pI: 9.2599 |
Length (AA): 1912 |
MW (Da): 219936 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 16
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
769 | 1014 | 5ek0 (A) | 1532 | 1721 | 29.00 | 0.0000000042 | 0.16 | -0.142339 | 2.3 |
1115 | 1293 | 4dxw (A) | 52 | 221 | 31.00 | 0.00000033 | 0.09 | -0.0793808 | 1.85 |
1266 | 1295 | 5jr0 (A) | 2 | 31 | 37.00 | 0.53 | 0.02 | 0.0156904 | 3.65 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131009)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_44965 | Voltage-gated calcium channel, alpha subunit |
Candida albicans | CaO19.3298 | likely ion transport protein similar to S. cerevisiae CCH1 (YGR217W) calcium channel |
Candida albicans | CaO19.10808 | likely ion transport protein similar to S. cerevisiae CCH1 (YGR217W) calcium channel |
Caenorhabditis elegans | CELE_F17C8.6 | Protein F17C8.6 |
Caenorhabditis elegans | CELE_C27F2.2 | Protein NCA-2, isoform A |
Caenorhabditis elegans | CELE_C11D2.6 | Protein UNC-77, isoform D |
Drosophila melanogaster | Dmel_CG1517 | narrow abdomen |
Echinococcus granulosus | EgrG_001034100 | sodium leak channel non selective protein |
Echinococcus multilocularis | EmuJ_001034100 | sodium leak channel non selective protein |
Homo sapiens | ENSG00000102452 | sodium leak channel, non-selective |
Loa Loa (eye worm) | LOAG_04821 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07033 | voltage-gated calcium channel |
Mus musculus | ENSMUSG00000000197 | sodium leak channel, non-selective |
Saccharomyces cerevisiae | YGR217W | Cch1p |
Schistosoma japonicum | Sjp_0122160 | Sodium leak channel non-selective protein, putative |
Schistosoma japonicum | Sjp_0114450 | expressed protein |
Schistosoma japonicum | Sjp_0032270 | Sodium leak channel non-selective protein, putative |
Schistosoma japonicum | Sjp_0311080 | expressed protein |
Schistosoma japonicum | Sjp_0115560 | Sodium leak channel non-selective protein, putative |
Schistosoma mansoni | Smp_141780 | voltage-dependent calcium channel |
Schmidtea mediterranea | mk4.013405.00 | |
Schmidtea mediterranea | mk4.026133.00 | Sodium leak channel non-selective protein |
Schmidtea mediterranea | mk4.006686.01 | Sodium leak channel non-selective protein |
Schmidtea mediterranea | mk4.013405.01 | |
Schmidtea mediterranea | mk4.006686.05 | |
Schmidtea mediterranea | mk4.024311.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.