Detailed information for compound 721589

Basic information

Technical information
  • TDR Targets ID: 721589
  • Name: 2-(4-methoxyphenyl)-N-[[3-(4-methylphenyl)-1, 2,4-oxadiazol-5-yl]methyl]acetamide
  • MW: 337.372 | Formula: C19H19N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(=O)NCc1onc(n1)c1ccc(cc1)C
  • InChi: 1S/C19H19N3O3/c1-13-3-7-15(8-4-13)19-21-18(25-22-19)12-20-17(23)11-14-5-9-16(24-2)10-6-14/h3-10H,11-12H2,1-2H3,(H,20,23)
  • InChiKey: MPIZNIGZSUHRGP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenyl)-N-[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]ethanamide
  • ZINC04837885
  • STK239455

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0058 0.061 0.1229
Onchocerca volvulus Peroxidase homolog 0.0164 0.4964 1
Brugia malayi Animal haem peroxidase family protein 0.0164 0.4964 0.4964
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Echinococcus granulosus peroxidasin 0.0164 0.4964 0.4964
Loa Loa (eye worm) animal heme peroxidase 0.0164 0.4964 0.4964
Brugia malayi hypothetical protein 0.0164 0.4964 0.4964
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0691 0.0691
Toxoplasma gondii ABC1 family protein 0.0043 0 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0 0.5
Leishmania major hypothetical protein, conserved 0.0043 0 0.5
Trichomonas vaginalis esterase, putative 0.0043 0 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0691 0.0691
Brugia malayi Animal haem peroxidase family protein 0.0164 0.4964 0.4964
Onchocerca volvulus 0.0164 0.4964 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Onchocerca volvulus 0.0164 0.4964 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0043 0 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0164 0.4964 0.4964
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Mycobacterium leprae Probable lipase LipE 0.0043 0 0.5
Brugia malayi Animal haem peroxidase family protein 0.0164 0.4964 0.4964
Onchocerca volvulus Peroxidasin homolog 0.0164 0.4964 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Onchocerca volvulus Dual oxidase homolog 0.0164 0.4964 1
Echinococcus multilocularis peroxidasin 0.0164 0.4964 0.4964
Onchocerca volvulus 0.0058 0.061 0.1229
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0 0.5
Mycobacterium ulcerans beta-lactamase 0.0043 0 0.5
Brugia malayi Peroxidasin 0.0164 0.4964 0.4964
Loa Loa (eye worm) hypothetical protein 0.0286 1 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Onchocerca volvulus Chorion peroxidase homolog 0.0164 0.4964 1
Onchocerca volvulus Peroxidase homolog 0.0164 0.4964 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0164 0.4964 0.4964
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0 0.5
Schistosoma mansoni survival motor neuron protein 0.0058 0.061 0.1229
Mycobacterium ulcerans lipase LipD 0.0043 0 0.5
Onchocerca volvulus Peroxidasin homolog 0.0164 0.4964 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0691 0.0691
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Loa Loa (eye worm) animal heme peroxidase 0.0164 0.4964 0.4964
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0691 0.0691
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.9679 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0 0.5
Echinococcus granulosus survival motor neuron protein 1 0.0286 1 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0 0.5
Schistosoma mansoni peroxidasin 0.0164 0.4964 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Echinococcus multilocularis survival motor neuron protein 1 0.0286 1 1
Schistosoma mansoni peroxidasin 0.0164 0.4964 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Loa Loa (eye worm) animal heme peroxidase 0.0164 0.4964 0.4964
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Brugia malayi Animal haem peroxidase family protein 0.0164 0.4964 0.4964
Loa Loa (eye worm) hypothetical protein 0.0164 0.4964 0.4964
Onchocerca volvulus 0.0164 0.4964 1
Brugia malayi Animal haem peroxidase family protein 0.0164 0.4964 0.4964
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0 0.5
Brugia malayi Blistered cuticle protein 3 0.0164 0.4964 0.4964

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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