus multilocularis	transient receptor potential cation channel	0.0039	0.0461	0.2155
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0037	0.0442	0.0521
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0012	0.0068	0.032
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Echinococcus multilocularis	voltage gated potassium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	transient receptor potential cation channel	0.0037	0.0442	0.2066
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0012	0.0068	0.032
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0037	0.0442	0.2066
Echinococcus multilocularis	sodium leak channel non selective protein	0.0037	0.0442	0.2066
Echinococcus granulosus	growth factor receptor bound protein 2	0.0152	0.2138	1
Echinococcus multilocularis	transient receptor potential gamma protein	0.0037	0.0442	0.2066
Loa Loa (eye worm)	ryanodine receptor	0.0037	0.0442	0.1804
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0037	0.0442	0.1804
Brugia malayi	hypothetical protein	0.0037	0.0442	0.0521
Echinococcus multilocularis	potassium voltage gated channel protein	0.0037	0.0442	0.2066
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0037	0.0442	0.0521
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0037	0.0442	0.0521
Echinococcus granulosus	potassium voltage gated channel protein	0.0037	0.0442	0.2066
Echinococcus granulosus	calcium activated potassium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0012	0.0068	0.032
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0012	0.0068	0.032
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0037	0.0442	0.2066
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0012	0.0068	0.032
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0037	0.0442	0.2066
Echinococcus granulosus	transient receptor potential cation channel	0.0039	0.0461	0.2155
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Echinococcus granulosus	two pore calcium channel protein 1	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Echinococcus granulosus	potassium voltage gated channel protein	0.0037	0.0442	0.2066
Schistosoma mansoni	two-pore calcium channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	transient receptor potential cation channel	0.0037	0.0442	0.2066
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0037	0.0442	0.2066
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0037	0.0442	0.2066
Brugia malayi	cation channel family protein	0.0037	0.0442	0.0521
Echinococcus multilocularis	potassium voltage gated channel protein	0.0037	0.0442	0.2066
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0037	0.0442	0.2066
Echinococcus multilocularis	two pore calcium channel protein 1	0.0037	0.0442	0.2066
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0442	0.1804
Schistosoma mansoni	tyrosine kinase	0.0012	0.0068	0.032
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Loa Loa (eye worm)	voltage-gated potassium channel	0.0037	0.0442	0.1804
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0037	0.0442	0.2066
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0012	0.0068	0.032
Schistosoma mansoni	adapter molecule crk	0.0012	0.0068	0.032
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0037	0.0442	0.2066
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0037	0.0442	0.2066
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0012	0.0068	0.032
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0012	0.0068	0.032
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0012	0.0068	0.032
Echinococcus granulosus	ryanodine receptor 44f	0.0037	0.0442	0.2066
Echinococcus multilocularis	voltage dependent calcium channel	0.0037	0.0442	0.2066
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0037	0.0442	0.2066
Loa Loa (eye worm)	calcium channel	0.0037	0.0442	0.1804
Echinococcus granulosus	TRP transient receptor potential channel	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0037	0.0442	0.0521
Brugia malayi	cation channel family protein	0.0037	0.0442	0.0521
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0037	0.0442	0.2066
Loa Loa (eye worm)	ion channel NompC	0.0037	0.0442	0.1804
Echinococcus granulosus	two pore calcium channel protein 2	0.0037	0.0442	0.2066
Echinococcus multilocularis	short transient receptor potential channel 6	0.0037	0.0442	0.2066
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0012	0.0068	0.032
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0037	0.0442	0.2066
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0037	0.0442	0.0521
Echinococcus granulosus	potassium voltage gated channel protein	0.0037	0.0442	0.2066
Schistosoma mansoni	transient receptor potential channel	0.0039	0.0461	0.2155
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Echinococcus multilocularis	potassium voltage gated channel protein	0.0037	0.0442	0.2066
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0037	0.0442	0.1804
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus granulosus	voltage gated potassium channel	0.0037	0.0442	0.2066
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Schistosoma mansoni	calcium-activated potassium channel	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0442	0.2066
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0037	0.0442	0.2066
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0442	0.1804
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0012	0.0068	0.032
Echinococcus granulosus	short transient receptor potential channel 6	0.0039	0.0461	0.2155
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0037	0.0442	0.2066
Schistosoma mansoni	voltage-gated ion channel	0.0037	0.0442	0.2066
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0187	0.2652	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0442	0.2066
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0037	0.0442	0.2066
Toxoplasma gondii	RNA-directed DNA polymerase	0.0187	0.2652	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0012	0.0068	0.032
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0012	0.0068	0.032
Brugia malayi	Telomerase reverse transcriptase	0.0497	0.7239	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0037	0.0442	0.2066
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0037	0.0442	0.2066
Echinococcus granulosus	transient receptor potential cation channel	0.0037	0.0442	0.2066
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0037	0.0442	0.2066
Echinococcus multilocularis	transient receptor potential cation channel	0.0037	0.0442	0.2066
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0037	0.0442	0.2066
Plasmodium falciparum	telomerase reverse transcriptase	0.0187	0.2652	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0012	0.0068	0.032
Schistosoma mansoni	growth factor receptor-bound protein	0.0152	0.2138	1
Echinococcus granulosus	transient receptor potential cation channel	0.0037	0.0442	0.2066
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0037	0.0442	0.0521
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0037	0.0442	0.2066
Echinococcus granulosus	potassium voltage gated channel protein	0.0037	0.0442	0.2066

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 23 nM	Inhibition of binding to Grb2 SH2 domain	ChEMBL.	9599224

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 173512

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 72096